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C. Carillo-Carrión, B. Simonet, M. Valcárcel, B. Lendl:
"Determination of pesticides by capillary chromatography and surface enhanced Raman scattering using a noval silver-quantum dots nanocomposite";
Journal of Chromatography A, A (2012), 1225; 55 - 61.

In this work the at-line capillary-liquid chromatography-(microdispenser)-surface-enhanced Raman
spectroscopy coupling was investigated and applied to the determination of pesticides. The use of
a microdispenser combined with the use of a precise and reproducible surface enhanced Raman
spectroscopy (SERS) substrate yielded a chromatographic detection system with excellent analytical
properties. The microdispenser was coupled to a moving CaF2 hot (80 ◦C) plate using a flow-through
microdispenser interface to collect the microdrops. Ag-QD nanocomposites, which are highly reproducible
thanks to their sponge-shaped structure, were used as substrate with which to measure the SERS
spectra in each spot of the plate. The limits of detection ranged from 0.2 to 0.5 ng of pesticide injected
(chlortoluron, atrazine, diuron and terbuthylazine) and the precision ranged between 10.2 and 12.5%

http://dx.doi.org/10.1016/j.chroma.2011.12.002