Publication list for
Julian Kager
as author or essentially involved person
57 records (2015 - 2022)
Publications in Scientific Journals
D. Ehgartner, T. Hartmann, S. Heinzl, M. Frank, L. Veiter, J. Kager, C. Herwig, J. Fricke:
"Controlling the specific growth rate via biomass trend regulation in filamentous fungi bioprocesses";
Chemical Engineering Science,
172
(2017),
32
- 41.
O. Goldbeck, D. Desef, K. Ovchinnikov, F. Perez-Garcia, J. Christmann, P. Sinner, P. Crauwels, J. Kager, C. Herwig et al.:
"Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum";
Metabolic Engineering,
68
(2021),
34
- 45.
M. Jouned, J. Kager, C. Herwig, T. Barz:
"Event driven modeling for the accurate identification of metabolic switches in fed-batch culture of S. cerevisiae";
Biochemical Engineering Journal,
180
(2022).
J. Kager, J. Bartlehner, C. Herwig, S. Jakubek:
"Direct control of recombinant protein production rates in E. coli fed-batch processes by nonlinear feedback linearization";
Chemical Engineering Research and Design,
182
(2022),
290
- 304.
J. Kager, C. Herwig:
"Monte Carlo-Based Error Propagation for a More Reliable Regression Analysis across Specific Rates in Bioprocesses";
Bioengineering,
8
(2021),
160;
17 pages.
J. Kager, C. Herwig:
"Simulieren, Observieren, Kontrollieren - Vorhersage des Wachstumsverhaltens von Penicillium chrysogenum";
GIT Labor-Fachzeitschrift,
62
(2018),
8;
32
- 34.
J. Kager, C. Herwig, I. Stelzer:
"State estimation for a penicillin fed-batch process combining particle filtering methods with online and time delayed offline measurements";
Chemical Engineering Science,
177
(2018),
234
- 244.
J. Kager, A. Tuveri, S. Ulonska, P. Kroll, C. Herwig:
"Experimental verification and comparison of model predictive, PID and model inversion control in a Penicillium chrysogenum fed-batch process";
Process Biochemistry,
90
(2020),
1
- 11.
J. Kopp, C. Slouka, D. Strohmer, J. Kager, O. Spadiut, C. Herwig:
"Inclusion Body Bead Size in E. coli Controlled by Physiological Feeding";
Microorganisms,
6
(2018),
13 pages.
J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of Glycerol as Carbon Source onto Specific Sugar and Inducer Uptake Rates and Inclusion Body Productivity in E. coli BL21(DE3)";
Bioengineering,
5
(2018),
1;
15 pages.
P. Kroll, A. Hofer, S. Ulonska, J. Kager, C. Herwig:
"Model-Based Methods in the Biopharmaceutical Process Lifecycle";
Pharmaceutical Research,
34
(2017),
12;
2596
- 2613.
J. Pauk, J. Raju Palanisamy, J. Kager, K. Koczka, G. Berghammer, C. Herwig, L. Veiter:
"Advances in monitoring and control of refolding kinetics combining PAT and modeling";
Applied Microbiology and Biotechnology,
105
(2021),
2243
- 2260.
W. Reichelt, P. Thurrold, M. Brillmann, J. Kager, J. Fricke, C. Herwig:
"Generic biomass estimation methods targeting physiologic process control in induced bacterial cultures";
Engineering in Life Sciences,
16
(2016),
8;
720
- 730.
P. Sinner, J. Kager, S. Daume, C. Herwig:
"Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste";
IFAC PapersOnLine,
52
(2019),
26;
181
- 186.
P. Sinner, M. Stiegler, O. Goldbeck, G. Seibold, C. Herwig, J. Kager:
"Online estimation of changing metabolic capacities in continuous Corynebacterium glutamicum cultivations growing on a complex sugar mixture";
Biotechnology and Bioengineering,
119
(2022),
575
- 590.
P. Sinner, M. Stiegler, C. Herwig, J. Kager:
"Noninvasive online monitoring of Corynebacterium glutamicum fed-batch bioprocesses subject to spent sulfite liquor raw material uncertainty";
Bioresource Technology,
321
(2021).
C. Slouka, J. Kopp, D. Strohmer, J. Kager, O. Spadiut, C. Herwig:
"Monitoring and control strategies for inclusion body production in E. coli based on glycerol consumption";
Journal of Biotechnology,
296
(2019),
75
- 82.
S. Ulonska, D. Waldschitz, J. Kager, C. Herwig:
"Model predictive control in comparison to elemental balance control in an E. coli fed-batch";
Chemical Engineering Science,
191
(2018),
459
- 467.
L. Veiter, J. Kager, C. Herwig:
"Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed‑batch cultivations through morphological and physiological control";
Microbial Cell Factories,
19
(2020),
14 pages.
D. Zalai, J. Kopp, B. Kozma, M. Küchler, C. Herwig, J. Kager:
"Microbial technologies for biotherapeutics production: Key tools for advanced biopharmaceutical process development and control";
Drug Discovery Today: Technologies,
38
(2020),
9
- 24.
R. Zimmerleiter, J. Kager, R. Nikzad-Langerodi, V. Berezhinskiy, F. Westad, C. Herwig, M. Brandstetter:
"Probeless non-invasive near-infrared spectroscopic bioprocess monitoring using microspectrometer technology";
Analytical and Bioanalytical Chemistry,
412
(2020),
2103
- 2109.
Contributions to Books
T. Barz, J. Kager, C. Herwig, P. Neubauer, M. Cruz Bournazou, F. Galvanin:
"Characterization of reactions and growth in automated continuous flow and bioreactor platforms-From linear DoE to model-based approaches";
in: "Simulation and Optimization in Process Engineering",
M. Bortz, N. Asprion (ed.);
Elsevier Inc.,
Amsterdam, NL,
2022,
ISBN: 978-0-323-85043-8,
273
- 319.
S. Daume, J. Kager, C. Herwig:
"Time Resolved Sensitivity & Identifiability Analysis for Directed Parametrization of Highly Dynamic Models";
in: "Computer Aided Chemical Engineering, 29th European Symposium on Computer Aided Process Engineering",
46;
Elsevier,
2019,
ISBN: 978-0-12-818634-3,
1111
- 1116.
S. Daume, S. Kofler, J. Kager, P. Kroll, C. Herwig:
"Generic Workflow for the Setup of Mechanistic Process Models";
in: "Animal Cell Biotechnology",
Springer Science + Business Media,
2020,
ISBN: 978-1-0716-0190-7,
189
- 211.
J. Kager, V. Berezhinskiy, R. Zimmerleitner, M. Brandstetter, C. Herwig:
"Extension of a Particle Filter for Bioprocess State Estimation using Invasive and Non-Invasive IR Measurements";
in: "Computer Aided Chemical Engineering, 29th European Symposium on Computer Aided Process Engineering",
46;
Elsevier,
2019,
ISBN: 978-0-12-818634-3,
1417
- 1422.
P. Sinner, S. Daume, C. Herwig, J. Kager:
"Usage of Digital Twins Along a Typical Process Development Cycle";
in: "Digital Twins - Tools and Concepts for Smart Biomanufacturing",
C. Herwig, R. Pörtner, J. Möller (ed.);
Springer International Publishing,
2021,
ISBN: 978-3-030-71659-2.
P. Sinner, C. Herwig, J. Kager:
"Time Scale Analysis and Optimization of a Continuous Microbial Bioprocess";
in: "Computer Aided Chemical Engineering, 30th European Symposium on Computer Aided Process Engineering",
48;
S. Pierucci, F. Manenti, G. Bozzano, D. Manca (ed.);
Elsevier B.V.,
2020,
ISBN: 978-0-1282-3377-1,
1603
- 1608.
I. Stelzer, J. Kager, C. Herwig:
"Comparison of Particle Filter and Extended Kalman Filter Algorithms for Monitoring of Bioprocesses";
in: "Proceedings of the 27th European Symposium on Computer Aided Process Engineering - ESCAPE 27",
40;
A. Espuña, M. Graells, L. Puigjaner (ed.);
Elsevier B.V.,
2017,
ISBN: 978-0-444-63965-3,
1483
- 1488.
S. Ulonska, J. Kager, C. Herwig:
"Automatic controller failure detection with application in model based control of an E. coli fed-batch";
in: "Computer-Aided Chemical Engineering, Vol. 43 - 28th European Symposium on Computer Aided Process Engineering Part A",
A. Friedl, J. Klemes, S. Radl, P. Varbanov, T. Wallek (ed.);
Elsevier B.V.,
2018,
ISBN: 978-0-444-64237-0,
1673
- 1678.
Talks and Poster Presentations (with Proceedings-Entry)
T. Hardiman, M. Hofinger, P. Ettinger, G. Kornfeld, M. Weiner, P. Wechselberger, J. Buchholz, W. Riethorst, W. Skibar, J. Kager, I. Stelzer, A. Golabgir, D. Ehgartner, C. Herwig:
"Implementierung einer Softsenser-basierten Regelung eines großtechnischen Fermentationsprozesses";
Talk: 13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion,
Esslingen, Deutschland;
11-21-2017
- 11-22-2017; in: "Programm",
(2017),
50.
J. Kager:
"The deployment of mechanistic models in biotechnological production processes for advanced monitoring and control";
Talk: Corso di laurea in Ingegneria Chimica,
Cagliari, Italien (invited);
09-27-2018; in: "http://people.unica.it/ingegneriachimica/2018/09/26/avviso-seminario-julian-kager/",
(2018),
1 pages.
J. Kager, C. Herwig, V. Berezhinskiy:
"State estimation and control of bioprocesses based on mechanistic models";
Talk: IFPAC 2019 - 33rd International Forum and Exhibition on Process Analytical Chemistry (IFPAC) Annual Meeting,
Washington D.C., USA;
03-03-2019
- 03-06-2019; in: "Abstracts",
(2019),
1 pages.
J. Kager, S. Ulonska, F. Pollesböck, C. Herwig:
"Engineerīs Playground: Interfacing Students and Bioreactors for Teaching and Research";
Talk: VSS 2018 - Vienna Young Scientists Symposium,
Wien;
06-07-2018
- 06-08-2018; in: "VSS 2018",
Book-of-Abstracts.com,
(2018),
ISBN: 978-3-9504017-8-3;
64
- 65.
J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of glycerol as carbon source onto specific sugar and inducer uptake rates and inclusion body productivity in E. coli BL21 (DE3)";
Poster: 5th BioProScale Symposium,
Berlin, Deutschland;
03-20-2018
- 03-22-2018; in: "Abstract Booklet",
(2018),
48.
J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of glycerol as carbon source onto specific sugar and inducer uptake rates and inclusion body productivity in E. coli BL21(DE3)";
Talk: ESBES 2018 - European Symposium on Biochemical Engineering Sciences,
Lissabon, Portugal;
09-09-2018
- 09-12-2018; in: "Book of Abstracts",
(2018),
1 pages.
P. Kroll, S. Ulonska, J. Kager, C. Herwig:
"Ermöglichung kontinuierlicher Bioprozessführung durch Modelle, Data Science und PAT";
Talk: 13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion,
Esslingen, Deutschland (invited);
11-21-2017
- 11-22-2017; in: "Programm",
(2017),
39.
P. Sinner, J. Kager, S. Daume, C. Herwig:
"Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste";
Talk: FOSBE 2019 - 8th IFAC Conference on Foundations of Systems Biology in Engineering,
Valencia, Spanien;
10-15-2019
- 10-18-2019; in: "Program Booklet",
(2019),
22
- 23.
I. Stelzer, J. Kager, C. Herwig:
"Application of particle filter algorithms for monitoring of bioprocesses";
Talk: CEN ISBS Vienna 2017, Joint Conference on Biometrics & Biopharmaceutical Statistics,
Wien;
08-28-2017
- 09-01-2017; in: "Abstract Book",
(2017),
82.
Talks and Poster Presentations (without Proceedings-Entry)
S. Daume, J. Kager, C. Herwig:
"Time Resolved Sensitivity & Identifiability Analysis for Directed Parametrization of Highly Dynamic Models";
Poster: ESCAPE 29 - 29th European Symposium on Computer Aided Process Engineering,
Eindhoven, Niederlande;
06-16-2019
- 06-19-2019.
C. Herwig, J. Kager:
"Digital Twin Based Optimization of cell cultures";
Talk: EFCE Spotlight Talks (Online Conference),
Frankfurt am Main, Deutschland (invited);
11-23-2020
- 12-04-2020.
J. Kager, V. Berezhinskiy, R. Zimmerleitner, M. Brandstetter, C. Herwig:
"Extension of a Particle Filter for Bioprocess State Estimation using Invasive and Non-Invasive IR Measurements";
Talk: ESCAPE 29 - 29th European Symposium on Computer Aided Process Engineering,
Eindhoven, Niederlande;
06-16-2019
- 06-19-2019.
J. Kager, C. Herwig:
"Model based control of a penicillin production process";
Poster: BIOPRO World Talent Campus 2018,
Sorø, Dänemark (invited);
08-18-2018
- 08-22-2018.
J. Kager, I. Stelzer, C. Herwig:
"Improving Bioprocesses by Physiological Process Control";
Poster: Workshop on Methods for Accelerating Scalable Bioprocess Development,
Wien;
11-09-2016
- 11-11-2016.
J. Kager, S. Ulonska, P. Kroll, C. Herwig:
"Multi-parametric Control of Bioprocesses using Mechanistic Models";
Poster: ProcessNet-Jahrestagung und 32. DECHEMA-Jahrestagung der Biotechnologen 2016,
Aachen, Deutschland;
09-12-2016
- 09-15-2016.
P. Sinner, C. Herwig, J. Kager:
"Time scale analysis and optimization of a continuous microbial bioprocess";
Poster: ESCAPE 30 - 30th European Symposium on Computer Aided Process Engineering (Online Conference),
Mailand, Italien;
08-30-2020
- 09-02-2020.
I. Stelzer, J. Kager, C. Herwig:
"Comparison of Particle Filter and Extended Kalman Filter Algorithms for Monitoring of Bioprocesses";
Poster: Symposium on Computer Aided Process Engineering - ESCAPE 27,
Barcelona, Spanien;
10-01-2017
- 10-05-2017.
S. Ulonska, J. Kager, C. Herwig:
"Automatic controller failure detection with application in model based control of an E. coli fed-batch";
Talk: Escape28 - 28th European Symposium on Computer Aided Process Engineering,
Graz;
06-10-2018
- 06-13-2018.
Patents
W. Reichelt, C. Herwig, J. Kager, P. Sagmeister, M. Funke:
"Improved fermentation process";
Patent: Europa,
No. EP16158294.5;
submitted: 03-02-2016.
W. Reichelt, C. Herwig, J. Kager, P. Sagmeister, M. Funke:
"Improved Fermentation Process";
Patent: International,
No. Wo 2017/149065;
submitted: 03-02-2017.
Doctor's Theses (authored and supervised)
J. Kager:
"The Deployment of Mechanistic Models for Advanced Bioprocess Monitoring and Control";
Supervisor, Reviewer: C. Herwig, F. van der Berg, S. Jakubek;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
oral examination: 06-07-2019.
Diploma and Master Theses (authored and supervised)
V. Berezhinskiy:
"Comparison of different model-based observers for monitoring substrate and product concentrations in a Penicillium chrysogenum Fed-batch process";
Supervisor: C. Herwig, J. Kager;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
final examination: 04-03-2019.
J. Kager:
"Physiological Bioprocess Control: Constant specific substrate uptake rate in an antibody producing E. coli expression platform";
Supervisor: C. Herwig, W. Reichelt;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
final examination: 10-05-2015.
K. Lagoda:
"Bioprocess Control utilising Alternative Specific Rates";
Supervisor: C. Herwig, J. Kager, D. Wibbing;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2021;
final examination: 01-25-2021.
A. Tuveri:
"Model Based Control of Penicillium Chrysogenum Fed-Batch Process";
Supervisor: C. Herwig, J. Kager, S. Tronci;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
final examination: 09-25-2018.
Scientific Reports
J. Kager, J. Fricke, U. Becken, C. Herwig:
"A Generic Biomass Soft Sensor and Its Application in Bioprocess Development";
Report for Eppendorf AG;
Report No. 357,
2017;
8 pages.
J. Kager, C. Herwig, R. Holzer:
"imPACts Industrial Methods for Process Analytical Chemistry - From Measurement Technologies to Information Systems - "All-in-One: ein neuer Blick auf biochemische Prozesse"!";
Report for imPACts;
2017;
2 pages.
J. Kager, P. Sinner, H. Müller, C. Herwig:
"Real-time estimation of fungal biomass based on off gas analysis";
Report for BlueSens GmbH;
2019;
4 pages.