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Publication list for
Julian Kager
as author or essentially involved person

57 records (2015 - 2022)


Publications in Scientific Journals


D. Ehgartner, T. Hartmann, S. Heinzl, M. Frank, L. Veiter, J. Kager, C. Herwig, J. Fricke:
"Controlling the specific growth rate via biomass trend regulation in filamentous fungi bioprocesses";
Chemical Engineering Science, 172 (2017), 32 - 41.

O. Goldbeck, D. Desef, K. Ovchinnikov, F. Perez-Garcia, J. Christmann, P. Sinner, P. Crauwels, J. Kager, C. Herwig et al.:
"Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum";
Metabolic Engineering, 68 (2021), 34 - 45.

M. Jouned, J. Kager, C. Herwig, T. Barz:
"Event driven modeling for the accurate identification of metabolic switches in fed-batch culture of S. cerevisiae";
Biochemical Engineering Journal, 180 (2022).

J. Kager, J. Bartlehner, C. Herwig, S. Jakubek:
"Direct control of recombinant protein production rates in E. coli fed-batch processes by nonlinear feedback linearization";
Chemical Engineering Research and Design, 182 (2022), 290 - 304.

J. Kager, C. Herwig:
"Monte Carlo-Based Error Propagation for a More Reliable Regression Analysis across Specific Rates in Bioprocesses";
Bioengineering, 8 (2021), 160; 17 pages.

J. Kager, C. Herwig:
"Simulieren, Observieren, Kontrollieren - Vorhersage des Wachstumsverhaltens von Penicillium chrysogenum";
GIT Labor-Fachzeitschrift, 62 (2018), 8; 32 - 34.

J. Kager, C. Herwig, I. Stelzer:
"State estimation for a penicillin fed-batch process combining particle filtering methods with online and time delayed offline measurements";
Chemical Engineering Science, 177 (2018), 234 - 244.

J. Kager, A. Tuveri, S. Ulonska, P. Kroll, C. Herwig:
"Experimental verification and comparison of model predictive, PID and model inversion control in a Penicillium chrysogenum fed-batch process";
Process Biochemistry, 90 (2020), 1 - 11.

J. Kopp, C. Slouka, D. Strohmer, J. Kager, O. Spadiut, C. Herwig:
"Inclusion Body Bead Size in E. coli Controlled by Physiological Feeding";
Microorganisms, 6 (2018), 13 pages.

J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of Glycerol as Carbon Source onto Specific Sugar and Inducer Uptake Rates and Inclusion Body Productivity in E. coli BL21(DE3)";
Bioengineering, 5 (2018), 1; 15 pages.

P. Kroll, A. Hofer, S. Ulonska, J. Kager, C. Herwig:
"Model-Based Methods in the Biopharmaceutical Process Lifecycle";
Pharmaceutical Research, 34 (2017), 12; 2596 - 2613.

J. Pauk, J. Raju Palanisamy, J. Kager, K. Koczka, G. Berghammer, C. Herwig, L. Veiter:
"Advances in monitoring and control of refolding kinetics combining PAT and modeling";
Applied Microbiology and Biotechnology, 105 (2021), 2243 - 2260.

W. Reichelt, P. Thurrold, M. Brillmann, J. Kager, J. Fricke, C. Herwig:
"Generic biomass estimation methods targeting physiologic process control in induced bacterial cultures";
Engineering in Life Sciences, 16 (2016), 8; 720 - 730.

P. Sinner, J. Kager, S. Daume, C. Herwig:
"Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste";
IFAC PapersOnLine, 52 (2019), 26; 181 - 186.

P. Sinner, M. Stiegler, O. Goldbeck, G. Seibold, C. Herwig, J. Kager:
"Online estimation of changing metabolic capacities in continuous Corynebacterium glutamicum cultivations growing on a complex sugar mixture";
Biotechnology and Bioengineering, 119 (2022), 575 - 590.

P. Sinner, M. Stiegler, C. Herwig, J. Kager:
"Noninvasive online monitoring of Corynebacterium glutamicum fed-batch bioprocesses subject to spent sulfite liquor raw material uncertainty";
Bioresource Technology, 321 (2021).

C. Slouka, J. Kopp, D. Strohmer, J. Kager, O. Spadiut, C. Herwig:
"Monitoring and control strategies for inclusion body production in E. coli based on glycerol consumption";
Journal of Biotechnology, 296 (2019), 75 - 82.

S. Ulonska, D. Waldschitz, J. Kager, C. Herwig:
"Model predictive control in comparison to elemental balance control in an E. coli fed-batch";
Chemical Engineering Science, 191 (2018), 459 - 467.

L. Veiter, J. Kager, C. Herwig:
"Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed‑batch cultivations through morphological and physiological control";
Microbial Cell Factories, 19 (2020), 14 pages.

D. Zalai, J. Kopp, B. Kozma, M. Küchler, C. Herwig, J. Kager:
"Microbial technologies for biotherapeutics production: Key tools for advanced biopharmaceutical process development and control";
Drug Discovery Today: Technologies, 38 (2020), 9 - 24.

R. Zimmerleiter, J. Kager, R. Nikzad-Langerodi, V. Berezhinskiy, F. Westad, C. Herwig, M. Brandstetter:
"Probeless non-invasive near-infrared spectroscopic bioprocess monitoring using microspectrometer technology";
Analytical and Bioanalytical Chemistry, 412 (2020), 2103 - 2109.


Contributions to Books


T. Barz, J. Kager, C. Herwig, P. Neubauer, M. Cruz Bournazou, F. Galvanin:
"Characterization of reactions and growth in automated continuous flow and bioreactor platforms-From linear DoE to model-based approaches";
in: "Simulation and Optimization in Process Engineering", M. Bortz, N. Asprion (ed.); Elsevier Inc., Amsterdam, NL, 2022, ISBN: 978-0-323-85043-8, 273 - 319.

S. Daume, J. Kager, C. Herwig:
"Time Resolved Sensitivity & Identifiability Analysis for Directed Parametrization of Highly Dynamic Models";
in: "Computer Aided Chemical Engineering, 29th European Symposium on Computer Aided Process Engineering", 46; Elsevier, 2019, ISBN: 978-0-12-818634-3, 1111 - 1116.

S. Daume, S. Kofler, J. Kager, P. Kroll, C. Herwig:
"Generic Workflow for the Setup of Mechanistic Process Models";
in: "Animal Cell Biotechnology", Springer Science + Business Media, 2020, ISBN: 978-1-0716-0190-7, 189 - 211.

J. Kager, V. Berezhinskiy, R. Zimmerleitner, M. Brandstetter, C. Herwig:
"Extension of a Particle Filter for Bioprocess State Estimation using Invasive and Non-Invasive IR Measurements";
in: "Computer Aided Chemical Engineering, 29th European Symposium on Computer Aided Process Engineering", 46; Elsevier, 2019, ISBN: 978-0-12-818634-3, 1417 - 1422.

P. Sinner, S. Daume, C. Herwig, J. Kager:
"Usage of Digital Twins Along a Typical Process Development Cycle";
in: "Digital Twins - Tools and Concepts for Smart Biomanufacturing", C. Herwig, R. Pörtner, J. Möller (ed.); Springer International Publishing, 2021, ISBN: 978-3-030-71659-2.

P. Sinner, C. Herwig, J. Kager:
"Time Scale Analysis and Optimization of a Continuous Microbial Bioprocess";
in: "Computer Aided Chemical Engineering, 30th European Symposium on Computer Aided Process Engineering", 48; S. Pierucci, F. Manenti, G. Bozzano, D. Manca (ed.); Elsevier B.V., 2020, ISBN: 978-0-1282-3377-1, 1603 - 1608.

I. Stelzer, J. Kager, C. Herwig:
"Comparison of Particle Filter and Extended Kalman Filter Algorithms for Monitoring of Bioprocesses";
in: "Proceedings of the 27th European Symposium on Computer Aided Process Engineering - ESCAPE 27", 40; A. Espuña, M. Graells, L. Puigjaner (ed.); Elsevier B.V., 2017, ISBN: 978-0-444-63965-3, 1483 - 1488.

S. Ulonska, J. Kager, C. Herwig:
"Automatic controller failure detection with application in model based control of an E. coli fed-batch";
in: "Computer-Aided Chemical Engineering, Vol. 43 - 28th European Symposium on Computer Aided Process Engineering Part A", A. Friedl, J. Klemes, S. Radl, P. Varbanov, T. Wallek (ed.); Elsevier B.V., 2018, ISBN: 978-0-444-64237-0, 1673 - 1678.


Talks and Poster Presentations (with Proceedings-Entry)


T. Hardiman, M. Hofinger, P. Ettinger, G. Kornfeld, M. Weiner, P. Wechselberger, J. Buchholz, W. Riethorst, W. Skibar, J. Kager, I. Stelzer, A. Golabgir, D. Ehgartner, C. Herwig:
"Implementierung einer Softsenser-basierten Regelung eines großtechnischen Fermentationsprozesses";
Talk: 13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion, Esslingen, Deutschland; 11-21-2017 - 11-22-2017; in: "Programm", (2017), 50.

J. Kager:
"The deployment of mechanistic models in biotechnological production processes for advanced monitoring and control";
Talk: Corso di laurea in Ingegneria Chimica, Cagliari, Italien (invited); 09-27-2018; in: "http://people.unica.it/ingegneriachimica/2018/09/26/avviso-seminario-julian-kager/", (2018), 1 pages.

J. Kager, C. Herwig, V. Berezhinskiy:
"State estimation and control of bioprocesses based on mechanistic models";
Talk: IFPAC 2019 - 33rd International Forum and Exhibition on Process Analytical Chemistry (IFPAC) Annual Meeting, Washington D.C., USA; 03-03-2019 - 03-06-2019; in: "Abstracts", (2019), 1 pages.

J. Kager, S. Ulonska, F. Pollesböck, C. Herwig:
"Engineerīs Playground: Interfacing Students and Bioreactors for Teaching and Research";
Talk: VSS 2018 - Vienna Young Scientists Symposium, Wien; 06-07-2018 - 06-08-2018; in: "VSS 2018", Book-of-Abstracts.com, (2018), ISBN: 978-3-9504017-8-3; 64 - 65.

J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of glycerol as carbon source onto specific sugar and inducer uptake rates and inclusion body productivity in E. coli BL21 (DE3)";
Poster: 5th BioProScale Symposium, Berlin, Deutschland; 03-20-2018 - 03-22-2018; in: "Abstract Booklet", (2018), 48.

J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of glycerol as carbon source onto specific sugar and inducer uptake rates and inclusion body productivity in E. coli BL21(DE3)";
Talk: ESBES 2018 - European Symposium on Biochemical Engineering Sciences, Lissabon, Portugal; 09-09-2018 - 09-12-2018; in: "Book of Abstracts", (2018), 1 pages.

P. Kroll, S. Ulonska, J. Kager, C. Herwig:
"Ermöglichung kontinuierlicher Bioprozessführung durch Modelle, Data Science und PAT";
Talk: 13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion, Esslingen, Deutschland (invited); 11-21-2017 - 11-22-2017; in: "Programm", (2017), 39.

P. Sinner, J. Kager, S. Daume, C. Herwig:
"Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste";
Talk: FOSBE 2019 - 8th IFAC Conference on Foundations of Systems Biology in Engineering, Valencia, Spanien; 10-15-2019 - 10-18-2019; in: "Program Booklet", (2019), 22 - 23.

I. Stelzer, J. Kager, C. Herwig:
"Application of particle filter algorithms for monitoring of bioprocesses";
Talk: CEN ISBS Vienna 2017, Joint Conference on Biometrics & Biopharmaceutical Statistics, Wien; 08-28-2017 - 09-01-2017; in: "Abstract Book", (2017), 82.


Talks and Poster Presentations (without Proceedings-Entry)


S. Daume, J. Kager, C. Herwig:
"Time Resolved Sensitivity & Identifiability Analysis for Directed Parametrization of Highly Dynamic Models";
Poster: ESCAPE 29 - 29th European Symposium on Computer Aided Process Engineering, Eindhoven, Niederlande; 06-16-2019 - 06-19-2019.

C. Herwig, J. Kager:
"Digital Twin Based Optimization of cell cultures";
Talk: EFCE Spotlight Talks (Online Conference), Frankfurt am Main, Deutschland (invited); 11-23-2020 - 12-04-2020.

J. Kager, V. Berezhinskiy, R. Zimmerleitner, M. Brandstetter, C. Herwig:
"Extension of a Particle Filter for Bioprocess State Estimation using Invasive and Non-Invasive IR Measurements";
Talk: ESCAPE 29 - 29th European Symposium on Computer Aided Process Engineering, Eindhoven, Niederlande; 06-16-2019 - 06-19-2019.

J. Kager, C. Herwig:
"Model based control of a penicillin production process";
Poster: BIOPRO World Talent Campus 2018, Sorø, Dänemark (invited); 08-18-2018 - 08-22-2018.

J. Kager, I. Stelzer, C. Herwig:
"Improving Bioprocesses by Physiological Process Control";
Poster: Workshop on Methods for Accelerating Scalable Bioprocess Development, Wien; 11-09-2016 - 11-11-2016.

J. Kager, S. Ulonska, P. Kroll, C. Herwig:
"Multi-parametric Control of Bioprocesses using Mechanistic Models";
Poster: ProcessNet-Jahrestagung und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, Aachen, Deutschland; 09-12-2016 - 09-15-2016.

P. Sinner, C. Herwig, J. Kager:
"Time scale analysis and optimization of a continuous microbial bioprocess";
Poster: ESCAPE 30 - 30th European Symposium on Computer Aided Process Engineering (Online Conference), Mailand, Italien; 08-30-2020 - 09-02-2020.

I. Stelzer, J. Kager, C. Herwig:
"Comparison of Particle Filter and Extended Kalman Filter Algorithms for Monitoring of Bioprocesses";
Poster: Symposium on Computer Aided Process Engineering - ESCAPE 27, Barcelona, Spanien; 10-01-2017 - 10-05-2017.

S. Ulonska, J. Kager, C. Herwig:
"Automatic controller failure detection with application in model based control of an E. coli fed-batch";
Talk: Escape28 - 28th European Symposium on Computer Aided Process Engineering, Graz; 06-10-2018 - 06-13-2018.


Patents


W. Reichelt, C. Herwig, J. Kager, P. Sagmeister, M. Funke:
"Improved fermentation process";
Patent: Europa, No. EP16158294.5; submitted: 03-02-2016.

W. Reichelt, C. Herwig, J. Kager, P. Sagmeister, M. Funke:
"Improved Fermentation Process";
Patent: International, No. Wo 2017/149065; submitted: 03-02-2017.


Doctor's Theses (authored and supervised)


J. Kager:
"The Deployment of Mechanistic Models for Advanced Bioprocess Monitoring and Control";
Supervisor, Reviewer: C. Herwig, F. van der Berg, S. Jakubek; Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften, 2019; oral examination: 06-07-2019.


Diploma and Master Theses (authored and supervised)


V. Berezhinskiy:
"Comparison of different model-based observers for monitoring substrate and product concentrations in a Penicillium chrysogenum Fed-batch process";
Supervisor: C. Herwig, J. Kager; Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften, 2019; final examination: 04-03-2019.

J. Kager:
"Physiological Bioprocess Control: Constant specific substrate uptake rate in an antibody producing E. coli expression platform";
Supervisor: C. Herwig, W. Reichelt; Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften, 2015; final examination: 10-05-2015.

K. Lagoda:
"Bioprocess Control utilising Alternative Specific Rates";
Supervisor: C. Herwig, J. Kager, D. Wibbing; Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften, 2021; final examination: 01-25-2021.

A. Tuveri:
"Model Based Control of Penicillium Chrysogenum Fed-Batch Process";
Supervisor: C. Herwig, J. Kager, S. Tronci; Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften, 2018; final examination: 09-25-2018.


Scientific Reports


J. Kager, J. Fricke, U. Becken, C. Herwig:
"A Generic Biomass Soft Sensor and Its Application in Bioprocess Development";
Report for Eppendorf AG; Report No. 357, 2017; 8 pages.

J. Kager, C. Herwig, R. Holzer:
"imPACts Industrial Methods for Process Analytical Chemistry - From Measurement Technologies to Information Systems - "All-in-One: ein neuer Blick auf biochemische Prozesse"!";
Report for imPACts; 2017; 2 pages.

J. Kager, P. Sinner, H. Müller, C. Herwig:
"Real-time estimation of fungal biomass based on off gas analysis";
Report for BlueSens GmbH; 2019; 4 pages.