[Back]

E. Semenova, V. Presniakova, V. Kozlovskaya, N. Markelova, A.N. Gusev, W. Linert, A. Kurakov, A. Shpichka:
"The In Vitro Cytotoxicity of Eremothеcium oil and its Components-Aromatic and Acyclic Monoterpene Alcohols";
International Journal of Molecular Sciences, 23 (2022), 3364 - 3374.

The microscopic fungi Eremothecium ashbyi and E. gossypii are known for their ability to synthetize essential oil, which has a composition similar to that of rose oil. The development of Eremothecium oil technology enables the production of rose-scented products, which are demanded by pharmaceutical, food, and perfumery industries. This study focuses on assessing the in vitro cytotoxicity of Eremothecium oil, in comparison with that of rose oil, using a combination of methods and two cell types (3T3 mouse fibroblast cell line and bone-marrow-derived mesenchymal stromal cells (BM-MSCs)). The Eremothecium oil samples possessed cytotoxic effects that varied among strains and batches. The revealed cytotoxicity level may be used to tailor the qualitative and quantitative composition of Eremothecium oil to achieve a particular quality in its end products. These results require further analysis using other cell types and assays based on measuring other cell functions.

terpene; essential oil; Eremothecium gossypii; Eremothecium ashbyi; cytotoxicity; rose oil; 2- phenylethanol; geraniol; citral; citronellol; nerol; linalool; Rosa damascena; Rosa gallica

http://dx.doi.org/10.3390/ijms23063364