Publikationsliste für
Christoph Herwig
als Autorin / Autor bzw. wesentlich beteiligte Person
631 Datensätze (2008 - 2022)
Bücher und Buch-Herausgaben
T. Bannon, V. Cebular, P. Cicalese, B. Davis, L. Davis, N. Goldschmidt, C. Herwig et al.:
"Guide: ATMPs - Autologous Cell Therapy";
ISPE,
2021,
ISBN: 978-1-946964-49-6;
140 S.
C. Herwig (Hrg.):
"Hybrid Modelling and Multi- Parametric Control of Bioprocesses";
MDPI Ag, Basel, Switzerland,
2018,
ISBN: 978-3-03842-746-9;
140 S.
C. Herwig, R. Pörtner, J. Möller:
"Digital Twins - Applications to the Design and Optimization of Bioprocesses";
in Buchreihe "Advances in Biochemkal Engineering/Biotechnology",
Buchreihen-Herausgeber: T. Scheper;
Springer Nature Switzerland AG 2021,
Cham, Schweiz,
2021,
ISBN: 978-3-030-71655-4,
254 S.
C. Herwig, R. Pörtner, J. Möller:
"Digital Twins - Tools and Concepts for Smart Biomanufacturing";
in Buchreihe "Advances in Biochemical Engineering/Biotechnology",
Buchreihen-Herausgeber: T. Scheper;
Springer International Publishing,
2021,
ISBN: 978-3-030-71659-2,
240 S.
C. Slouka, C. Herwig, P. Neubauer, F. Delvigne:
"Continuous Biomanufacturing in Microbial Systems";
Frontiers,
Lausanne, Schweiz,
2021,
ISBN: 978-2-88971-120-8;
124 S.
M. Zinn, T. Egli, C. Herwig, A. Narang (Hrg.):
"Recent Advances in Continuous Cultivation";
Frontiers,
Lausanne, Schweiz,
2021,
ISBN: 978-2-88966-649-2;
133 S.
Zeitschriftenartikel
V. Abt, T. Barz, N. Cruz, C. Herwig, P. Kroll, J. Möller, R. Pörtner, R. Schenkendorf:
"Model-based tools for optimal experiments in bioprocess engineering";
Current Opinion in Chemical Engineering,
22
(2018),
S. 244
- 252.
V. Abt, T. Eifert, C. Herwig:
"AK Prozessanalytik (PAT)";
Mitteilungsblatt / Gesellschaft Deutscher Chemiker, Fachgruppe Analytische Chemie,
(2020),
1;
S. 19
- 21.
S. Bernacchi, C. Herwig:
"Challenges and Solutions For Development of Gas Limited Bioprocesses Illustrated By the Biological Methane Production (BMP) Process Development";
Current Biochemical Engineering,
3
(2016),
3;
S. 165
- 176.
S. Bernacchi, A. Krajete, C. Herwig:
"Experimental workflow for developing a feed forward strategy to control biomass growth and exploit maximum specific methane productivity of Methanothermobacter marburgensis in a biological methane production process (BMPP)";
Aims Microbiology,
2
(2016),
3;
S. 262
- 277.
S. Bernacchi, S. Rittmann, A. Seifert, A. Krajete, C. Herwig:
"Experimental methods for screening parameters influencing the growth to product yield (Y(x/CH4)) of a biological methane production (BMP) process performed with Methanothermobacter marburgensis";
AIMS Bioengineering,
1
(2014),
2;
S. 72
- 87.
S. Bernacchi, M. Weissgram, W. Wukovits, C. Herwig:
"Process efficiency simulation for key process parameters in biological methanogenesis";
AIMS Bioengineering,
1
(2014),
1;
S. 53
- 71.
K. Böttinger, W. Esser-Skala, M. Segl, C. Herwig, C. Huber:
"At-line quantitative profiling of monoclonal antibody products during bioprocessing using HPLC-MS";
Analytica Chimica Acta,
1207
(2022).
D. Borchert, D. Suarez‑Zuluaga, P. Sagmeister, Y. Thomassen, C. Herwig:
"Comparison of data science workflows for root cause analysis of bioprocesses";
Bioprocess and Biosystems Engineering,
42
(2019),
2;
S. 245
- 256.
D. Borchert, T. Zahel, Y. Thomassen, C. Herwig, D. Suarez‑Zuluaga:
"Quantitative CPP Evaluation from Risk Assessment Using Integrated Process Modeling";
Bioengineering,
6
(2019),
16 S.
M. Brandstetter, T. Sumalowitsch, A. Genner, A. Posch, C. Herwig, A. Drolz, V. Fuhrmann, T. Perkmann, B. Lendl:
"Reagent-free monitoring of multiple clinically relevant parameters in human blood plasma using a mid-infrared quantum cascade laser based sensor system";
Analyst,
138
(2013),
14;
S. 4022
- 4028.
Zusätzliche Informationen
M. Brunner, P. Braun, P. Doppler, C. Posch, D. Behrens, C. Herwig, J. Fricke:
"The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion";
Biotechnology Journal,
12
(2017),
7.
M. Brunner, P. Doppler, T. Klein, C. Herwig, J. Fricke:
"Elevated pCO2 affects the lactate metabolic shift in CHO cell culture processes";
Engineering in Life Sciences,
18
(2018),
S. 204
- 214.
M. Brunner, J. Fricke, P. Kroll, C. Herwig:
"Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes";
Bioprocess and Biosystems Engineering,
40
(2017),
2;
S. 251
- 263.
S. Capone, L. Corajevic, G. Bonifert, P. Murth, D. Maresch, F. Altmann, C. Herwig, O. Spadiut:
"Combining Protein and Strain Engineering for the Production of Glyco-Engineered Horseradish Peroxidase C1A in Pichia pastoris";
International Journal of Molecular Sciences,
16
(2015),
S. 23127
- 23142.
S. Capone, J. Horvat, C. Herwig, O. Spadiut:
"Development of a mixed feed strategy for a recombinant Pichia pastoris strain producing with a de-repression promoter";
Microbial Cell Factories,
14
(2015),
10 S.
S. Capone, R. Pletzenauer, D. Maresch, K. Metzger, F. Altmann, C. Herwig, O. Spadiut:
"Glyco-variant library of the versatile enzyme horseradish peroxidase";
Glycobiology,
24
(2014),
9;
S. 852
- 863.
S. Clara, A. Golabgir, M. Heinisch, C. Herwig, B. Jakoby:
"Bioprocess Monitoring using an Inline Viscosity Sensor";
Lenzinger Berichte,
92
(2015),
S. 6
- 11.
L. da Silva Amaral, E. Rodrigues-Filha, C.P. Kubicek, C. Herwig, M. Marchetti-Deschmann, G. Allmaier:
"Optimization of sample preparation for intact cell mass spectrometry (matrix‐assisted laser desorption/ionization linear time‐of‐flight mass spectrometry) of endophytic Xylaria";
Rapid Communications in Mass Spectrometry,
32
(2018),
S. 815
- 823.
G. Dahlgren, K. Macias, A. Moreira, D. Thompson, C. Herwig, R. Dream:
"Quality and Regulatory Solutions for PAT in Continuous Manufacturing";
Pharmaceutical Engineering,
34
(2020),
S. 52
- 60.
C. Dietzsch, O. Spadiut, C. Herwig:
"A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris";
Microbial Cell Factories,
10
(2011),
14;
9 S.
C. Dietzsch, O. Spadiut, C. Herwig:
"A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains";
Microbial Cell Factories,
10
(2011),
85;
10 S.
C. Dietzsch, O. Spadiut, C. Herwig:
"On-line multiple component analysis for efficient quantitative bioprocess development";
Journal of Biotechnology,
163
(2013),
S. 362
- 370.
P. Doppler, L. Veiter, O. Spadiut, C. Herwig, V. Rajamanickam:
"A Chemometric Tool to Monitor and Predict Cell Viability in Filamentous Fungi Bioprocesses Using UV Chromatogram Fingerprints";
Processes,
8
(2020),
15 S.
R. Dream, C. Herwig, E. Pelletier:
"Continuous Manufacturing in Biotech Processes - Challenges for Implementation";
Pharmaceutical Engineering,
38
(2018),
6;
S. 43
- 51.
I. Druzhinina, T. Laminger, D. Kamravamanesh, S. Pflügl, G. Mauschitz, R.L. Mach, C. Herwig, A. Friedl:
"Less plastic waste in the future";
Open Access Government,
16
(2017),
S. 312
- 313.
B. Eggenreich, V. Rajamanickam, D. Wurm, J. Fricke, C. Herwig, O. Spadiut:
"A combination of HPLC and automated data analysis for monitoring the efficiency of high‑pressure homogenization";
Microbial Cell Factories,
16
(2017),
10 S.
B. Eggenreich, M. Willim, D. Wurm, C. Herwig, O. Spadiut:
"Production strategies for active heme-containing peroxidases from E. coli inclusion bodies - a review";
Biotechnology Reports,
10
(2016),
S. 75
- 83.
D. Ehgartner, J. Fricke, A. Schröder, C. Herwig:
"At-line determining spore germination of Penicillium chrysogenum bioprocesses in complex media";
Applied Microbiology and Biotechnology,
100
(2016),
20;
S. 8923
- 8930.
D. Ehgartner, T. Hartmann, S. Heinzl, M. Frank, L. Veiter, J. Kager, C. Herwig, J. Fricke:
"Controlling the specific growth rate via biomass trend regulation in filamentous fungi bioprocesses";
Chemical Engineering Science,
172
(2017),
S. 32
- 41.
D. Ehgartner, C. Herwig, J. Fricke:
"Morphological analysis of the filamentous fungus Penicillium chrysogenum using flow cytometry-the fast alternative to microscopic image analysis";
Applied Microbiology and Biotechnology,
101
(2017),
20;
S. 7675
- 7688.
D. Ehgartner, C. Herwig, L. Neutsch:
"At-line determination of spore inoculum quality in Penicillium chrysogenum bioprocesses";
Applied Microbiology and Biotechnology,
100
(2016),
12;
S. 5363
- 5373.
D. Ehgartner, P. Sagmeister, C. Herwig, P. Wechselberger:
"A novel real-time method to estimate volumetric mass biodensity based on the combination of dielectric spectroscopy and soft-sensors";
Journal of Chemical Technology and Biotechnology,
90
(2015),
2;
S. 262
- 272.
D. Ehgartner, P. Sagmeister, T. Langemann, A. Meitz, W. Lubitz, C. Herwig:
"A novel method to recover inclusion body protein from recombinant E. coli fed-batch processes based on phage ΦX174-derived lysis protein E";
Applied Microbiology and Biotechnology,
101
(2017),
14;
S. 5603
- 5614.
T. Eifert, K. Eisen, M. Maiwald, C. Herwig:
"Current and future requirements to industrial analytical infrastructure-part 2: smart sensors";
Analytical and Bioanalytical Chemistry,
412
(2020),
S. 2037
- 2045.
K. Eisen, T. Eifert, C. Herwig, M. Maiwald:
"Current and future requirements to industrial analytical infrastructure-part 1: process analytical laboratories";
Analytical and Bioanalytical Chemistry,
412
(2020),
S. 2027
- 2035.
O. Garcia-Aponte, C. Herwig, B. Kozma:
"Lymphocyte expansion in bioreactors: upgrading adoptive cell therapy";
Journal of Biological Engineering,
15
(2021),
34 S.
F. Gattermayr, C. Herwig, V. Leitner:
"Effect of changes in continuous carboxylate feeding on the specific production rate of butanol using Clostridium saccharoperbutylacetonicum";
Bioresource Technology,
332
(2021).
C. Gmeiner, A. Saadati, D. Maresch, S. Krasteva, M. Frank, F. Altmann, C. Herwig, O. Spadiut:
"Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase";
Microbial Cell Factories,
14
(2015),
1;
10 S.
A. Golabgir, J. Gutierrez, H. Hefzi, S. Li, B. Palsson, C. Herwig, N. Lewis:
"Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow";
Biotechnology Advances,
34
(2016),
S. 621
- 633.
A. Golabgir, C. Herwig:
"Combining Mechanistic Modeling and Raman Spectroscopy for Real-Time Monitoring of Fed-Batch Penicillin Production";
Chemie Ingenieur Technik,
88
(2016),
6;
S. 764
- 776.
A. Golabgir, T. Hoch, M. Zhariy, C. Herwig:
"Observability Analysis of Biochemical Process Models as a Valuable Tool for the Development of Mechanistic Soft Sensors";
Biotechnology Progress,
31
(2016),
6;
S. 1703
- 1715.
O. Goldbeck, D. Desef, K. Ovchinnikov, F. Perez-Garcia, J. Christmann, P. Sinner, P. Crauwels, J. Kager, C. Herwig et al.:
"Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum";
Metabolic Engineering,
68
(2021),
S. 34
- 45.
M. Helmel, M. Marchetti-Deschmann, M. Raus, A. Posch, C. Herwig, M. Sebela, G. Allmaier:
"Intact cell mass spectrometry as a progress tracking tool for batch and fed-batch fermentation processes";
Analytical Biochemistry,
470
(2015),
S. 25
- 33.
M. Helmel, A. Posch, C. Herwig, G. Allmaier, M. Marchetti-Deschmann:
"Proteome profiling illustrated by a large-scalefed-batch fermentation of Penicillium chrysogenum";
EuPA Open Proteomics,
4
(2014),
4;
S. 113
- 120.
Zusätzliche Informationen
C. Herwig:
"Aktuelle Aspekte und Trends in der Biotechnologie";
Pharmazeutische Industrie,
71
(2009),
9;
S. 1600
- 1608.
C. Herwig:
"Fixing the Negative Perception of QbD";
The Medicine Maker,
(2015),
#0815/303;
2 S.
C. Herwig:
"Gewinnung von Wissen für eine effiziente und skalierbare Bioprozessentwicklung";
Technik in Bayern,
2
(2011),
1;
S. 18.
C. Herwig:
"Prozess Analytische Technologie in der Biotechnologie";
Chemie Ingenieur Technik,
82
(2010),
4;
S. 405
- 414.
C. Herwig:
"Psst, wir bauen für Rituximab! - Optimierung der Biopharmatechnologie durch innovative Brückenschläge";
Swiss Pharma,
38
(2016),
2;
S. 61
- 63.
C. Herwig:
"Softsensing für Bioprozesse";
CITplus,
19
(2016),
6;
S. 10.
C. Herwig, T. Eifert, M. Gerlach:
"AK Prozessanalytik (PAT)";
Mitteilungsblatt / Gesellschaft Deutscher Chemiker, Fachgruppe Analytische Chemie,
2
(2021),
S. 14
- 17.
C. Herwig, O. Garcia-Aponte, A. Golabgir, A. Rathore:
"Knowledge management in the QbD paradigm: manufacturing of biotech therapeutics";
Trends in Biotechnology,
33
(2015),
7;
S. 381
- 387.
C. Herwig, J. Glassey, N. Kockmann, K. Gernaey, M. Barolo:
"Better by Design";
The Chemical Engineer,
(2017),
915;
S. 41
- 43.
C. Herwig, N. Mahler:
"Aufreinigung salzbelasteter Abwässer mit halophilen Organismen";
Wasserwirtschaft Wassertechnik,
14
(2015),
Sonderausgabe Modernisierungsreport 2015/2016;
S. 30
- 33.
C. Herwig, F. Nygaard, M. Canzoneri, S. Springs, J. Wolfrum, R. Braatz, S. Kappeler, V. Steinwandter:
"DATA SCIENCE FOR PHARMA 4.0TM, Drug Development, and Production-Part 1";
Pharmaceutical Engineering,
41
(2021),
S. 40
- 47.
C. Herwig, A. Posch:
"Herausforderungen und Trends für zukünftige Bioprozesse";
Pharmazeutische Industrie,
75
(2013),
10;
S. 1688
- 1694.
C. Herwig, C. Wölbeling, T. Zimmer:
"A Holistic Approach to Production Control";
Pharmaceutical Engineering,
37
(2017),
3;
S. 44
- 49.
A. Hofer, S. Hauer, P. Kroll, J. Fricke, C. Herwig:
"In-depth characterization of the raw material corn steep liquor and its bioavailability in bioprocesses of Penicillium chrysogenum";
Process Biochemistry,
70
(2018),
S. 20
- 28.
A. Hofer, S. Hauer, P. Kroll, C. Herwig:
"Metabolic flux analysis linked to complex raw materials as tool for bioprocess improvement";
Chemical Engineering Science,
191
(2018),
S. 245
- 252.
A. Hofer, C. Herwig:
"Quantitative determination of nine water-soluble vitamins in the complex matrix of corn steep liquor for rawmaterial quality assessment";
Journal of Chemical Technology and Biotechnology,
92
(2017),
8;
S. 2106
- 2113.
A. Hofer, C. Herwig, O. Spadiut:
"Lecithin is the key material attribute in soy bean oil affecting filamentous bioprocesses";
AMB Express,
8
(2018),
8 S.
A. Hofer, D. Kamravamanesh, J. Bona-Lovasz, A. Limbeck, B. Lendl, C. Herwig, J. Fricke:
"Prediction of filamentous process performance attributes by CSL quality assessment using mid-infrared spectroscopy and chemometrics";
Journal of Biotechnology,
265
(2018),
S. 93
- 100.
A. Hofer, P. Kroll, M. Barmettler, C. Herwig:
"A Reliable Automated Sampling System for On-Line and Real-Time Monitoring of CHO Cultures";
Processes,
8
(2020),
8;
17 S.
M. Jazini, G. Cekici, C. Herwig:
"Quantifying the Effects of Frequency and Amplitude of Periodic Oxygen-Related Stress on Recombinant Protein Production in Pichia pastoris";
Bioengineering,
1
(2014),
1;
S. 47
- 61.
M. Jazini, C. Herwig:
"Effect of post-induction substrate oscillation on recombinant alkaline phosphatase production expressed in Escherichia coli";
Journal of Bioscience and Bioengineering,
112
(2011),
6;
S. 606
- 610.
M. Jazini, C. Herwig:
"Effects of temperature shifts and oscillations on recombinant protein production expressed in Escherichia coli";
Bioprocess and Biosystems Engineering,
36
(2013),
S. 1571
- 1577.
M. Jazini, C. Herwig:
"Substrate oscillations boost recombinant protein release from Escherichia coli";
Bioprocess and Biosystems Engineering,
37
(2014),
S. 881
- 890.
M. Jouned, J. Kager, C. Herwig, T. Barz:
"Event driven modeling for the accurate identification of metabolic switches in fed-batch culture of S. cerevisiae";
Biochemical Engineering Journal,
180
(2022).
J. Kager, J. Bartlehner, C. Herwig, S. Jakubek:
"Direct control of recombinant protein production rates in E. coli fed-batch processes by nonlinear feedback linearization";
Chemical Engineering Research and Design,
182
(2022),
S. 290
- 304.
J. Kager, C. Herwig:
"Monte Carlo-Based Error Propagation for a More Reliable Regression Analysis across Specific Rates in Bioprocesses";
Bioengineering,
8
(2021),
160;
17 S.
J. Kager, C. Herwig:
"Simulieren, Observieren, Kontrollieren - Vorhersage des Wachstumsverhaltens von Penicillium chrysogenum";
GIT Labor-Fachzeitschrift,
62
(2018),
8;
S. 32
- 34.
J. Kager, C. Herwig, I. Stelzer:
"State estimation for a penicillin fed-batch process combining particle filtering methods with online and time delayed offline measurements";
Chemical Engineering Science,
177
(2018),
S. 234
- 244.
J. Kager, A. Tuveri, S. Ulonska, P. Kroll, C. Herwig:
"Experimental verification and comparison of model predictive, PID and model inversion control in a Penicillium chrysogenum fed-batch process";
Process Biochemistry,
90
(2020),
S. 1
- 11.
D. Kamravamanesh, T. Kovacs, S. Pflügl, I. Druzhinina, P. Kroll, M. Lackner, C. Herwig:
"Increased poly-β-hydroxybutyrate production from carbon dioxide in randomly mutated cells of cyanobacterial strain Synechocystis sp. PCC 6714: Mutant generation and characterization";
Bioresource Technology,
266
(2018),
S. 34
- 44.
D. Kamravamanesh, M. Lackner, C. Herwig:
"Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria";
Bioengineering,
5
(2018),
18 S.
D. Kamravamanesh, S. Pflügl, W. Nischkauer, A. Limbeck, M. Lackner, C. Herwig:
"Photosynthetic poly‑β‑hydroxybutyrate accumulation in unicellular cyanobacterium Synechocystis sp. PCC 6714";
AMB Express,
7
(2017),
12 S.
D. Kamravamanesh, C. Slouka, A. Limbeck, M. Lackner, C. Herwig:
"Increased carbohydrate production from carbon dioxide in randomly mutated cells of cyanobacterial strain Synechocystis sp. PCC 6714: Bioprocess understanding and evaluation of productivities";
Bioresource Technology,
273
(2019),
S. 277
- 287.
S. Kappeler, F. Nygaard, M. Canzoneri, S. Springs, J. Wolfrum, R. Braatz, V. Steinwandter, C. Herwig:
"DATA SCIENCE FOR PHARMA 4.0TM, Drug Development, and Production-Part 2";
Pharmaceutical Engineering,
41
(2021),
3;
S. 43
- 49.
S. Kittler, C. Slouka, A. Pell, R. Lamplot, M. Besleaga, S. Ablasser, C. Herwig, O. Spadiut, J. Kopp:
"Cascaded processing enables continuous upstream processing with E. coli BL21(DE3)";
Scientific Reports,
11
(2021),
11 S.
T. Klein, N. Heinzel, P. Kroll, M. Brunner, C. Herwig, L. Neutsch:
"Quantification of cell lysis during CHO bioprocesses: Impact on cell count, growth kinetics and productivity";
Journal of Biotechnology,
207
(2015),
S. 67
- 76.
C. Koch, M. Brandstätter, P. Wechselberger, B. Lorantfy, M. R. Plata Torres, S. Radel, C. Herwig, B. Lendl:
"Ultrasound-Enhanced Attenuated Total Reflection Mid-infrared Spectroscopy In-Line Probe: Acquisition of Cell Spectra in a Bioreactor";
Analytical Chemistry,
87
(2015),
S. 2314
- 2320.
C. Koch, A. Posch, H. Goicoechea, C. Herwig, B. Lendl:
"Multi-analyte quantification in bioprocesses by Fourier-transform-infrared spectroscopy by partial least squares regression and multivariate curve resolution";
Analytica Chimica Acta,
807
(2014),
S. 103
- 110.
C. Koch, A. Posch, C. Herwig, B. Lendl:
"Comparison of Fiber Optic and Conduit Attenuated Total Reflection (ATR) Fourier Transform Infrared (FT-IR) Setup for In-Line Fermentation Monitoring";
Applied Spectroscopy,
70
(2016),
12;
S. 1965
- 1973.
V. Konakovsky, C. Clemens, M. Müller, J. Bechmann, M. Berger, S. Schlatter, C. Herwig:
"Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness";
Bioengineering,
3
(2016),
1;
29 S.
V. Konakovsky, C. Clemens, M. Müller, J. Bechmann, C. Herwig:
"A Robust Feeding Strategy to Maintain Set-Point Glucose in Mammalian Fed-Batch Cultures When Input Parameters Have a Large Error";
Biotechnology Progress,
33
(2017),
2;
S. 317
- 336.
V. Konakovsky, A. Yagtu, C. Clemens, M. Müller, M. Berger, S. Schlatter, C. Herwig:
"Universal Capacitance Model for Real-Time Biomass in Cell Culture";
Sensors,
15
(2015),
S. 22128
- 22150.
J. Kopp, S. Kittler, C. Slouka, C. Herwig, O. Spadiut, D. Wurm:
"Repetitive Fed-Batch: A Promising Process Mode for Biomanufacturing With E. coli";
Frontiers in Bioengineering and Biotechnology,
8
(2020),
13 S.
J. Kopp, A. Kolkmann, P. Veleenturf, O. Spadiut, C. Herwig, C. Slouka:
"Boosting Recombinant Inclusion Body Production-From Classical Fed-Batch Approach to Continuous Cultivation";
Frontiers in Bioengineering and Biotechnology,
7
(2019),
12 S.
J. Kopp, C. Slouka, O. Spadiut, C. Herwig:
"The Rocky Road From Fed-Batch to Continuous Processing With E. coli";
Frontiers in Bioengineering and Biotechnology,
7
(2019),
16 S.
J. Kopp, C. Slouka, D. Strohmer, J. Kager, O. Spadiut, C. Herwig:
"Inclusion Body Bead Size in E. coli Controlled by Physiological Feeding";
Microorganisms,
6
(2018),
13 S.
J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of Glycerol as Carbon Source onto Specific Sugar and Inducer Uptake Rates and Inclusion Body Productivity in E. coli BL21(DE3)";
Bioengineering,
5
(2018),
1;
15 S.
J. Kopp, F. Zauner, A. Pell, J. Hausjell, D. Humer, J. Ebner, C. Herwig, O. Spadiut, C. Slouka, R. Pell:
"Development of a generic reversed-phase liquid chromatography method for protein quantification using analytical quality-by-design principles";
Journal of Pharmaceutical and Biomedical Analysis,
188
(2020).
F. Krainer, S. Capone, M. Jäger, T. Vogl, M. Gerstmann, A. Glieder, C. Herwig, O. Spadiut:
"Optimizing cofactor availability for the production of recombinant heme peroxidase in Pichia pastoris";
Microbial Cell Factories,
14
(2015),
4;
9 S.
F. Krainer, C. Dietzsch, T. Hajek, C. Herwig, O. Spadiut, A. Glieder:
"Recombinant protein expression in Pichia pastoris strains with an engineered methanol utilization pathway";
Microbial Cell Factories,
11
(2012),
22;
14 S.
Zusätzliche Informationen
F. Krainer, C. Gmeiner, L. Neutsch, M. Windwarder, R. Pletzenauer, C. Herwig, F. Altmann, A. Glieder, O. Spadiut:
"Knockout of an endogenous mannosyltransferase increases the homogeneity of glycoproteins produced in Pichia pastoris";
Scientific Reports,
3
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13 S.
F. Krainer, R. Pletzenauer, L. Rosetti, C. Herwig, A. Glieder, O. Spadiut:
"Purification and basic biochemical characterization of 19 recombinant plant peroxidase isoenzymes produced in Pichia pastoris";
Protein Expression and Purification,
95
(2014),
S. 104
- 112.
P. Kroll, K. Eilers, J. Fricke, C. Herwig:
"Impact of cell lysis on the description of cell growth and death in cell culture";
Engineering in Life Sciences,
17
(2017),
4;
S. 440
- 447.
P. Kroll, A. Hofer, I. Stelzer, C. Herwig:
"Workflow to set up substantial target-oriented mechanistic process models in bioprocess engineering";
Process Biochemistry,
62
(2017),
S. 24
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P. Kroll, A. Hofer, S. Ulonska, J. Kager, C. Herwig:
"Model-Based Methods in the Biopharmaceutical Process Lifecycle";
Pharmaceutical Research,
34
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P. Kroll, P. Sagmeister, W. Reichelt, L. Neutsch, T. Klein, C. Herwig:
"Ex situ online monitoring: application, challenges and opportunities for biopharmaceuticals processes";
Pharmaceutical Bioprocessing,
2
(2014),
3;
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- 300.
P. Kroll, I. Stelzer, C. Herwig:
"Soft sensor for monitoring biomass subpopulations in mammalian cell culture processes";
Biotechnology Letters,
39
(2017),
11;
S. 1667
- 1673.
J. Kuligowski, G. Quintas, C. Herwig, B. Lendl:
"A rapid method for the differentiation of yeast cells grown under carbon and nitrogen-limited conditions by means of partial least squares discriminant analysis employing infrared micro-spectroscopic data of entire yeast cells";
Talanta,
99
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S. 566
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Zusätzliche Informationen
T. Langemann, U. Mayr, A. Meitz, W. Lubitz, C. Herwig:
"Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production";
Applied Microbiology and Biotechnology,
100
(2016),
S. 409
- 418.
B. Lorantfy, C. Herwig:
"Integrated bioprocess development with extreme halophiles for carotenoid production";
Carotenoid Science,
18
(2014),
S. 49.
B. Lorantfy, M. Jazini, C. Herwig:
"Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut+ strain using a two-compartment scale-down system";
Journal of Bioscience and Bioengineering,
116
(2013),
3;
S. 371
- 379.
B. Lorantfy, T. Renkecz, C. Koch, G. Horvai, B. Lendl, C. Herwig:
"Identification of lipophilic bioproduct portfolio from bioreactor samples of extreme halophilic archaea with HPLC-MS/MS";
Analytical and Bioanalytical Chemistry,
406
(2014),
9 -10;
S. 2421
- 2432.
B. Lorantfy, P. Ruschitzka, C. Herwig:
"Investigation of physiological limits and conditions for robustbioprocessing of an extreme halophilic archaeon using externalcell retention system";
Biochemical Engineering Journal,
90
(2014),
S. 140
- 148.
B. Lorantfy, B. Seyer, C. Herwig:
"Dynamic Experiments for Bioprocess Parameter Optimization with Extreme Halophilic Archaea";
Bioengineering,
1
(2014),
1;
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- 17.
B. Lorantfy, B. Seyer, C. Herwig:
"Stoichiometric and kinetic analysis of extreme halophilic Archaea on various substrates in a corrosion resistant bioreactor";
New Biotechnology,
31
(2014),
1;
S. 80
- 89.
P. Luoma, A. Golabgir, M. Brandstetter, J. Kasberger, C. Herwig:
"Workflow for multi-analyte bioprocess monitoring demonstrated on inline NIR spectroscopy of P. chrysogenum fermentation";
Analytical and Bioanalytical Chemistry,
409
(2017),
S. 797
- 805.
N. Mahler, S. Tschirren, S. Pflügl, C. Herwig:
"Optimized bioreactor setup for scale-up studies of extreme halophilic cultures";
Biochemical Engineering Journal,
130
(2018),
S. 39
- 46.
T. Mainka, C. Herwig, S. Pflügl:
"Bioprocess development for continuous treatment of industrial waste salt water";
Chemie Ingenieur Technik,
92
(2020),
9;
S. 1228.
T. Mainka, C. Herwig, S. Pflügl:
"Reducing Organic Load From Industrial Residual Process Brine With a Novel Halophilic Mixed Culture: Scale-Up and Long-Term Piloting of an Integrated Bioprocess";
Frontiers in Bioengineering and Biotechnology,
10
(2022),
13 S.
T. Mainka, N. Mahler, C. Herwig, S. Pflügl:
"Soft Sensor-Based Monitoring and Efficient Control Strategies of Biomass Concentration for Continuous Cultures of Haloferax mediterranei and Their Application to an Industrial Production Chain";
Microorganisms,
7
(2019),
14 S.
T. Mainka, D. Weirathmüller, C. Herwig, S. Pflügl:
"Potential applications of halophilic microorganisms for biological treatment of industrial process brines contaminated with aromatics";
Journal of Industrial Microbiology & Biotechnology,
48
(2021),
1-2;
19 S.
L. Marschall, P. Sagmeister, C. Herwig:
"Tunable recombinant protein expression in E. coli: enabler for continuous processing?";
Applied Microbiology and Biotechnology,
100
(2016),
S. 5719
- 5728.
L. Marschall, P. Sagmeister, C. Herwig:
"Tunable recombinant protein expression in E. coli: promoter systems and genetic constraints";
Applied Microbiology and Biotechnology,
101
(2017),
S. 501
- 512.
E. Martinez Porqueras, S. Rittmann, C. Herwig:
"Analysis of H2 to CO2 yield and physiological key parameters of Enterobacter aerogens and Caldicellulosiruptor saccharolyticus";
International Journal of Hydrogen Energy,
38
(2013),
S. 10245
- 10251.
E. Martinez Porqueras, S. Rittmann, C. Herwig:
"Biofuels and CO2 neutrality : an opportunity";
Biofuels,
3
(2012),
4;
S. 413
- 426.
E. Martinez Porqueras, P. Wechselberger, C. Herwig:
"Effect of medium composition on biohydrogen production by the extreme thermophilic bacterium Caldicellulosiruptor saccharolyticus";
International Journal of Hydrogen Energy,
38
(2013),
S. 11756
- 11764.
A. Meitz, P. Sagmeister, T. Langemann, C. Herwig:
"An Integrated Downstream Process Development Strategy along QbD Principles";
Bioengineering,
1
(2014),
S. 213
- 230.
A. Meitz, P. Sagmeister, W. Lubitz, C. Herwig, T. Langemann:
"Fed-Batch Production of Bacterial Ghosts Using Dielectric Spectroscopy for Dynamic Process Control";
Microorganisms,
4
(2016),
2;
15 S.
S. Mittermair, J. Richter, P. Doppler, K. Trenzinger, C. Nicoletti, C. Forsich, O. Spadiut, C. Herwig, M. Lackner:
"Impact of exoD gene knockout on the polyhydroxybutyrate overaccumulating mutant Mt_a24";
International Journal of Biobased Plastics,
3
(2021),
1;
S. 1
- 18.
L. Neutsch, P. Kroll, M. Brunner, A. Pansy, M. Kovar, C. Herwig, T. Klein:
"Media photo-degradation in pharmaceutical biotechnology - impact of ambient light on media quality, cell physiology, and IgG production in CHO cultures";
Journal of Chemical Technology and Biotechnology,
93
(2018),
8;
S. 2141
- 2151.
T. Nguyen, S. Telek, A. Zicler, J. Martinez, B. Zacchetti, J. Kopp, C. Slouka, C. Herwig, A. Grünberger, F. Delvigne:
"Reducing phenotypic instabilities of a microbial population during continuous cultivation based on cell switching dynamics";
Biotechnology and Bioengineering,
118
(2021),
10;
S. 3847
- 3859.
R. Nikzad-Langerodi, E. Lughofer, S. Saminger-Platz, T. Zahel, P. Sagmeister, C. Herwig:
"Automatic feed phase identification in multivariate bioprocess profiles by sequential binary classification";
Analytica Chimica Acta,
982
(2017),
S. 48
- 61.
W. Nischkauer, F. Vanhaecke, S. Bernacchi, C. Herwig, A. Limbeck:
"Radial line-scans as representative sampling strategy in dried-droplet laser ablation of liquid samples deposited on pre-cut filter paper disks";
Spectrochimica Acta Part B,
101
(2014),
S. 123
- 129.
Zusätzliche Informationen
K. Novak, L. Flöckner, A. Erian, P. Freitag, C. Herwig, S. Pflügl:
"Characterizing the effect of expression of an acetyl‑CoA synthetase insensitive to acetylation on co‑utilization of glucose and acetate in batch and continuous cultures of E. coli W";
Microbial Cell Factories,
17
(2018),
15 S.
J. Pauk, J. Raju Palanisamy, J. Kager, K. Koczka, G. Berghammer, C. Herwig, L. Veiter:
"Advances in monitoring and control of refolding kinetics combining PAT and modeling";
Applied Microbiology and Biotechnology,
105
(2021),
S. 2243
- 2260.
K. Paul, K. Böttinger, B. Mitic, G. Scherfler, C. Posch, D. Behrens, C. Huber, C. Herwig:
"Development, characterization, and application of a 2-Compartment system to investigate the impact of pH inhomogeneities in large-scale CHO-based processes";
Engineering in Life Sciences,
20
(2020),
8;
S. 368
- 378.
K. Paul, T. Hartmann, C. Posch, D. Behrens, C. Herwig:
"Investigation of cell line specific responses to pH inhomogeneity and consequences for process design";
Engineering in Life Sciences,
20
(2020),
9-10;
S. 412
- 421.
K. Paul, C. Herwig:
"Scale-down simulators for mammalian cell culture as tools to access the impact of inhomogeneities occurring in large-scale bioreactors";
Engineering in Life Sciences,
20
(2020),
5-6;
S. 197
- 204.
K. Paul, V. Rajamanickam, C. Herwig:
"Model-based optimization of temperature and pH shift to increase volumetric productivity of a Chinese hamster ovary fed-batch process";
Journal of Bioscience and Bioengineering,
128
(2019),
6;
S. 710
- 715.
A. Pekarsky, L. Veiter, V. Rajamanickam, C. Herwig, C. Grünwald-Huber, F. Altmann, O. Spadiut:
"Production of a recombinant peroxidase in different glyco‑engineered Pichia pastoris strains: a morphological and physiological comparison";
Microbial Cell Factories,
17
(2018),
15 S.
M. R. Plata Torres, C. Koch, P. Wechselberger, C. Herwig, B. Lendl:
"Determination of carbohydrates present in Saccharomyces cerevisiae using mid-infrared spectroscopy and partial least squares regression";
Analytical and Bioanalytical Chemistry,
405
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25;
S. 8241
- 8250.
A. Posch, M. Helmel, C. Koch, M. Marchetti-Deschmann, B. Lendl, G. Allmaier, C. Herwig:
"A comprehensive toolbox for morphological and physiological bioprocess characterisation of filamentous fungi";
Chemie Ingenieur Technik,
84
(2012),
8;
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- 1339.
A. Posch, C. Herwig, O. Spadiut:
"Science-based bioprocess design for filamentous fungi";
Trends in Biotechnology,
31
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1;
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- 44.
A. Posch, C. Koch, M. Helmel, M. Marchetti-Deschmann, K. Macfelda, B. Lendl, G. Allmaier, C. Herwig:
"Combining light microscopy, dielectric spectroscopy, MALDI intact cell mass spectrometry, FTIR spectromicroscopy and multivariate data mining for morphological and physiological bioprocess characterization of filamentous organisms";
Fungal Genetics and Biology,
51
(2013),
S. 1
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A. Posch, O. Spadiut, C. Herwig:
"A novel method for fast and statistically verified morphological characterization of filamentous fungi";
Fungal Genetics and Biology,
49
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S. 499
- 510.
A. Posch, O. Spadiut, C. Herwig:
"Switching industrial production processes from complex to defined media : method development and case study using the example of Penicillium chrysogenum";
Microbial Cell Factories,
11
(2012),
14 S.
B. Pretzner, R. Maschke, C. Haiderer, G. John, C. Herwig, P. Sykacek:
"Predictive Monitoring of Shake Flask Cultures with Online Estimated Growth Models";
Bioengineering,
8
(2021),
177;
24 S.
V. Rajamanickam, C. Herwig, O. Spadiut:
"A Generic Workflow for Bioprocess Analytical Data: Screening Alignment Techniques and Analyzing their Effects on Multivariate Modeling";
Biochemistry & Analytical Biochemistry,
8
(2019),
1;
11 S.
V. Rajamanickam, C. Herwig, O. Spadiut:
"Monoliths in Bioprocess Technology";
Chromatography,
2
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S. 195
- 212.
V. Rajamanickam, M. Krippl, C. Herwig, O. Spadiut:
"An automated data-driven DSP development approach for glycoproteins from yeast";
Electrophoresis,
38
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S. 2886
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V. Rajamanickam, O. Spadiut, C. Herwig:
"Data Science, Modeling, and Advanced PAT Tools Enable Continuous Culture";
BioProcess International,
16
(2018),
4;
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- 25.
V. Rajamanickam, M. Winkler, P. Flotz, L. Meyer, C. Herwig, O. Spadiut:
"Comparison of Purification Strategies of Three Horseradish Peroxidase Isoenzymes Recombinantly Produced in Pichia pastoris";
Journal of Chromatography & Separation Techniques,
7
(2016),
1;
6 S.
V. Rajamanickam, D. Wurm, C. Slouka, C. Herwig, O. Spadiut:
"A novel toolbox for E. coli lysis monitoring";
Analytical and Bioanalytical Chemistry,
409
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S. 667
- 671.
A. Rathore, O. Garcia-Aponte, A. Golabgir, B. Vallejo-Diaz, C. Herwig:
"Role of Knowledge Management in Development and Lifecycle Management of Biopharmaceuticals";
Pharmaceutical Research,
34
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2;
S. 243
- 256.
W. Reichelt, M. Brillmann, P. Thurrold, P. Keil, J. Fricke, C. Herwig:
"Physiological capacities decline during induced bioprocesses leading to substrate accumulation";
Biotechnology Journal,
12
(2017),
7.
W. Reichelt, A. Kaineder, M. Brillmann, L. Neutsch, A. Taschauer, J. Lohninger, C. Herwig:
"High throughput inclusion body sizing: Nano particle tracking analysis";
Biotechnology Journal,
12
(2017),
6.
W. Reichelt, P. Thurrold, M. Brillmann, J. Kager, J. Fricke, C. Herwig:
"Generic biomass estimation methods targeting physiologic process control in induced bacterial cultures";
Engineering in Life Sciences,
16
(2016),
8;
S. 720
- 730.
W. Reichelt, D. Waldschitz, C. Herwig, L. Neutsch:
"Bioprocess monitoring: minimizing sample matrix effects for total protein quantification with bicinchoninic acid assay";
Journal of Industrial Microbiology & Biotechnology,
43
(2016),
S. 1271
- 1280.
H. Reinsch, O. Spadiut, J. Heidingsfelder, C. Herwig:
"Examining the freezing process of an intermediate bulk containing an industrially relevant protein";
Enzyme and Microbial Technology,
71
(2015),
S. 13
- 19.
M. Rios, C. Herwig, L. Graham, P. Satzer:
"Developing Process Control Strategies for Continuous Bioprocesses";
BioProcess International,
18
(2020),
5;
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- 16.
S. Rittmann, C. Herwig:
"A comprehensive and quantitative review of dark fermentative biohydrogen production";
Microbial Cell Factories,
11
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115;
18 S.
S. Rittmann, A. Seifert, C. Herwig:
"Essential prerequisites for successful bioprocess development of biological CH4 production from CO2 and H2";
CRC Critical Reviews in Biotechnology,
33
(2013),
11 S.
S. Rittmann, A. Seifert, C. Herwig:
"Quantitative analysis of media dilution rate effects on Methanothermobacter marburgensis grown in continuous culture on H2 and CO2";
Biomass & Bioenergy,
36
(2012),
S. 293
- 301.
P. Sagmeister, M. Kment, P. Wechselberger, A. Meitz, T. Langemann, C. Herwig:
"Soft-sensor assisted dynamic investigation of mixed feed bioprocesses";
Process Biochemistry,
48
(2013),
S. 1839
- 1847.
P. Sagmeister, T. Langemann, P. Wechselberger, A. Meitz, C. Herwig:
"A dynamic method for the investigation of induced state metabolic capacities as a function of temperature";
Microbial Cell Factories,
12
(2013),
11 S.
P. Sagmeister, C. Schimek, A. Meitz, C. Herwig, O. Spadiut:
"Tunable recombinant protein expression with E. coli in a mixed-feed environment";
Applied Microbiology and Biotechnology,
98
(2014),
S. 2937
- 2945.
P. Sagmeister, P. Wechselberger, C. Herwig:
"Information Processing : Rate-Based Investigation of Cell Physiological Changes along Design Space Development";
PDA Journal of pharmaceutical Science and Technology,
66
(2012),
S. 526
- 541.
P. Sagmeister, P. Wechselberger, M. Jazini, A. Meitz, T. Langemann, C. Herwig:
"Soft sensor assisted dynamic bioprocess control : Efficient tools for bioprocess development";
Chemical Engineering Science,
96
(2013),
S. 190
- 198.
A. Schwaighofer, S. Ablasser, L. Lux, J. Kopp, C. Herwig, O. Spadiut, B. Lendl, C. Slouka:
"Production of Active Recombinant Hyaluronidase Inclusion Bodies from Apis mellifera in E. coli Bl21(DE3) and characterization by FT-IR Spectroscopy";
International Journal of Molecular Sciences,
21
(2020),
11;
14 S.
A. Seifert, S. Rittmann, S. Bernacchi, C. Herwig:
"Method for assessing the impact of emission gasses on physiology and productivity in biological methanogenesis";
Bioresource Technology,
136
(2013),
S. 747
- 751.
A. Seifert, S. Rittmann, C. Herwig:
"Analysis of process related factors to increase volumetric productivity and quality of biomethane with Methanothermobacter marburgensis";
Applied Energy,
132
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S. 155
- 162.
A. Seifert, S. Rittmann, C. Herwig:
"Influence of gas/liquid mass transfer on the volumetric production rate and product quality during biological methanogenesis";
Chemie Ingenieur Technik,
84
(2012),
8;
S. 1198.
P. Sinner, J. Kager, S. Daume, C. Herwig:
"Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste";
IFAC PapersOnLine,
52
(2019),
26;
S. 181
- 186.
P. Sinner, M. Stiegler, O. Goldbeck, G. Seibold, C. Herwig, J. Kager:
"Online estimation of changing metabolic capacities in continuous Corynebacterium glutamicum cultivations growing on a complex sugar mixture";
Biotechnology and Bioengineering,
119
(2022),
S. 575
- 590.
P. Sinner, M. Stiegler, C. Herwig, J. Kager:
"Noninvasive online monitoring of Corynebacterium glutamicum fed-batch bioprocesses subject to spent sulfite liquor raw material uncertainty";
Bioresource Technology,
321
(2021).
C. Slouka, G. Brunauer, J. Kopp, M. Strahammer, J. Fricke, J. Fleig, C. Herwig:
"Low-Frequency Electrochemical Impedance Spectroscopy as a Monitoring Tool for Yeast Growth in Industrial Brewing Processes";
Chemosensors,
5
(2017),
3;
14 S.
C. Slouka, J. Kopp, S. Hutwimmer, M. Strahammer, D. Strohmer, E. Eitenberger, A. Schwaighofer, C. Herwig:
"Custom made inclusion bodies: impact of classical process parameters and physiological parameters on inclusion body quality attributes";
Microbial Cell Factories,
17
(2018),
15 S.
C. Slouka, J. Kopp, O. Spadiut, C. Herwig:
"Perspectives of inclusion bodies for bio-based products: curse or blessing?";
Applied Microbiology and Biotechnology,
103
(2019),
3;
S. 1143
- 1153.
C. Slouka, J. Kopp, D. Strohmer, J. Kager, O. Spadiut, C. Herwig:
"Monitoring and control strategies for inclusion body production in E. coli based on glycerol consumption";
Journal of Biotechnology,
296
(2019),
S. 75
- 82.
C. Slouka, D. Wurm, G. Brunauer, A. Welzl-Wachter, O. Spadiut, J. Fleig, C. Herwig:
"A Novel Application for Low Frequency Electrochemical Impedance Spectroscopy as an Online Process Monitoring Tool for Viable Cell Concentrations";
Sensors,
16
(2016),
12 S.
D. Solle, B. Hitzmann, C. Herwig, M. Pereira Remelhe, S. Ulonska, L. Wuerth, A. Prata, T. Steckenreiter:
"Between the Poles of Data-Driven and Mechanistic Modeling for Process Operation";
Chemie Ingenieur Technik,
89
(2017),
5;
S. 542
- 561.
O. Spadiut, S. Capone, F. Krainer, A. Glieder, C. Herwig:
"Microbials for the production of monoclonal antibodies and antibody fragments";
Trends in Biotechnology,
32
(2014),
1;
S. 54
- 60.
O. Spadiut, C. Dietzsch, A. Posch, C. Herwig:
"Evaluating online sampling probes for substrate concentration and protein production by a Design of Experiments screening approach";
Engineering in Life Sciences,
12
(2012),
5;
S. 507
- 513.
O. Spadiut, C. Herwig:
"Dynamics in bioprocess development for Pichia pastoris";
Bioengineered,
5
(2014),
6;
S. 1
- 4.
O. Spadiut, C. Herwig:
"Mikroben zur Herstellung monoklonaler Antikörper und Antikörperfragmente";
BIOspektrum,
21
(2015),
3;
S. 281
- 283.
O. Spadiut, C. Herwig:
"Production and purification of the multifunctional enzyme horseradish peroxidase";
Pharmaceutical Bioprocessing,
1
(2013),
3;
S. 283
- 295.
O. Spadiut, S. Rittmann, C. Dietzsch, C. Herwig:
"Dynamic process conditions in bioprocess development";
Engineering in Life Sciences,
13
(2013),
S. 88
- 101.
O. Spadiut, L. Rossetti, C. Dietzsch, C. Herwig:
"Purification of a recombinant plant peroxidase produced in Pichia pastoris by a simple 2-step strategy";
Protein Expression and Purification,
86
(2012),
S. 89
- 97.
O. Spadiut, D. Zalai, C. Dietzsch, C. Herwig:
"Quantitative comparison of dynamic physiological feeding profiles for recombinant protein production with Pichia pastoris";
Bioprocess and Biosystems Engineering,
37
(2014),
6;
S. 1163
- 1172.
V. Steinwandter, D. Borchert, C. Herwig:
"Data science tools and applications on the way to Pharma 4.0";
Drug Discovery Today,
24
(2019),
9;
S. 1795
- 1805.
V. Steinwandter, M. Sismis, P. Sagmeister, U. Bodenhofer, C. Herwig:
"Multivariate analytics of chromatographic data: Visual computing based on moving window factor models";
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,
1092
(2018),
S. 179
- 190.
V. Steinwandter, T. Zahel, P. Sagmeister, C. Herwig:
"Propagation of measurement accuracy to biomass soft-sensor estimation and control quality";
Analytical and Bioanalytical Chemistry,
409
(2017),
S. 693
- 706.
C. Taylor, L. Marschall, M. Kunzelmann, M. Richter, F. Rudolph, J. Vajda, B. Presser, T. Zahel, J. Studts, C. Herwig:
"Integrated Process Model Applications Linking Bioprocess Development to Quality by Design Milestones";
Bioengineering,
8
(2021),
156;
16 S.
E. Ullmann, T. Tan, T. Gundinger, C. Herwig, C. Divne, O. Spadiut:
"A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis";
Bioscience Reports,
34
(2014),
S. 893
- 904.
S. Ulonska, P. Kroll, J. Fricke, C. Clemens, R. Voges, M. Müller, C. Herwig:
"Workflow for Target-Oriented Parametrization of an Enhanced Mechanistic Cell Culture Model";
Biotechnology Journal,
13
(2018),
4.
S. Ulonska, D. Waldschitz, J. Kager, C. Herwig:
"Model predictive control in comparison to elemental balance control in an E. coli fed-batch";
Chemical Engineering Science,
191
(2018),
S. 459
- 467.
C. Vees, L. Veiter, F. Sax, C. Herwig, S. Pflügl:
"A robust flow cytometry-based biomass monitoring tool enables rapid at-line characterization of S. cerevisiae physiology during continuous bioprocessing of spent sulfite liquor";
Analytical and Bioanalytical Chemistry,
412
(2020),
S. 2137
- 2149.
L. Veiter, C. Herwig:
"The filamentous fungus Penicillium chrysogenum analysed via flow cytometry-a fast and statistically sound insight into morphology and viability";
Applied Microbiology and Biotechnology,
103
(2019),
16;
S. 6725
- 6735.
L. Veiter, J. Kager, C. Herwig:
"Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed‑batch cultivations through morphological and physiological control";
Microbial Cell Factories,
19
(2020),
14 S.
L. Veiter, M. Kubicek, H. Hutter, E. Pittenauer, C. Herwig, C. Slouka:
"Study of metabolism and identification of productive regions in filamentous fungi via spatially resolved time-of-flight secondary ion mass spectrometry";
Analytical and Bioanalytical Chemistry,
411
(2019),
S. 1
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Zusätzliche Informationen
L. Veiter, V. Rajamanickam, C. Herwig:
"The filamentous fungal pellet-relationship between morphology and productivity";
Applied Microbiology and Biotechnology,
102
(2018),
7;
S. 2997
- 3006.
P. Wechselberger, C. Herwig:
"Model-Based Analysis on the Relationship of Signal Quality to Real-Time Extraction of Information in Bioprocesses";
Biotechnology Progress,
28
(2012),
1;
S. 265
- 275.
P. Wechselberger, P. Sagmeister, H. Engelking, T. Schmidt, J. Wenger, C. Herwig:
"Efficient feeding profile optimization for recombinant protein production using physiological information";
Bioprocess and Biosystems Engineering,
35
(2012),
S. 1637
- 1649.
P. Wechselberger, P. Sagmeister, C. Herwig:
"Model-Based Analysis on the Extractability of Information from Data in Dynamic Fed-Batch Experiments";
Biotechnology Progress,
29
(2013),
1;
S. 285
- 296.
P. Wechselberger, P. Sagmeister, C. Herwig:
"Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes";
Bioprocess and Biosystems Engineering,
36
(2013),
9;
S. 1205
- 1218.
P. Wechselberger, A. Seifert, C. Herwig:
"PAT method to gather bioprocess parameters in real-time using simple input variables and first principle relationships";
Chemical Engineering Science,
65
(2010),
S. 5734
- 5746.
M. Weissgram, J. Gstöttner, B. Lorantfy, R. Tenhaken, C. Herwig, H.K. Weber:
"Generation of PHB from Spent Sulfite Liquor Using Halophilic Microorganisms";
Microorganisms,
3
(2015),
S. 268
- 289.
M. Weissgram, C. Herwig, H.K. Weber:
"Biotechnological Generation of Value Added Products from Spent Pulping Liquors: Assessing the Potential of Extremophiles";
Journal of Bioprocessing & Biotechniques,
5
(2015),
14 S.
M. Weissgram, T. Ters, H.K. Weber, C. Herwig:
"Investigating the potential of thermophilic species for ethanol production from industrial spent sulfite Iiquor";
AIMS Energy,
3
(2015),
4;
S. 592
- 611.
K. Wieland, J. Kuligowski, D. Ehgartner, G. Ramer, C. Koch, J. Ofner, C. Herwig, B. Lendl:
"Toward a Noninvasive, Label-Free Screening Method for Determining Spore Inoculum Quality of Penicillium chrysogenum Using Raman Spectroscopy";
Applied Spectroscopy,
71
(2017),
12;
S. 2661
- 2669.
Zusätzliche Informationen
D. Wurm, J. Hausjell, S. Ulonska, C. Herwig, O. Spadiut:
"Mechanistic platform knowledge of concomitant sugar uptake in Escherichia coli BL21(DE3) strains";
Scientific Reports,
7
(2017),
45072;
11 S.
D. Wurm, L. Marschall, P. Sagmeister, C. Herwig, O. Spadiut:
"Simple monitoring of cell leakiness and viability in Escherichia coli bioprocesses-A case study";
Engineering in Life Sciences,
17
(2017),
6;
S. 598
- 604.
D. Wurm, J. Quehenberger, J. Mildner, B. Eggenreich, C. Slouka, A. Schwaighofer, K. Wieland, B. Lendl, V. Rajamanickam, C. Herwig, O. Spadiut:
"Teaching an old pET new tricks: tuning of inclusion body formation and properties by a mixed feed system in E. coli";
Applied Microbiology and Biotechnology,
102
(2018),
S. 667
- 676.
Zusätzliche Informationen
D. Wurm, C. Slouka, T. Bosilj, C. Herwig, O. Spadiut:
"How to trigger periplasmic release in recombinant Escherichia coli: A comparative analysis";
Engineering in Life Sciences,
17
(2017),
2;
S. 215
- 222.
D. Wurm, L. Veiter, S. Ulonska, B. Eggenreich, C. Herwig, O. Spadiut:
"The E. coli pET expression system revisited - mechanistic correlation between glucose and lactose uptake";
Applied Microbiology and Biotechnology,
100
(2016),
S. 8721
- 8729.
T. Zahel, S. Hauer, E. Mueller, P. Murphy, S. Abad, E. Vasilieva, D. Maurer, C. Brocard, D. Reinisch, P. Sagmeister, C. Herwig:
"Integrated Process Modeling-A Process Validation Life Cycle Companion";
Bioengineering,
4
(2017),
4;
14 S.
T. Zahel, L. Marschall, S. Abad, E. Vasilieva, D. Maurer, E. Mueller, P. Murphy, T. Natschläger, C. Brocard, D. Reinisch, P. Sagmeister, C. Herwig:
"Workflow for Criticality Assessment Applied in Biopharmaceutical Process Validation Stage 1";
Bioengineering,
4
(2017),
4;
14 S.
T. Zahel, P. Sagmeister, S. Suchocki, C. Herwig:
"Accurate Information from Fermentation Processes - Optimal Rate Calculation by Dynamic Window Adaptation";
Chemie Ingenieur Technik,
88
(2016),
6;
S. 798
- 808.
D. Zalai, C. Dietzsch, C. Herwig:
"Risk-based Process Development of Biosimilars as Part of the Quality by Design Paradigm";
PDA Journal of pharmaceutical Science and Technology,
67
(2013),
6;
S. 569
- 580.
D. Zalai, C. Dietzsch, C. Herwig, O. Spadiut:
"A Dynamic Fed Batch Strategy for a Pichia Pastoris Mixed feed System to Increase Process Understanding";
Biotechnology Progress,
28
(2012),
3;
S. 878
- 886.
D. Zalai, A. Golabgir, P. Wechselberger, A. Putics, C. Herwig:
"Advanced Development Strategies for Biopharmaceutical Cell Culture Processes";
Current Pharmaceutical Biotechnology,
16
(2015),
11;
S. 983
- 1001.
D. Zalai, H. Hever, K. Lovasz, D. Molnar, P. Wechselberger, A. Hofer, L. Parta, A. Putics, C. Herwig:
"A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cells";
Applied Microbiology and Biotechnology,
100
(2016),
S. 7011
- 7024.
D. Zalai, K. Koczka, L. Parta, P. Wechselberger, T. Klein, C. Herwig:
"Combining Mechanistic and Data-Driven Approaches to Gain Process Knowledge on the Control of the Metabolic Shift to Lactate Uptake in a Fed-Batch CHO Process";
Biotechnology Progress,
31
(2015),
6;
S. 1657
- 1668.
D. Zalai, J. Kopp, B. Kozma, M. Küchler, C. Herwig, J. Kager:
"Microbial technologies for biotherapeutics production: Key tools for advanced biopharmaceutical process development and control";
Drug Discovery Today: Technologies,
38
(2020),
S. 9
- 24.
R. Zimmerleiter, J. Kager, R. Nikzad-Langerodi, V. Berezhinskiy, F. Westad, C. Herwig, M. Brandstetter:
"Probeless non-invasive near-infrared spectroscopic bioprocess monitoring using microspectrometer technology";
Analytical and Bioanalytical Chemistry,
412
(2020),
S. 2103
- 2109.
K. Zojer, C. Herwig:
"Zwischen Wirtschaft und Wissenschaft";
ChemieReport.at,
4
(2008),
8;
S. 42
- 43.
Editorials in wiss. Zeitschriften
C. Herwig:
"Applied basic science in process analytics and control technology";
Analytical and Bioanalytical Chemistry,
412
(2020),
S. 2025
- 2026.
Buchbeiträge
T. Barz, J. Kager, C. Herwig, P. Neubauer, M. Cruz Bournazou, F. Galvanin:
"Characterization of reactions and growth in automated continuous flow and bioreactor platforms-From linear DoE to model-based approaches";
in: "Simulation and Optimization in Process Engineering",
M. Bortz, N. Asprion (Hrg.);
Elsevier Inc.,
Amsterdam, NL,
2022,
ISBN: 978-0-323-85043-8,
S. 273
- 319.
S. Daume, J. Kager, C. Herwig:
"Time Resolved Sensitivity & Identifiability Analysis for Directed Parametrization of Highly Dynamic Models";
in: "Computer Aided Chemical Engineering, 29th European Symposium on Computer Aided Process Engineering",
46;
Elsevier,
2019,
ISBN: 978-0-12-818634-3,
S. 1111
- 1116.
S. Daume, S. Kofler, J. Kager, P. Kroll, C. Herwig:
"Generic Workflow for the Setup of Mechanistic Process Models";
in: "Animal Cell Biotechnology",
Springer Science + Business Media,
2020,
ISBN: 978-1-0716-0190-7,
S. 189
- 211.
A. Golabgir, D. Ehgartner, L. Neutsch, A. Posch, P. Sagmeister, C. Herwig:
"Imaging Flow Cytometry and High-Throughput Microscopy for Automated Macroscopic Morphological Analysis of Filamentous Fungi";
in: "Genetic Transformation Systems in Fungi, Vol. 2",
M. van den Berg, K. Maruthachalam (Hrg.);
Springer International Publishing,
2015,
ISBN: 978-3-319-10503-1,
S. 201
- 210.
C. Herwig:
"Christain Doppler-Labor für Mechanistische und Physiologische Methoden für leistungsfähigere Bioprozesse";
in: "Die Fakultät für Technische Chemie",
Band 10;
H. Danninger, P. Weinberger (Hrg.);
Böhlau Verlag,
Wien-Köln-Weimar,
2015,
ISBN: 978-3-205-20117-5,
S. 75
- 78.
C. Herwig:
"Preface to "Hybrid Modelling and Multi-Parametric Control of Bioprocesses"";
in: "Hybrid Modelling and Multi- Parametric Control of Bioprocesses",
C. Herwig (Hrg.);
MDPI Ag, Basel, Switzerland,
2018,
ISBN: 978-3-03842-746-9,
S. vii.
C. Herwig:
"The Analytical Challenge in QbD - From Data to Information and to Knowledge - From (Bioprocess) Development to Manufacturing";
in: "Quality by Design - Putting Theory into Practice",
PDA/DHI Technical Books,
2011,
ISBN: 978-1933722481,
S. 163
- 194.
C. Herwig, R. Pörtner, J. Möller:
"Preface";
in: "Digital Twins - Applications to the Design and Optimization of Bioprocesses",
177;
C. Herwig, R. Pörtner, J. Möller (Hrg.);
Springer Nature Switzerland AG 2021,
Cham, Schweiz,
2021,
ISBN: 978-3-030-71655-4,
S. v
- vi.
C. Herwig, C. Slouka, P. Neubauer, F. Delvigne:
"Editorial: Continuous Biomanufacturing in Microbial Systems";
in: "Continuous Biomanufacturing in Microbial Systems",
Frontiers,
Lausanne, Schweiz,
2021,
ISBN: 978-2-88971-120-8,
3 S.
J. Kager, V. Berezhinskiy, R. Zimmerleitner, M. Brandstetter, C. Herwig:
"Extension of a Particle Filter for Bioprocess State Estimation using Invasive and Non-Invasive IR Measurements";
in: "Computer Aided Chemical Engineering, 29th European Symposium on Computer Aided Process Engineering",
46;
Elsevier,
2019,
ISBN: 978-0-12-818634-3,
S. 1417
- 1422.
S. Kittler, J. Kopp, V. Patrick Gwen, O. Spadiut, F. Delvigne, C. Herwig, C. Slouka:
"The Lazarus Escherichia coli Effect: Recovery of Productivity on Glycerol/Lactose Mixed Feed in Continuous Biomanufacturing";
in: "Continuous Biomanufacturing in Microbial Systems",
Frontiers,
Lausanne, Schweiz,
2021,
ISBN: 978-2-88971-120-8,
11 S.
V. Rajamanickam, P. Sagmeister, O. Spadiut, C. Herwig:
"Impurity Monitoring as Novel PAT Tool for Continuous Biopharmaceutical Processes";
in: "Continuous Bioprocessing - Industry Best Practices",
Repligen,
2018,
ISBN: 978-92-79-15227-6,
S. 89
- 101.
P. Sagmeister, M. Jazini, J. Klein, C. Herwig:
"Bacterial Suspension Cultures";
in: "Industrial Scale Suspension Culture of Living Cells",
Wiley - Blackwell,
2014,
ISBN: 978-3-527-33547-3,
S. 41
- 94.
P. Sinner, S. Daume, C. Herwig, J. Kager:
"Usage of Digital Twins Along a Typical Process Development Cycle";
in: "Digital Twins - Tools and Concepts for Smart Biomanufacturing",
C. Herwig, R. Pörtner, J. Möller (Hrg.);
Springer International Publishing,
2021,
ISBN: 978-3-030-71659-2.
P. Sinner, C. Herwig, J. Kager:
"Time Scale Analysis and Optimization of a Continuous Microbial Bioprocess";
in: "Computer Aided Chemical Engineering, 30th European Symposium on Computer Aided Process Engineering",
48;
S. Pierucci, F. Manenti, G. Bozzano, D. Manca (Hrg.);
Elsevier B.V.,
2020,
ISBN: 978-0-1282-3377-1,
S. 1603
- 1608.
O. Spadiut, C. Dietzsch, C. Herwig:
"Determination of a Dynamic Feeding Strategy for Recombinant Pichia pastoris Strains";
in: "Yeast Metabolic Engineering; Methods in Molecular Biology Vol. 1152",
V. Mapelli (Hrg.);
Springer-Verlag,
2014,
ISBN: 978-1-4939-0563-8,
S. 185
- 194.
I. Stelzer, J. Kager, C. Herwig:
"Comparison of Particle Filter and Extended Kalman Filter Algorithms for Monitoring of Bioprocesses";
in: "Proceedings of the 27th European Symposium on Computer Aided Process Engineering - ESCAPE 27",
40;
A. Espuña, M. Graells, L. Puigjaner (Hrg.);
Elsevier B.V.,
2017,
ISBN: 978-0-444-63965-3,
S. 1483
- 1488.
S. Ulonska, J. Kager, C. Herwig:
"Automatic controller failure detection with application in model based control of an E. coli fed-batch";
in: "Computer-Aided Chemical Engineering, Vol. 43 - 28th European Symposium on Computer Aided Process Engineering Part A",
A. Friedl, J. Klemes, S. Radl, P. Varbanov, T. Wallek (Hrg.);
Elsevier B.V.,
2018,
ISBN: 978-0-444-64237-0,
S. 1673
- 1678.
D. Wurm, C. Herwig, O. Spadiut:
"How to Determine lnterdependencies of Glucose and Lactose Uptake Rates for Heterologous Protein Production with E. Coli";
in: "Heterologous Gene Expression in E. coli",
N. Burgess-Brown (Hrg.);
Humana Press,
New York, USA,
2017,
ISBN: 978-1-4939-6885-5,
S. 397
- 408.
M. Zinn, T. Egli, C. Herwig, A. Narang:
"Editorial: Recent Advances in Continuous Cultivation";
in: "Recent Advances in Continuous Cultivation",
M. Zinn, T. Egli, C. Herwig, A. Narang (Hrg.);
Frontiers,
Lausanne, Schweiz,
2021,
ISBN: 978-2-88966-649-2,
3 S.
Vorträge und Posterpräsentationen (mit Tagungsband-Eintrag)
S. Bernacchi, C. Herwig:
"Application of amodular and interdisciplinary approach to the development of a biologicalmethane production (BMP) process";
Poster: REGATEC 2015 - 2nd International Conference on Renewable Energy Gas Technology,
Barcelona, Spanien;
07.05.2015
- 08.05.2015; in: "Conference Proceedings",
(2015),
ISBN: 978-91-981149-1-1;
S. 103
- 104.
G. Bonifert, L. Folkes, C. Gmeiner, C. Herwig, G. Dachs, O. Spadiut:
"Recombinant horseradish peroxidase variants for targeted cancer treatment";
Poster: Pichia 2016 Conference,
Antalya, Türkei;
03.04.2016
- 06.04.2016; in: "Abstract Book",
(2016),
S. 50.
M. Brunner, J. Fricke, C. Herwig:
"lnvestigation of scale-up effects on mammalian cell culture process performance and critical quality attributes";
Vortrag: 4th BioProScale Symposium,
Berlin, Deutschland;
06.04.2016
- 08.04.2016; in: "Abstract Booklet",
(2016),
S. 9.
M. Brunner, J. Fricke, C. Herwig:
"The Effect Of Large-scale Heterogeneities On Mammalian Cell Culture Process Performance And Critical Quality Attributes";
Poster: European Symposium on Biochemical Engineering Sciences 2016,
Dublin, Irland;
11.09.2016
- 14.09.2016; in: "http://www.esbes2016.org/",
(2016),
Paper-Nr. 3333283,
1 S.
S. Capone, J. Horvat, C. Herwig, O. Spadiut:
"Development of a mixed feed strategy for a recombinant Pichia pastoris strain producing with a de-repression promoter";
Poster: Pichia 2016 Conference,
Antalya, Türkei;
03.04.2016
- 06.04.2016; in: "Abstract Book",
(2016),
S. 51.
S. Clara, M. Heinisch, A. Golabgir, C. Herwig, B. Jakoby:
"lnline Viskositäts-Sensor für Bioprozess Monitoring";
Poster: 13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion,
Esslingen, Deutschland;
21.11.2017
- 22.11.2017; in: "Programm",
(2017),
S. 56
- 57.
C. Dietzsch, C. Herwig:
"Bioprozessoptimierung eines rekombinanten Pichia pastoris-Expressionsstammes";
Vortrag: ProcessNet Jahrestagung 2010,
Aachen, Deutschland;
21.09.2010
- 23.09.2010; in: "Chemie Ingenieur Technik",
Chemie Ingenieur Technik / Wiley-VCH,
82 / 9
(2010),
ISSN: 0009-286x;
S. 1494
- 1495.
C. Dietzsch, C. Herwig:
"Determination of protein production related parameters in a recombinant Pichia Pastoris MutS expression strain";
Vortrag: ESBES - 8th European Symposium on Biochemical Engineering Science,
Bologna, Italien;
05.09.2010
- 08.09.2010; in: "Book of Abstracts",
(2010),
S. 155.
C. Dietzsch, C. Hutterer, A. Camattari, R. Gudiminchi, C. Herwig:
"Recombinant expression of Cytochromes P450 - a step towards whole cell bioconversion in Pichia pastoris";
Vortrag: 9th European Congress of Chemical Engineering / 2nd European Congress of Applied Biotechnology,
Den Haag, Niederlande;
21.04.2013
- 25.04.2013; in: "www.ecce2013.eu",
(2013),
1 S.
C. Dietzsch, D. Rial, C. Herwig:
"Method establishment for determination of protein expression related parameters";
Poster: International Graz Congress for Pharmaceutical Engineering,
Graz;
17.09.2009
- 18.09.2009; in: "International Graz Congress for Pharmaceutical Engineering - Book of Abstracts",
(2009).
C. Dietzsch, O. Spadiut, C. Herwig:
"A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris";
Poster: RPP 6 Conference 2011 - A comparative view on host physiology,
Wien;
16.02.2011
- 19.02.2011; in: "Abstract Book",
(2011),
S. 72.
C. Dietzsch, O. Spadiut, D. Zalai, C. Herwig:
"A fast approach in bioprocess development for recombinant protein expression in Pichia pastoris";
Poster: 4th ÖGMBT Annual Meeting,
Graz;
17.09.2012
- 19.09.2012; in: "Abstract Book 2012",
(2012),
S. 94
- 95.
C. Dietzsch, O. Spadiut, D. Zalai, C. Herwig:
"A fast approach in bioprocess development for recombinant protein expression in Pichia pastoris";
Poster: Biochemical Engineering Course,
Supetar, Insel Brac, Kroatien;
02.09.2012
- 08.09.2012; in: "Poster Abstracts 2012",
(2012),
S. 14.
C. Dietzsch, O. Spadiut, D. Zalai, C. Herwig:
"A fast approach in bioprocess development for recombinant protein expression in Pichia pastoris ( Effiziente Bioprozessentwicklung für rekombinante Proteinexpression in Pichia pastoris)";
Poster: ProcessNet-Jahrestagung und 30. DECHEMA-Jahrestagung der Biotechnologen,
Karlsruhe, Deutschland;
10.09.2012
- 13.09.2012; in: "Chemie Ingenieur Technik",
Vol. 84 / Nr. 8
(2012),
ISSN: 0009-286x;
S. 1341.
C. Dietzsch, O. Spadiut, D. Zalai, C. Herwig:
"From Strain to Product : A fast approach in bioprocess development for recombinant protein expression in Pichia pastoris";
Poster: Pichia 2012 Conference,
Alpbach;
29.02.2012
- 03.03.2012; in: "Abstract Book",
(2012),
S. 69
- 70.
B. Eggenreich, V. Rajamanickam, O. Spadiut, C. Herwig:
"A Novel PAT Tool To Monitor The lmpurity Pattern During lnclusion Body Processing";
Poster: European Symposium on Biochemical Engineering Sciences 2016,
Dublin, Irland;
11.09.2016
- 14.09.2016; in: "http://www.esbes2016.org/",
(2016),
Paper-Nr. 3333461,
1 S.
D. Ehgartner, J. Fricke, C. Herwig:
"A PAT tool for real-time determination of spore quality in filamentaus fungi bioprocesses";
Poster: 4th BioProScale Symposium,
Berlin, Deutschland;
06.04.2016
- 08.04.2016; in: "Abstract Booklet",
(2016),
S. 30.
D. Ehgartner, J. Fricke, C. Herwig:
"At-line monitaring of spore quality, spore swelling and spore germination in filamentaus fungi";
Poster: 11. Kolloquium Arbeitskreis Prozessanalytik der DECHEMA und der GDCh-Fachgruppe Analytische Chemie,
Wien;
30.11.2015
- 02.12.2015; in: "Tagungsband",
(2015),
S. 86.
D. Ehgartner, J. Fricke, C. Herwig:
"At-line monitoring of spore inoculum quality and spore germination in filamentous fungi";
Poster: PYFF6 - 6th Conference on Physiology of Yeasts and Filamentous Fungi,
Lissabon, Portugal;
11.07.2016
- 14.07.2016; in: "Programme and Abstract Book",
(2016),
ISBN: 978-989-20-6736-0;
S. 141.
D. Ehgartner, A. Schröder, J. Fricke, C. Herwig:
"An at-line PAT tool determining spore quality in filamentous bioprocesses";
Poster: IBF - Industrial Biotechnology Forum 2016,
München, Deutschland;
14.03.2016
- 15.03.2016; in: "http://ibf-conference.org/",
(2016),
Paper-Nr. 38,
1 S.
A. Erian, M. Gibisch, C. Herwig, S. Pflügl:
"Microbial production of 2,3-butanediol: a comparison between Escherichia coli and Vibrio natriegens";
Vortrag: 10th ÖGMBT Annual Meeting,
Vienna;
17.09.2018
- 20.09.2018; in: "Abstract Book",
(2018),
S. 160.
J. Fricke, S. Hauer, D. Ehgartner, P. Kroll, I. Stelzer, M. Hofinger, C. Herwig:
"An offline model-based approach for forecasting appropriate feeding strategies in Fungi cultivations";
Poster: 11. Kolloquium Arbeitskreis Prozessanalytik der DECHEMA und der GDCh-Fachgruppe Analytische Chemie,
Wien;
30.11.2015
- 02.12.2015; in: "Tagungsband",
(2015),
S. 84
- 85.
F. Gattermayr, V. Leitner, C. Herwig:
"Butanol Production from Volatile Feedstocks, Development of an Optimized Bioprocess";
Poster: Workshop on ABE Production and CO2/H2 Fermentation,
Wien;
10.11.2016
- 11.11.2016; in: "Book of Abstracts",
(2016),
S. 17
- 18.
C. Gmeiner, D. Maresch, F. Altmann, C. Herwig, O. Spadiut:
"Development of a fed-batch process for a Pichia pastoris OCH1 knock-out strain";
Poster: 6th ÖGMBT Annual Meeting - Life Sciences meet Entrepreneurship,
Wien;
15.09.2014
- 18.09.2014; in: "Abstract Book",
(2014),
S. 201.
C. Gmeiner, A. Saadati, D. Maresch, S. Krasteva, M. Frank, F. Altmann, C. Herwig, O. Spadiut:
"Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase";
Vortrag: Pichia 2016 Conference,
Antalya, Türkei (eingeladen);
03.04.2016
- 06.04.2016; in: "Abstract Book",
(2016),
S. 27.
J. Haas, O. Garcia-Aponte, A. Golabgir, B. Vallejo-Diaz, A. Rathore, C. Herwig:
"Der Brückenschlag des Wissensmanagements: Akademische Methoden für industrielle Geschäftsprozesse in Biopharma";
Vortrag: 11. Kolloquium Arbeitskreis Prozessanalytik der DECHEMA und der GDCh-Fachgruppe Analytische Chemie,
Wien (eingeladen);
30.11.2015
- 02.12.2015; in: "Tagungsband",
(2015),
S. 35
- 36.
T. Hardiman, M. Hofinger, P. Ettinger, G. Kornfeld, M. Weiner, P. Wechselberger, J. Buchholz, W. Riethorst, W. Skibar, J. Kager, I. Stelzer, A. Golabgir, D. Ehgartner, C. Herwig:
"Implementierung einer Softsenser-basierten Regelung eines großtechnischen Fermentationsprozesses";
Vortrag: 13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion,
Esslingen, Deutschland;
21.11.2017
- 22.11.2017; in: "Programm",
(2017),
S. 50.
M. Helmel, M. Marchetti-Deschmann, A. Posch, C. Herwig, G. Allmaier:
"Differentiation of growth stages of Penicillium chrysogenum by intact cell mass spectrometry";
Poster: 4th Summer School on Mass Spectrometry in Biotechnology and Medicine,
Dubrovnik, Croatia;
04.07.2010
- 10.07.2010; in: "4th Summer School MSBM - Book of Abstracts",
J. Souady (Hrg.);
(2010),
S. 75.
M. Helmel, M. Marchetti-Deschmann, A. Posch, C. Herwig, G. Allmaier:
"Monitoring the fermentation process of Penicillium chrogenum by means of intact cell mass spectrometry and proteomics approach";
Vortrag: 7. ASAC JunaganalytikerInnen Forum,
Linz;
25.09.2011
- 26.09.2011; in: "7. ASAC JunganalytikerInnen Forum Book of Abstracts",
(2011),
S. 26.
M. Helmel, M. Marchetti-Deschmann, A. Posch, C. Herwig, G. Allmaier:
"Monitoring the fermentation process of Penicillium chrysogenum by intact cell mass spectrometry";
Poster: 2011 Einsteins in the City,
New York, USA;
14.04.2011
- 15.04.2011; in: "Abstract Booklet",
(2011).
M. Helmel, M. Marchetti-Deschmann, M. Raus, A. Posch, M. Sebela, C. Herwig, G. Allmaier:
"Intact cell mass spectrometry as a monitoring tool for filamentous fungi fermentation";
Poster: 31th Informal Meeting on Mass Spectrometry (IMMS2013),
Palermo, Italien;
05.05.2013
- 08.05.2013; in: "Book of Abstract",
(2013),
ISBN: 978-88-907388-2-1;
188 S.
C. Herwig:
"A Novel PAT Tool for Horizontal Impurity Monitoring";
Vortrag: 7th Monolith Summer School and Symposium,
Portoroz, Slowenien (eingeladen);
27.05.2016
- 01.06.2016; in: "Abstract Book",
(2016),
S. 15.
C. Herwig:
"An integrated QbD Approach for scientifically based comprehensive bioprocess development";
Vortrag: International Graz Congress for Pharmaceutical Engineering,
Graz;
17.09.2009
- 18.09.2009; in: "International Graz Congress for Pharmaceutical Engineering - Book of Abstracts",
(2009),
S. 21.
C. Herwig:
"Biopharmaceuticals 2100 - The future is today";
Vortrag: Exyte Life Sciences Seminar 2019,
Basel, Schweiz (eingeladen);
24.09.2019; in: "Abstracts",
(2019),
1 S.
C. Herwig:
"Control strategies for integrated continuous bioprocessing";
Vortrag: lntegrated Continuous Biomanufacturing IV,
Brewster, MA, USA (eingeladen);
06.10.2019
- 10.10.2019; in: "Abstracts",
(2019),
1 S.
C. Herwig:
"Data science and PAT tools for the bioprocess life cycle";
Vortrag: BioTech 2019,
Zürich, Schweiz (eingeladen);
02.07.2019
- 04.07.2019; in: "Abstracts",
(2019),
S. 34.
C. Herwig:
"Data Science or PAT as Control Strategies for Continuous Biomanufacturing";
Vortrag: Bioprocessing Summit Europe 2020 (Online Conference),
Barcelona, Spanien (eingeladen);
21.07.2020
- 23.07.2020; in: "Abstracts",
(2020),
1 S.
C. Herwig:
"Designing stability points using cryoprocessing: Methodological approaches to operate economic viable multiproduct facilities";
Vortrag: IIR Workshop 2013 on Cryoprocessing of Biopharmaceuticals and Biomaterials,
Dresden, Deutschland;
04.09.2013
- 05.09.2013; in: "Book of Abstracts",
(2013),
ISBN: 978-2-36215-001-2;
S. 23.
C. Herwig:
"Digital Twin-Based Design and Optimization for Cell Culture Processes";
Vortrag: The 12th Bioprocessing Summit (Online Conference),
Needham, MA, USA (eingeladen);
24.08.2020
- 28.08.2020; in: "Abstracts",
(2020),
1 S.
C. Herwig:
"Digital Twins for Process Robustness and Control Strategies";
Vortrag: Bioprocessing Summit Europe 2019,
Lissabon, Portugal (eingeladen);
19.03.2019
- 21.03.2019; in: "Abstracts",
(2019),
1 S.
C. Herwig:
"Effiziente Bioprozess-Entwicklung durch Echtzeit Auswertung und Stress-Analyse - ein integrierter QbD Ansatz";
Vortrag: Arbeitskreis Prozessanalytik - 5.Kolloquium,
Göttingen, Deutschland;
30.11.2009
- 01.12.2009; in: "Arbeitskreis Prozessanalytik - 5.Kolloquium - Tagungsband",
(2009),
S. 20
- 21.
C. Herwig:
"Effiziente Bioprozess-Identifikation durch Echtzeit Auswertung und Stress-Analyse";
Vortrag: 23.VH Hefetagung,
Wien;
26.04.2010
- 27.04.2010; in: "Proceedings of the 23rd VH-Yeast Conference",
(2010),
S. 39
- 50.
C. Herwig:
"Elucidating the potential of bio-processes on industrial waste streams";
Hauptvortrag: International Conference on Advances in Biotechnology,
Dubai, VAE (eingeladen);
10.07.2017
- 12.07.2017; in: "Conference Proceedings",
(2017),
S. 26.
C. Herwig:
"Generic Methods for Development of Bioprocesses Based on Quality-by-design (QbD) Principles";
Vortrag: ibio BIT's 4th Annual World Congress of Industrial Biotechnology-2011,
Dalian, China;
25.04.2011
- 30.04.2011; in: "ibio BIT's 4th Annual World Congress of Industrial Biotechnology-2011",
(2011),
S. 169.
C. Herwig:
"Generic methods for scale up of bioprocesses based on Quality-by-Design (QbD) principles";
Vortrag: 2nd BioProScale Symposium - Inhomogeneities in large-scale bioprocesses,
Berlin, Deutschland;
14.03.2012
- 16.03.2012; in: "www.ifgb.de",
(2012),
1 S.
C. Herwig:
"Hybrid modelling and multi-parametric control of bioprocesses";
Hauptvortrag: 4th BioProScale Symposium,
Berlin, Deutschland (eingeladen);
06.04.2016
- 08.04.2016; in: "Abstract Booklet",
(2016),
S. 7.
C. Herwig:
"Integrated bioprocess data management - An integrated QbD Approach for scientifically based bioprocess development";
Vortrag: ESBES - 8th European Symposium on Biochemical Engineering Science,
Bologna, Italien;
05.09.2010
- 08.09.2010; in: "Book of Abstracts",
(2010),
S. 179.
C. Herwig:
"Integrated Bioprocess Development of Bioethanol and Biomethane Production Aiming at a Co2 Neutral Process";
Vortrag: BIT's 1st Annual World Congress of Bioenergy-2011,
Dalian, China;
25.04.2011
- 30.04.2011; in: "BIT's 1st Annual World Congress of Bioenergy-2011",
(2011),
S. 262.
C. Herwig:
"Integrated Digital Twins for Intensified Bioprocessing Life Cycling";
Vortrag: World Biopharm Forum 2019,
Oxford, UK (eingeladen);
26.06.2019
- 28.06.2019; in: "Abstracts",
(2019),
S. 20.
C. Herwig:
"Integrating digital twins for robust control strategies and real time release";
Hauptvortrag: Intelligent Bioprocessing Summit,
Amsterdam, Niederlande (eingeladen);
11.11.2021
- 12.11.2021; in: "Abstracts",
(2021),
1 S.
C. Herwig:
"Knowledge Transfer Workflows to facilitate Quality by Design to enter into practice";
Vortrag: WCCE10 - 10th World Congress of Chemical Engineering,
Barcelona, Spanien (eingeladen);
01.10.2017
- 05.10.2017; in: "http://www.wcce10.org/index.php/program/st-program",
(2017),
1 S.
C. Herwig:
"Lösungen zur Prozessintensivierung durch Hybridprozesse mit extremophilen Organismen";
Vortrag: 745. DECHEMA-Kolloquium - Leben am Limit - extremophile Mikroorganismen,
Frankfurt am Main, Deutschland (eingeladen);
18.02.2016; in: "Kurzfassungen",
(2016),
S. 1.
C. Herwig:
"Mechanistic Modelling for Bioprocess Monitoring and Control - Prerequisites and Benefits";
Hauptvortrag: Himmelfahrtstagung 2017 - Models for Developing and Optimising Biotech Production,
Neu-Ulm, Deutschland (eingeladen);
22.05.2017
- 24.05.2017; in: "Book of Abstracts",
(2017),
S. 37.
C. Herwig:
"Model based analysis of purification steps";
Vortrag: Bio Talk - Biological Manufacturing Excellence,
Berlin, Deutschland (eingeladen);
13.09.2021
- 16.09.2021; in: "Abstracts",
(2021),
1 S.
C. Herwig:
"Model based analysis of purification steps";
Vortrag: Biotalk US VT 2021,
Boston, USA (eingeladen);
11.10.2021
- 14.10.2021; in: "Abstracts",
(2021),
1 S.
C. Herwig:
"Model Based Control Strategies: Enabling Continuous Upstream Biomanufacturing for Antibody Production";
Vortrag: BioProcess International European Summit 2018,
Amsterdam, Niederlande (eingeladen);
23.04.2018
- 25.04.2018; in: "https://lifesciences.knect365.com/bpieurope/agenda/3#",
(2018),
1 S.
C. Herwig:
"Multi-parametric Control Of Bioprocesses Using Mechanistic Models";
Poster: European Symposium on Biochemical Engineering Sciences 2016,
Dublin, Irland;
11.09.2016
- 14.09.2016; in: "http://www.esbes2016.org/",
(2016),
Paper-Nr. 3343710,
1 S.
C. Herwig:
"Prozessstabilität durch Modelle, Data Science und PAT Tools";
Vortrag: 14. Kolloquium Prozessanalytik,
Hannover, Deutschland (eingeladen);
03.12.2018
- 05.12.2018; in: "Programm",
(2018),
S. 50.
C. Herwig:
"Real-time transformation of data knowledge - preferably using soft sensors?";
Vortrag: BioTech 2011,
Wädenswil, Schweiz;
01.09.2011
- 02.09.2011; in: "Bioprocess Analytics and Sensor Technology",
(2011),
S. 28.
C. Herwig:
"Skalierbare und schnelle Prozessentwicklung - Ein integrierter methodischer Ansatz";
Vortrag: Bio Processing Days 2017,
Recklingshausen, Deutschland (eingeladen);
20.02.2017
- 22.02.2017; in: "Bio Processing Days 2017",
(2017),
S. 16.
C. Herwig:
"Smart bioprocessing using data science tools";
Vortrag: 14th Danish Conference on Biotechnology: Therapeutic Proteins,
Vejle, Dänemark (eingeladen);
28.05.2019
- 29.05.2019; in: "Abstract Book",
(2019).
C. Herwig:
"Strategies for Generation and Adaptation of Digital Twins";
Vortrag: The 12th Bioprocessing Summit (Online Conference),
Needham, MA, USA (eingeladen);
24.08.2020
- 28.08.2020; in: "Abstracts",
(2020),
1 S.
C. Herwig:
"Tuning E.coli expression platforms for targeted inclusion body quality and smooth downstream processing";
Vortrag: BioProcess International European Summit 2017,
Amsterdam, Niederlande (eingeladen);
25.04.2017
- 26.04.2017; in: "https://lifesciences.knect365.com/bpieurope/agenda/3?stream=2",
(2017),
1 S.
C. Herwig:
"Workflows for Data Science Enabled Stage 1 Validation";
Vortrag: 2018 BioMAN Spring Workshop,
Cambridge, MA, USA (eingeladen);
21.05.2018
- 22.05.2018; in: "Abstracts",
(2018).
C. Herwig:
"Workflows und Nutzen von Digital Twins";
Vortrag: BioProcessingDays 2019,
Recklingshausen, Deutschland (eingeladen);
18.02.2019
- 20.02.2019; in: "BPDs 2019",
(2019),
S. 12.
C. Herwig:
"Workflows und Nutzen von Digitalen Zwillingen und Softsensoren";
Vortrag: 14. Dresdner Sensor-Symposium,
Dresden, Deutschland (eingeladen);
02.12.2019
- 04.12.2019; in: "Abstracts",
(2019),
1 S.
C. Herwig, O. Spadiut:
"Trends for successful biopharmaceutical productions - Future challenges in process and facility design";
Hauptvortrag: 6th Monolith Summer School & Symposium,
Portoroz, Slowenien (eingeladen);
30.05.2014
- 04.06.2014; in: "Book of Abstracts",
(2014),
S. 13.
E. Herwig, M. Marchetti-Deschmann, C. Herwig, C. Wenz, A. Ruefer, G. Allmaier:
"A new approach: Combining imunoprecipitation with high sensitiuvity protein sizing on microchips for specific detection of proteins";
Poster: 30th International Symposium on the Separation of Proteins, Peptides and Polynucleotides (BEST 2010),
Bologna, Italy;
05.09.2010
- 08.09.2010; in: "ESBES - ISPPP - ISB BEST 2010 Book of Abstracts",
(2010),
S. 338.
A. Hofer, D. Kamravamanesh, C. Herwig, J. Fricke:
"Prediction of filamentous growth by CSL quality assessment using mid-infrared spectroscopy and chemometrics";
Poster: Himmelfahrtstagung 2017 - Models for Developing and Optimising Biotech Production,
Neu-Ulm, Deutschland;
22.05.2017
- 24.05.2017; in: "Book of Abstracts",
(2017),
S. 157.
A. Hofer, P. Kroll, A. Riklin, M. Barmettler, C. Herwig:
"Automated sampling and analytics to increase process understanding and process stability";
Vortrag: 14. Kolloquium Prozessanalytik,
Hannover, Deutschland (eingeladen);
03.12.2018
- 05.12.2018; in: "Programm",
(2018),
S. 46.
M. Jazini, C. Herwig:
"Effects of substrate-related stress on recombinant protein production";
Vortrag: ICPE - 5th International Congress on Pharmaceutical Engineering,
Graz;
29.09.2011
- 30.09.2011; in: "Book of Abstracts",
(2011),
S. 43.
M. Jazini, C. Herwig:
"Temperature and substrate-related stresses enhance recombinant protein production";
Vortrag: 2nd BioProScale Symposium - Inhomogeneities in large-scale bioprocesses,
Berlin, Deutschland;
14.03.2012
- 16.03.2012; in: "www.ifgb.de",
(2012),
1 S.
J. Kager, C. Herwig, V. Berezhinskiy:
"State estimation and control of bioprocesses based on mechanistic models";
Vortrag: IFPAC 2019 - 33rd International Forum and Exhibition on Process Analytical Chemistry (IFPAC) Annual Meeting,
Washington D.C., USA;
03.03.2019
- 06.03.2019; in: "Abstracts",
(2019),
1 S.
J. Kager, S. Ulonska, F. Pollesböck, C. Herwig:
"Engineer“s Playground: Interfacing Students and Bioreactors for Teaching and Research";
Vortrag: VSS 2018 - Vienna Young Scientists Symposium,
Wien;
07.06.2018
- 08.06.2018; in: "VSS 2018",
Book-of-Abstracts.com,
(2018),
ISBN: 978-3-9504017-8-3;
S. 64
- 65.
D. Kamravamanesh, T. Kovacs, I. Druzhinina, S. Pflügl, M. Lackner, C. Herwig:
"Photosynthetic Polyhydroxybutyrate Production in Cyanobacteria";
Vortrag: ESBES 2018 - European Symposium on Biochemical Engineering Sciences,
Lissabon, Portugal;
09.09.2018
- 12.09.2018; in: "Book of Abstracts",
(2018),
1 S.
C. Koch, C. Herwig, B. Lendl:
"In-line monitoring of trehalose in yeast using an ultrasound enhanced mid-IR fiber optic sensor";
Hauptvortrag: 27th Yeast Conference,
Istanbul;
14.04.2014
- 15.04.2014; in: "Proceedings of the 27th Yeast Conference",
Editor Versuchsanstalt der hefeindustrie e.V.,
(2014),
S. 177
- 188.
Zusätzliche Informationen
C. Koch, M. R. Plata Torres, S. Radel, B. Lorantfy, P. Wechselberger, C. Herwig, B. Lendl:
"In-line spectroscopy of yeast cells during fermentation using an ultrasound enhanced ATR FT-IR fibre otpic probe";
Vortrag: 9. ASAC JunganalytikerInnen Forum,
Wien;
21.06.2013
- 22.06.2013; in: "Book of Abstracts - 9. ASAC JunganalytikerInnen Forum",
(2013),
S. 39.
C. Koch, M. R. Plata Torres, P. Wechselberger, M. Brandstetter, B. Lorantfy, S. Radel, C. Herwig, B. Lendl:
"Spectroscopy of Yeast Cells During Fermentation Using an In-line Ultrasound Enhanced ATR FTIR Fiber Optic Probe";
Poster: ICAVS 7,
Kobe, Japan;
25.08.2013
- 30.08.2013; in: "Seventh International Conference on Advanced Vibrational Spectroscopy - Program - Abstracts",
(2013),
S. 284.
V. Konakovsky, T. Le, A. Yongky, R. Raju, N. Vishvanathan, C. Herwig, W. Hu:
"Bridging transcriptomics, modeling and process control in a systems approach for mammalian cell culture";
Vortrag: 11. Minisymposium Verfahrenstechnik,
Wien;
14.04.2015
- 15.04.2015; in: "Proceedings",
(2015),
ISBN: 978-3-200-04069-4;
S. 142
- 147.
J. Kopp, C. Slouka, F. Delvigne, C. Herwig:
"Continuous bioprocessing with E. coli: chances and drawbacks";
Vortrag: World Biopharm Forum 2019,
Oxford, UK (eingeladen);
26.06.2019
- 28.06.2019; in: "Abstracts",
(2019),
S. 32.
J. Kopp, C. Slouka, H. Sassi, F. Delvigne, C. Herwig:
"Population heterogeneities in long-term chemostat E. coli cultivations determined with online & at-line flow-cytometry analysis";
Poster: RPP10 Conference - A Comparative View on Host Physiology,
Kreta, Griechenland;
24.04.2019
- 27.04.2019; in: "Abstracts",
(2019),
1 S.
J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of glycerol as carbon source onto specific sugar and inducer uptake rates and inclusion body productivity in E. coli BL21 (DE3)";
Poster: 5th BioProScale Symposium,
Berlin, Deutschland;
20.03.2018
- 22.03.2018; in: "Abstract Booklet",
(2018),
S. 48.
J. Kopp, C. Slouka, S. Ulonska, J. Kager, J. Fricke, O. Spadiut, C. Herwig:
"Impact of glycerol as carbon source onto specific sugar and inducer uptake rates and inclusion body productivity in E. coli BL21(DE3)";
Vortrag: ESBES 2018 - European Symposium on Biochemical Engineering Sciences,
Lissabon, Portugal;
09.09.2018
- 12.09.2018; in: "Book of Abstracts",
(2018),
1 S.
P. Kroll, K. Eilers, C. Herwig:
"Real time estimation of the lysed cell density in mammalian cell culture";
Poster: 11. Kolloquium Arbeitskreis Prozessanalytik der DECHEMA und der GDCh-Fachgruppe Analytische Chemie,
Wien;
30.11.2015
- 02.12.2015; in: "Tagungsband",
(2015),
S. 83.
P. Kroll, C. Herwig:
"Generic workflow for the setup of substantial target-oriented mechanistic process models";
Poster: 13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion,
Esslingen, Deutschland;
21.11.2017
- 22.11.2017; in: "Programm",
(2017),
S. 82.
P. Kroll, C. Herwig:
"Generic workflow for the setup of substantial target-oriented mechanistic process models for mammalian processes";
Poster: Himmelfahrtstagung 2017 - Models for Developing and Optimising Biotech Production,
Neu-Ulm, Deutschland;
22.05.2017
- 24.05.2017; in: "Book of Abstracts",
(2017),
S. 156.
P. Kroll, C. Slouka, S. Ulonska, J. Kopp, A. Hofer, T. Zahel, C. Herwig:
"Tools and Workflows to enable robustness of bioprocesses";
Vortrag: Smart Sensors - mechanistic and data driven modeling,
Frankfurt/Main, Deutschland (eingeladen);
01.10.2018
- 02.10.2018; in: "Book of Abstracts",
(2018),
S. 6.
P. Kroll, S. Ulonska, J. Kager, C. Herwig:
"Ermöglichung kontinuierlicher Bioprozessführung durch Modelle, Data Science und PAT";
Vortrag: 13. Kolloquium Prozessanalytik: Prozessführung in der modernen Produktion,
Esslingen, Deutschland (eingeladen);
21.11.2017
- 22.11.2017; in: "Programm",
(2017),
S. 39.
P. Kroll, S. Ulonska, I. Stelzer, C. Herwig:
"Multi-parametric control workflow of bioprocesses using mechanistic models";
Vortrag: EuroPACT 2017 - 4th European Conference on Process Analytics and Control Technology,
Potsdam, Deutschland (eingeladen);
10.05.2017
- 12.05.2017; in: "Book of Abstracts",
(2017),
S. 52.
T. Langemann, A. Meitz, P. Sagmeister, C. Herwig:
"Bacterial Ghost Platform Technology for Pharmaceutical Protein Production";
Vortrag: ICPE - 6th International Congress on Pharmaceutical Engineering,
Graz;
16.06.2014
- 17.06.2014; in: "Book of Abstracts",
(2014),
S. 18.
M. Lesniak, M. Weissgram, S. Pober, S. Pflügl, C. Herwig:
"Continuous Butanol Production from Spent Sulfite Liquor with Clostridium saccharoperbutylacetonicum";
Poster: Workshop on ABE Production and CO2/H2 Fermentation,
Wien;
10.11.2016
- 11.11.2016; in: "Book of Abstracts",
(2016),
S. 12.
B. Lorantfy, S. Bernacchi, E. Martinez Porqueras, C. Herwig:
"Restructurization of Renewable Energy Sources for more Efficient Biofuel Productions with Extremophilic Microorganisms";
Vortrag: EnInnov 2014 - 13. Symposium Energieinnovation,
Graz;
12.02.2014
- 14.02.2014; in: "EnInnov 2014",
(2014),
ISBN: 978-3-85125-310-8;
S. 409
- 410.
B. Lorantfy, C. Herwig:
"Quantitative bioprocess development and bioproduct profiling with extreme halophile microorganisms";
Vortrag: Halophiles 2013,
Storrs, CT, USA;
23.06.2013
- 27.06.2013; in: "Program and Abstracts",
(2013),
S. 57.
T. Mainka, C. Herwig, S. Pflügl:
"Bioprocess Development for Continuous Treatment of Industrial Waste Salt Water";
Vortrag: 18. Österreichische Chemietage,
Linz;
24.09.2019
- 27.09.2019; in: "18. Österreichische Chemietage",
(2019),
Paper-Nr. MS-55,
1 S.
T. Mainka, C. Herwig, S. Pflügl:
"Efficient microbial degradation of organic pollutants from industrial saline process streams using extreme halophilic Haloferax mediterranei";
Vortrag: SIMB Annual Meeting and Exhibition 2019,
Washington D.C., USA;
21.07.2019
- 24.07.2019; in: "https://sim.confex.com/sim/2019/meetingapp.cgi/Person/39372",
(2019),
Paper-Nr. S6,
1 S.
M. Marchetti-Deschmann, M. Helmel, A. Posch, C. Herwig, G. Allmaier:
"Monitoring the fermentation process of P. chrosgenum by combining a gel-based proteomics approach and intact cell mass spectrometry";
Vortrag: 5th Central and Eastern European Proteomic Conference,
Prague, Czech Republic;
19.09.2011
- 22.09.2011; in: "5th Central and Eastern European Proteomic Conference Book of Abstracts",
(2011),
S. 32.
T. Natschläger, B. Dorninger, C. Lettner, C. Herwig:
"Computational Model Environment: Visionen, Konzepte und Werkzeuge jenseits der Modeii-Kalibrierung";
Vortrag: 11. Kolloquium Arbeitskreis Prozessanalytik der DECHEMA und der GDCh-Fachgruppe Analytische Chemie,
Wien;
30.11.2015
- 02.12.2015; in: "Tagungsband",
(2015),
S. 34.
W. Nischkauer, C. Herwig, F. Vanhaecke, A. Limbeck:
"Dried-droplet Laser-Ablation in combination with ICP-OES and ICP-MS for the determination of major and minor elements in heavily matrix-loaded fermentation media";
Poster: 2014 Winter Conference on Plasma Spectrochemistry,
Amelia Island, Florida, US;
06.01.2014
- 11.01.2014; in: "2014 Winter Conference Program and Abstracts",
(2014),
ISSN: 0161-6951;
145 S.
Zusätzliche Informationen
W. Nischkauer, F. Vanhaecke, C. Herwig, A. Limbeck:
"Quantification of micro nutrients in fermentation media using LA-ICP-OES/MS analysis of dried sample droplets";
Vortrag: European Symposium on Atomic Spectrometry 2014,
Prag, Czech Republic;
16.03.2014
- 21.03.2014; in: "Book of Abstracts",
(2014),
ISBN: 978-80-905704-1-2;
104 S.
Zusätzliche Informationen
K. Novak, L. Flöckner, A. Erian, P. Freitag, C. Herwig, S. Pflügl:
"Overexpression of an acetylation-insensitive acetyi-CoA synthetase in E. coli Wand its effect on glucose and acetate co-utilization in batch and continuous cultures";
Poster: 10th ÖGMBT Annual Meeting,
Vienna;
17.09.2018
- 20.09.2018; in: "Abstract Book",
(2018),
S. 84.
K. Novak, L. Flöckner, A. Erian, P. Freitag, C. Herwig, S. Pflügl:
"Overexpression of an acetylation-insensitive acetyl-CoA synthetase in E. coli W and its effect on glucose and acetate co-utilization in batch and continuous cultures";
Poster: ESBES 2018 - European Symposium on Biochemical Engineering Sciences,
Lissabon, Portugal;
09.09.2018
- 12.09.2018; in: "Book of Abstracts",
(2018),
1 S.
K. Paul, B. Mitic, G. Scherfler, C. Herwig:
"Application of a 2-compartment system (2-CS) to study large-scale heterogeneity";
Poster: 26th ESACT Meeting,
Kopenhagen, Dänemark;
05.05.2019
- 08.05.2019; in: "Abstracts",
(2019),
S. 243.
K. Paul, V. Rajamanickam, C. Herwig:
"Model-based prediction of temperature and pH shift to increase volumetric productivity of a chinese hamster ovary cell fed-batch process (L08)";
Vortrag: 5th BioProScale Symposium,
Berlin, Deutschland;
20.03.2018
- 22.03.2018; in: "Abstract Booklet",
(2018),
S. 15.
A. Posch, C. Herwig:
"Process orientated quantification of metabolic and morphologic response behavior in Penicillium chrysogenum";
Poster: ESBES - 8th European Symposium on Biochemical Engineering Science,
Bologna, Italien;
05.09.2010
- 08.09.2010; in: "Book of Abstracts",
(2010),
S. 265.
A. Posch, C. Herwig:
"Towards science-based process design in filamentous fungi";
Poster: 10th European Conference on Fungal Genetics,
Leiden, Niederlande;
29.03.2010
- 01.04.2010; in: "Meeting Abstracts",
(2010),
S. 165.
A. Posch, C. Herwig:
"Unraveling the linkage of morphology and physiology in filamentous fungi by combining PAT tools with automated high-throughput microscopy";
Poster: 2011 Einsteins in the City,
New York, USA;
14.04.2011
- 15.04.2011; in: "Abstract Booklet",
(2011).
V. Rajamanickam, S. Capone, C. Herwig, O. Spadiut:
"Impurity monitoring of a recombinant SuperMan5 strain during dynamic upstream process";
Vortrag: Pichia 2016 Conference,
Antalya, Türkei;
03.04.2016
- 06.04.2016; in: "Abstract Book",
(2016),
S. 30.
V. Rajamanickam, C. Herwig, O. Spadiut:
"DSP development for small glycoproteins from yeast using monolithic supports";
Poster: Pichia 2016 Conference,
Antalya, Türkei;
03.04.2016
- 06.04.2016; in: "Abstract Book",
(2016),
S. 53.
V. Rajamanickam, C. Herwig, O. Spadiut:
"Implementaion of Monolithic Chromatography for Efficient Purification of Recombinant Glycoproteins from Yeast";
Vortrag: 7th Monolith Summer School and Symposium,
Portoroz, Slowenien (eingeladen);
27.05.2016
- 01.06.2016; in: "Abstract Book",
(2016),
S. 38.
V. Rajamanickam, D. Wurm, C. Herwig, O. Spadiut:
"A Novel PAT Toolbox to Facilitate Monitoring of E. Coli Bioprocess";
Vortrag: 7th Monolith Summer School and Symposium,
Portoroz, Slowenien (eingeladen);
27.05.2016
- 01.06.2016; in: "Abstract Book",
(2016),
S. 16.
D. Rial, C. Dietzsch, C. Herwig:
"Comprehensive characterization of recombinant Pichia pastoris using dynamic process conditions and process analytical technology";
Poster: 14th European Congress on Biotechnology,
Barcelona, Spanien;
13.09.2009
- 16.09.2009; in: "Abstracts of the 14th European Congress on Biotechnology",
New Biotechnology / Elsevier,
25 (Supplement)
(2009),
ISSN: 1871-6784;
S. 204
- 205.
V. Seidl-Seiboth, S. Zach, A. Frischmann, O. Spadiut, C. Dietzsch, C. Herwig, C.P. Kubicek:
"Functional analysis and structural features of fungal LysM chitin-binding proteins";
Poster: 4th ÖGMBT Annual Meeting,
Graz;
17.09.2012
- 19.09.2012; in: "Abstract Book 2012",
(2012),
S. 91.
P. Sinner, J. Kager, S. Daume, C. Herwig:
"Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste";
Vortrag: FOSBE 2019 - 8th IFAC Conference on Foundations of Systems Biology in Engineering,
Valencia, Spanien;
15.10.2019
- 18.10.2019; in: "Program Booklet",
(2019),
S. 22
- 23.
C. Slouka, G. Brunauer, J. Kopp, M. Strahammer, J. Fricke, J. Fleig, C. Herwig:
"Low frequency impedance spectroscopy as on- and inline tool for VIABLE BIOMASS measurements of S. cerevisiae";
Poster: 30th International VHYC Yeast Conference,
Berlin, Deutschland (eingeladen);
24.04.2017
- 25.04.2017; in: "http://www.vh-berlin.org/wp-content/uploads/2017/03/170330-Abstracts-30-VHYC.pdf",
(2017),
1 S.
A. Sonnleitner, C. Dißauer, S. Martini, B. Drosg, K. Meixner, L. Rachbauer, Z. Lazarova, C. Herwig, G. Kinger, I. Kofler, C. Strasser:
"Novel concepts for CO2 utilisation to produce value added products";
Poster: 5. Central European Biomass Conference,
Graz;
18.01.2017
- 20.01.2017; in: "Tagungsband/ Proceedings",
(2017),
ISBN: 978-3-9504380-1-7;
S. 227.
O. Spadiut, C. Dietzsch, F. Krainer, T. Hajek, A. Glieder, C. Herwig:
"Playing with the methanol utilization pathway in Pichia pastoris";
Vortrag: Pichia 2012 Conference,
Alpbach;
29.02.2012
- 03.03.2012; in: "Abstract Book",
(2012),
S. 43
- 44.
O. Spadiut, C. Herwig:
"Stability studies with the multifunctional enzyme horseradish peroxidase";
Vortrag: IIR Workshop 2013 on Cryoprocessing of Biopharmaceuticals and Biomaterials,
Dresden, Deutschland;
04.09.2013
- 05.09.2013; in: "Book of Abstracts",
(2013),
ISBN: 978-2-36215-001-2;
S. 25.
I. Stelzer, J. Kager, C. Herwig:
"Application of particle filter algorithms for monitoring of bioprocesses";
Vortrag: CEN ISBS Vienna 2017, Joint Conference on Biometrics & Biopharmaceutical Statistics,
Wien;
28.08.2017
- 01.09.2017; in: "Abstract Book",
(2017),
S. 82.
S. Ulonska, I. Stelzer, C. Herwig:
"Development of a multi-parametric control strategy for E. coli fedbatch processes using MPC and mechanistic models";
Poster: EuroPACT 2017 - 4th European Conference on Process Analytics and Control Technology,
Potsdam, Deutschland;
10.05.2017
- 12.05.2017; in: "Book of Abstracts",
(2017),
S. 130.
P. Wechselberger, C. Herwig:
"On-line characterisation and stress analysis for bioprocesses";
Poster: 5.Minisymposium Verfahrenstechnik,
Wien;
24.06.2009
- 25.06.2009; in: "5.Minisymposium Verfahrenstechnik - Tagungsband",
(2009),
ISBN: 978-3-9502731-0-6;
S. 13
- 17.
P. Wechselberger, C. Herwig:
"On-line characterisation and stress analysis for bioprocesses";
Poster: Arbeitskreis Prozessanalytik - 5.Kolloquium,
Göttingen, Deutschland;
30.11.2009
- 01.12.2009; in: "Arbeitskreis Prozessanalytik - 5.Kolloquium - Tagungsband",
(2009),
S. 32
- 36.
P. Wechselberger, C. Herwig:
"Real time fermentation process characterization for Quality by Design approaches";
Vortrag: ICPE - 5th International Congress on Pharmaceutical Engineering,
Graz;
29.09.2011
- 30.09.2011; in: "Book of Abstracts",
(2011),
S. 33.
P. Wechselberger, C. Herwig:
"Real-time Quantification of Specific Rates in Bioprocesses";
Poster: ESBES - 8th European Symposium on Biochemical Engineering Science,
Bologna, Italien;
05.09.2010
- 08.09.2010; in: "Book of Abstracts",
(2010),
S. 272.
M. Weissgram, C. Herwig:
"Potential improvement of the ABE fermentation process using a physiological and methodological approach";
Vortrag: Workshop on ABE Fermentation,
Wien;
23.07.2015
- 24.07.2015; in: "Workshop on ABE Fermentation - commercialisation status and hurdles",
(2015),
ISBN: 978-3-200-04223-0.
K. Wieland, C. Koch, R El-Zahry, J. Ofner, H. Grothe, J. Lohninger, C. Herwig, B. Lendl:
"Hyperspectral imaging of hyphae and spores of P. chrysogenum using confocal Raman spectroscopy and SERS";
Poster: XXIV. International Conference On Raman Spectroscopy,
Jena, Germany;
10.08.2014
- 15.08.2014; in: "ICORS Program",
(2014).
D. Wurm, B. Eggenreich, C. Herwig, G. Berghammer, O. Spadiut:
"The time has come: lntroducing QbD into inclusion body refolding processes";
Vortrag: 10th ÖGMBT Annual Meeting,
Vienna;
17.09.2018
- 20.09.2018; in: "Abstract Book",
(2018),
S. 88.
D. Wurm, C. Herwig, O. Spadiut:
"Teaching an old pET new Tricks Expression - Tuning in E.coli BL21(DE3)";
Vortrag: VSS 2017 - Vienna young Scientists Symposium,
Wien;
01.06.2017
- 02.06.2017; in: "Book of Abstracts",
(2017),
ISBN: 978-3-9504017-5-2;
S. 50
- 51.
T. Zahel, P. Sagmeister, S. Suchocki, C. Herwig:
"Advanced Information Mining from Fermentation Processes Using Dynamic Window Adaption";
Poster: 11. Kolloquium Arbeitskreis Prozessanalytik der DECHEMA und der GDCh-Fachgruppe Analytische Chemie,
Wien;
30.11.2015
- 02.12.2015; in: "Tagungsband",
(2015),
S. 48.
Vorträge und Posterpräsentationen (ohne Tagungsband-Eintrag)
S. Daume, J. Kager, C. Herwig:
"Time Resolved Sensitivity & Identifiability Analysis for Directed Parametrization of Highly Dynamic Models";
Poster: ESCAPE 29 - 29th European Symposium on Computer Aided Process Engineering,
Eindhoven, Niederlande;
16.06.2019
- 19.06.2019.
C. Dietzsch, O. Spadiut, C. Herwig:
"A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris";
Poster: Bio Production Forum,
Ulm, Deutschland;
08.06.2011
- 10.06.2011.
C. Dietzsch, O. Spadiut, C. Herwig:
"A novel on-line monitoring device for fast and quantitative bioprocess development";
Poster: 15th European Congress on Biotechnology,
Istanbul, Türkei;
23.09.2012
- 26.09.2012.
B. Eggenreich, V. Rajamanickam, C. Herwig, O. Spadiut:
"A fast approach to monitor inclusion body downstream processing steps of a Dietary scFv as a possible treatment of celiac disease";
Poster: 1. European Antibody Congress,
Basel, Schweiz;
14.11.2016
- 16.11.2016.
D. Ehgartner, J. Fricke, C. Herwig:
"Monitoring interactions of process parameters, morphology and process performance in Penicillium chrysogenum bioprocesses";
Poster: BIOPRO World Talent Campus,
Sorø, Dänemark;
15.08.2015
- 22.08.2015.
D. Ehgartner, C. Herwig, J. Fricke, A. Schröder:
"Evaluating viability and morphology of filamentous fungi using large-particle flow cytometry";
Vortrag: The Leading Edge in Cytometry,
Bad Nauheim, Deutschland (eingeladen);
22.09.2016
- 23.09.2016.
D. Ehgartner, T. Klein, C. Herwig, L. Neutsch:
"Flow cytometry as an at-line method for spore viability determination and monitoring of spore germination in bioprocesses with filamentous fungi";
Poster: Bioprocess Engineering Course 2014,
Brac, Kroatien;
21.09.2014
- 27.09.2014.
J. Fricke, C. Herwig:
"Which Outputs of a CFD Simulation Really Affect Process Performance? A Two-Step Scale-Down Approach";
Vortrag: PEGS Europe 2015,
Lissabon, Portugal (eingeladen);
02.11.2015
- 06.11.2015.
M. Helmel, M. Marchetti-Deschmann, A. Posch, C. Herwig, G. Allmaier:
"Differentiation and characterization of Penicillium chrosgenum under transient conditions by intact cell mass spectrometry and 2D gel electrophoresis-based proteomic approach";
Vortrag: AB Tec Day 2012,
TU Wien;
01.02.2012.
M. Helmel, M. Marchetti-Deschmann, A. Posch, C. Herwig, G. Allmaier:
"Intact cell mass spectrometry and 2D-gel electrophoresis to characterize the fermentation process of filamentous fungi";
Vortrag: AB Tec Tag 2013,
Vienna University of Technology (eingeladen);
15.02.2013.
M. Helmel, M. Marchetti-Deschmann, A. Posch, C. Herwig, G. Allmaier:
"Intact cell mass spectrometry as a novel tool for identification and characterization of microorganisms exemplified on filamentous fungi";
Vortrag: The Topical Issues of Mineral Resources Management,
National Mineral Resources University, St. Petersburg;
24.04.2013
- 26.04.2013.
M. Helmel, M. Marchetti-Deschmann, A. Posch, C. Herwig, G. Allmaier:
"Investigating the growth of Penicillium chrogenum in a bioreactor by pattern recognition based on intact cell mass spectrometry and process proteomics";
Poster: 9th Austrian Proteomics Research Symposium - Special focus on clinical proteomics,
Wien;
08.11.2011
- 09.11.2011.
M. Helmel, M. Marchetti-Deschmann, A. Posch, C. Herwig, G. Allmaier:
"Investigation of the expression profile of proteins from Penicillium chrysogenum during a fermentation process";
Poster: 10th Austrian Proteomic Research Symposium,
Graz;
24.09.2012
- 26.09.2012.
C. Herwig:
""Quicker Ways to a Scalable Process Based on Sound Science Based Methodologies" Processing Strategies to Understand the Production Platform and to Allow Transferability from Scale to Scale and from Product to Product";
Vortrag: 8th Annual European Bio Innovation Leaders Summit + QbD Master Class,
London, UK (eingeladen);
10.02.2015
- 11.02.2015.
C. Herwig:
""Why" using multivariate information processing - A concept beyond the "How" design space";
Vortrag: 10th Annual BioProduction,
Berlin, Deutschland;
24.10.2012
- 25.10.2012.
C. Herwig:
"A Development Strategy for Continuous Processing Using Concomitant lmpurity Monitoring";
Vortrag: BioProduction 2015,
Dublin, Irland (eingeladen);
14.10.2015
- 15.10.2015.
C. Herwig:
"A Mechanistic Approach for Accelerating Bioprocess Development";
Vortrag: Kolloquium der Fakultät Maschinenwesen, TU Dresden,
Dresden, Deutschland (eingeladen);
02.12.2014.
C. Herwig:
"A Novel PAT Tool for Impurity Monitoring";
Vortrag: BioProcess International European Summit,
Wien (eingeladen);
12.04.2016
- 13.04.2016.
C. Herwig:
"A Quantitative Scale Down Approach Using Physiological Understanding and Modelling";
Vortrag: Cell Culture & Bioprocessing Forum,
Berlin, Deutschland (eingeladen);
01.10.2014
- 02.10.2014.
C. Herwig:
"Adjusting control strategies using Digital Twins";
Vortrag: Advanced Therapies Congress 2020 (Online Conference),
London, UK (eingeladen);
07.09.2020
- 09.09.2020.
C. Herwig:
"Assessment of data quality and Know - Why - A scalable QbD Approach";
Vortrag: Biological Production Forum 2013,
Düsseldorf, Deutschland;
24.09.2013.
C. Herwig:
"Bio Process - Analytics -Understanding - Analytical Technology";
Vortrag: ISPE Basel,
Basel, Schweiz;
08.10.2010.
C. Herwig:
"BioABC - Biologische Umwandlung von Abfall zu Butanol mit CO2 Fixierung";
Vortrag: Stakeholderdialog Biobased Industry: Ressourceneffiziente Bioraffinerie - Konversion von Sekundärrohstoffen,
Wien (eingeladen);
07.12.2018.
C. Herwig:
"Biofuels and CO2 neutrality : an opportunity";
Vortrag: 1. Bio Ökonomie Kongress,
Stuttgart, Deutschland (eingeladen);
29.10.2014
- 30.10.2014.
C. Herwig:
"Biokraftstoffe bis zur fünften Generation - CO2 Neutralität und Hybrid-Prozesse";
Vortrag: 724. DECHEMA-Kolloquium,
Frankfurt, Deutschland (eingeladen);
27.10.2014.
C. Herwig:
"Bioprocess technology approaches and tunable promoters for continuous processing";
Vortrag: BioProduction 2014,
Barcelona, Spanien (eingeladen);
08.10.2014
- 09.10.2014.
C. Herwig:
"Bioprocessing of extemophiles - Hybrid solutions for biofuls and biobased materials";
Vortrag: Kolloquium der Fakultät, KIT,
Karlsruhe, Deutschland (eingeladen);
28.10.2014.
C. Herwig:
"Challenges for Pharma 4.0 concepts and technologies";
Vortrag: How Artificial Intelligence and Big Data are Driving the Digital Transformation in the Pharmaceutical Industry (Online Conference),
Wien (eingeladen);
21.05.2021.
C. Herwig:
"Common denominators of process and life cycle control strategies";
Vortrag: BioTalk US 2019,
Boston, USA (eingeladen);
22.05.2019
- 23.05.2019.
C. Herwig:
"Common denominators of process and life cycle control strategies";
Vortrag: Bio Talk EU 2019 - Biological Manufacturing Excellence,
Berlin, Deutschland (eingeladen);
23.09.2019
- 24.09.2019.
C. Herwig:
"Control Strategy - The Foundation of Success";
Vortrag: ISBioTech 5th Fall Meeting,
Virginia Beach, VA, USA (eingeladen);
11.12.2017
- 13.12.2017.
C. Herwig:
"CQA lmpurity Monitaring for lntegrated Bioprocessing";
Vortrag: BioProcess International Conference & Exposition,
Boston, MA, USA (eingeladen);
26.10.2015
- 29.10.2015.
C. Herwig:
"Data Quality , data consistency and conversion in information";
Vortrag: Workshop on Methods for Accelerating Scalable Bioprocess Development,
Wien;
09.11.2016
- 11.11.2016.
C. Herwig:
"Data Science for Pharma 4.0 - Enablers, Prerequisites and Potential";
Vortrag: International Conference on "Pharma Industry 4.0",
Athen, Griechenland (eingeladen);
22.10.2021
- 23.10.2021.
C. Herwig:
"Data Science is the Enabler for Accelerating Technology Transfer and Process Validation";
Vortrag: Bio Talk US 2020 (Online Conference),
London, UK (eingeladen);
19.10.2020
- 23.10.2020.
C. Herwig:
"Data Science is the Enabler for Accelerating Technology Transfer and Process Validation";
Vortrag: Bio Talk EU 2020 (Online Conference),
London, UK (eingeladen);
05.10.2020
- 09.10.2020.
C. Herwig:
"Data Science or PAT as Control Strategies for Continuous Biomanufacturing";
Vortrag: BioProcess International Spring Digital Week (Online Conference),
New York, USA (eingeladen);
15.06.2020
- 24.06.2020.
C. Herwig:
"Data Science workflows for Process Characterisaton and Continuous Process Verification";
Vortrag: 2018 ISPE Europe Aseptic Conference,
Wien (eingeladen);
28.11.2018
- 29.11.2018.
C. Herwig:
"Data to Knowledge in Real-time - Efficient Methods for Bioprocess Understanding";
Vortrag: International Conference Centenary of Education in Chemical Engineering,
Iasi, Rumänien (eingeladen);
28.11.2012
- 30.11.2012.
C. Herwig:
"Delivering knowledge to product quality and quantity for bioproducts - catalyzing start-ups from ideas to commercialization";
Vortrag: life-science-success 2012,
Wien;
20.03.2012.
C. Herwig:
"Development and characterization of integrated processes using data science tools";
Vortrag: Cell Culture & Downstream Processing World Congress 2017,
München, Deutschland (eingeladen);
21.02.2017
- 22.02.2017.
C. Herwig:
"Digital twin assisted acceleration of bioproces characterization and validation";
Vortrag: 13th Annual BioInnovation Leaders Summit,
Berlin, Deutschland (eingeladen);
05.02.2020
- 06.02.2020.
C. Herwig:
"Digitalisierung in der biobasierten Prozessindustrie";
Vortrag: Produktion der Zukunft - Stakeholderdialog Biobased Industry,
Wien (eingeladen);
23.11.2016.
C. Herwig:
"Echtzeitmessung von multiplen Komponenten am Bioreaktor - Herausforderung und Nutzen";
Vortrag: 8. Workshop Biochromatographie "Bio unter Hochdruck",
Biberach an der Riß, Deutschland;
29.07.2013
- 01.08.2013.
C. Herwig:
"Enabling Continuous Manufacturing through Data Science, Modelling and Advanced PAT Tools";
Vortrag: The Bioprocessing Summit 2017,
Boston, USA (eingeladen);
21.08.2017
- 25.08.2017.
C. Herwig:
"Enabling continuous manufacturing through data science, modelling and advanced PAT tools";
Vortrag: BioProduction Congress 2017,
Dublin, Irland (eingeladen);
17.10.2017
- 18.10.2017.
C. Herwig:
"Enabling Continuous Manufacturing Through Process Characterisation Tools";
Vortrag: ISPE European Conference on Biotechnology 2017,
Dublin, Irland (eingeladen);
26.09.2017
- 27.09.2017.
C. Herwig:
"Enabling Continuous Upstream Bioprocessing - Using Tunable Promoters and Model Based Control Tools";
Vortrag: Bioprocessimg Summit Europe 2018,
Lissabon, Portugal (eingeladen);
20.03.2018
- 22.03.2018.
C. Herwig:
"Enabling Process Understanding, Process Control and Process Knowledge inside of the Process Life Cycle";
Vortrag: ZETA Symposium,
Graz (eingeladen);
24.01.2017
- 26.01.2017.
C. Herwig:
"Enabling Smooth Product Life Cycling - Process Characterization on Sound Data Science and QbD Tools";
Vortrag: PHARM Connect Congress,
Budapest, Ungarn (eingeladen);
13.03.2018
- 14.03.2018.
C. Herwig:
"Fully understanding the link between process development and manufacturing using platform knowledge";
Vortrag: 11th Annual Biological Production Forum,
Düsseldorf, Deutschland;
24.09.2012
- 26.09.2012.
C. Herwig:
"Gathering scientifically based process understanding in real time - PAT is more than on-line monitoring";
Vortrag: Process Analytical Technologs (PAT) in Biotechnology,
Basel, Schweiz;
26.11.2009.
C. Herwig:
"General Development Strategy";
Vortrag: Workshop on Methods for Accelerating Scalable Bioprocess Development,
Wien;
09.11.2016
- 11.11.2016.
C. Herwig:
"Generic tools accelerating bioprocess development- equally applied to biopharmaceuticals and sustainables";
Vortrag: Novel Concepts in Biosustainability,
Kopenhagen, Dänemark;
18.12.2013.
C. Herwig:
"Integrated Approaches for Single Use Facilities";
Vortrag: Single Use Biopharmaceutical Facilities,
Istanbul, Türkei (eingeladen);
15.12.2013
- 17.12.2013.
C. Herwig:
"Integrated bioprocess robustness enabled by data science and model based tools";
Vortrag: Seminar ChemE, Department of Chemical Engineering, MIT,
Cambridge, MA, USA (eingeladen);
17.05.2018.
C. Herwig:
"Integrated digital twins and control strategies to ensure product life cycling";
Vortrag: 2nd European Forum on New Technologies,
Frankfurt, Deutschland (eingeladen);
01.03.2019.
C. Herwig:
"Integrierte Prozessmodellierung: Ein Begleiter von der Prozessentwicklung zur Steuerungsstrategie";
Vortrag: 5. Jahrestagung Prozessvalidierung (Online-Konferenz),
Köln, Deutschland (eingeladen);
16.03.2020
- 17.03.2020.
C. Herwig:
"Life Cycle Management per Q12: Using Digital Twins and Control Strategies";
Vortrag: 2018 ISPE Annual Meeting & Expo,
Philadelphia, USA (eingeladen);
04.11.2018
- 07.11.2018.
C. Herwig:
"lntegrated bioprocess robustness enabled by data science and model based tools";
Vortrag: BioTalk - Biological Manufacturing Excellence,
Berlin, Deutschland (eingeladen);
19.09.2018
- 20.09.2018.
C. Herwig:
"lntegrated digital twin solution for the bioprocess validation life cycle";
Vortrag: 2nd Global Bioprocessing, Bioanalytics and ATMP Manufacturing Congress,
Dublin, Irland (eingeladen);
20.05.2019
- 21.05.2019.
C. Herwig:
"lntegrated digital twins for the bioprocess validation lifecycle";
Vortrag: Himmelfahrtstagung 2019: Intensification and digitalisation for integral bioprocessing,
Hamburg, Deutschland (eingeladen);
27.05.2019
- 29.05.2019.
C. Herwig:
"Methods for accelerating bioprocess development and ensuring scale up";
Vortrag: Turkey-Iran Regional Workshop on Biotech Drugs and Vaccines: Challenges and Opportunities,
Istanbul, Türkei (eingeladen);
20.11.2015
- 21.11.2015.
C. Herwig:
"Methods for scalability, efficiency and quality increase productivity and shorten development times";
Vortrag: The Annual Pharmaceutical Innovation & Manufacturing Strategies Leaders Summit 2013 London,
London, UK (eingeladen);
12.02.2013
- 13.02.2013.
C. Herwig:
"Mikrobieller Abbau von organischen Verunreinigungen in Salzlösungen";
Vortrag: DECHEMA-Kolloquium "Recycling von Neutralsalz-haltigen Prozessabwässern",
Leverkusen, Deutschland (eingeladen);
27.09.2018.
C. Herwig:
"Monitoring Cell Populations and Tunable Promoters for Robust Continuous Upstream Processing";
Vortrag: BioProcess International Spring Digital Week (Online Conference),
New York, USA (eingeladen);
15.06.2020
- 24.06.2020.
C. Herwig:
"Multi-Parametric Control Strategies for Enabling Continuous Biomanufacturing";
Vortrag: World Biopharm Forum 2017,
Oxford, UK (eingeladen);
26.06.2017
- 28.06.2017.
C. Herwig:
"Multi-Parametric Control Strategies for Enabling Continuous Biomanufacturing";
Vortrag: ISBioTech 5th Fall Meeting,
Virginia Beach, VA, USA (eingeladen);
11.12.2017
- 13.12.2017.
C. Herwig:
"Multi-parametric control strategies for enabling continuous biomanufacturing";
Hauptvortrag: APACT 18 - Advances in Progress Analytics and Control Technology 2018 Conference,
Newcastle, UK (eingeladen);
25.04.2018
- 27.04.2018.
C. Herwig:
"Optimierung biotechnischer Prozesse zur effizienten Herstellung grüner Chemikalien";
Vortrag: 5. Fachdialog Grüne Chemie,
Wien (eingeladen);
25.11.2021.
C. Herwig:
"Optimization for cell culture processes using Digital twin based design approaches";
Vortrag: Bio Talk EU 2020 (Online Conference),
London, UK (eingeladen);
05.10.2020
- 09.10.2020.
C. Herwig:
"Overcoming Issues of Control - What are the Tools Needed for Controlling a Continuous Process";
Vortrag: BioProcess International 2019,
Boston, MA, USA (eingeladen);
09.09.2019
- 12.09.2019.
C. Herwig:
"PAT beyond an analytical tool - reduce data to knowledge in real-time for process optimisation tasks";
Vortrag: The 6th Annual Bio Manufacturing & Process Innovation Leaders Summit 2013,
London, UK (eingeladen);
12.02.2013
- 13.02.2013.
C. Herwig:
"PAT tools for horizontal monitoring across entire process chain & advanced data science tools for developing platform knowledge and scalable knowledge";
Vortrag: Downstream Processing World Congress 2016,
München, Deutschland (eingeladen);
23.02.2016
- 24.02.2016.
C. Herwig:
"PAT, Data Science and Digital Twin based Control Strategies for Integrated Continuous Bioprocessing";
Vortrag: BioProcess International US West (Online Conference),
Boston, USA (eingeladen);
29.03.2021
- 31.03.2021.
C. Herwig:
"Perspective on Implementing ICHQ10 Guidelines into the Bioprocess Life Cycle";
Vortrag: APV Workshop : Continuous Manufacturing,
Graz;
26.09.2012
- 27.09.2012.
C. Herwig:
"Pharmazeutische Prozesstechnologie";
Vortrag: Blocklehrveranstaltung, TU Graz,
Graz (eingeladen);
08.01.2014
- 09.01.2014.
C. Herwig:
"Problem statement & goals in bioprocess development";
Vortrag: Workshop on Methods for Accelerating Scalable Bioprocess Development,
Wien;
09.11.2016
- 11.11.2016.
C. Herwig:
"QbD in a dead and a mechanistic revival";
Vortrag: 10 Years FDA PAT/QbD - Quo Vadis Pharmaceutical Industry?,
Basel, Schweiz;
19.11.2013.
C. Herwig:
"QbD related Modelling and Control Tasks in Process Development";
Vortrag: European Symposium on Biochemical Engineering Sciences 2016,
Dublin, Irland (eingeladen);
11.09.2016
- 14.09.2016.
C. Herwig:
"Quality by Design driven approaches for reaching process robustness";
Vortrag: Bioprocessing Summit 2018,
Boston, USA (eingeladen);
13.08.2018
- 17.08.2018.
C. Herwig:
"Reviving QbD - A Mechanistic Approach";
Vortrag: Colloquium on Process Development,
Istanbul, Türkei (eingeladen);
17.01.2015.
C. Herwig:
"Reviving QbD - A Mechnistic Approach for Accelerating Bioprocess Development";
Vortrag: Biotechnet Olten Meeting 2013,
Olten, Schweiz (eingeladen);
29.11.2013.
C. Herwig:
"Reviving QpD A Mechanistic Approach";
Vortrag: IRR - "Quality in the Pharmaceutical Industry 2013",
Budapest, Ungarn (eingeladen);
24.06.2013
- 25.06.2013.
C. Herwig:
"Science-based Methods for Efficient Bioprocess Development";
Hauptvortrag: Discover your Future,
Prag, Tschechische Republik (eingeladen);
29.04.2013
- 30.04.2013.
C. Herwig:
"Strategies for Happy Cells in Induced Continuous Upstream Processes";
Vortrag: BioProduction 2019,
Frankfurt, Deutschland;
05.11.2019
- 07.11.2019.
C. Herwig:
"Technologizing ATMP Processes - Efficient methods to enhance product functionality";
Vortrag: 2021 Advanced Therapies Congress LIVE,
London, UK (eingeladen);
05.10.2021
- 06.10.2021.
C. Herwig:
"The QbD discussion leads into a dead-end street";
Vortrag: 10 Years FDA PAT/QbD - Quo Vadis Pharmaceutical Industry?,
Basel, Schweiz;
19.11.2013.
C. Herwig:
"Tolls for Accelerating Bioprocess Development";
Vortrag: Pall Symposium "Discover your future",
Berlin, Deutschland;
10.06.2013
- 11.06.2013.
C. Herwig:
"Tools for Accelerating Bioprocess Development";
Vortrag: 10th International Life Science Meeting,
Krems;
28.05.2013
- 29.05.2013.
C. Herwig:
"Trends und Herausforderungen der Digitalisierung in der Prozessindustrie";
Vortrag: Digitalisierung in der Prozessindustrie,
Wien (eingeladen);
01.06.2016
- 02.06.2016.
C. Herwig:
"Umgang mit vernetzten Daten in Bioproze";
Vortrag: BioProcessingFactory,
Aachen, Deutschland (eingeladen);
24.06.2019
- 26.06.2019.
C. Herwig:
"Using mechanistic understanding to enhance process understanding";
Vortrag: Pharma QbD Forum,
Berlin, Deutschland (eingeladen);
24.04.2012
- 25.04.2012.
C. Herwig:
"Utilizing Data Science and PAT Tools for Decision Making in the Bioprocess Life Cycle";
Vortrag: BioProcess International Europe,
Wien (eingeladen);
02.04.2019
- 05.04.2019.
C. Herwig:
"Workflows for Data Science Enabled Stage 1 Validation";
Vortrag: BioTalk US,
Boston, USA (eingeladen);
24.05.2018
- 25.05.2018.
C. Herwig:
"Workflows und Nutzen von Digitalen Zwillingen";
Hauptvortrag: Jahrestreffen der ProcessNet-Fachgemeinschaften "Prozess-, Apparate- und Anlagentechnik" unterstützt durch "Sustainable Production, Energy and Resources",
Dortmund, Deutschland (eingeladen);
04.11.2019
- 05.11.2019.
C. Herwig:
"Ziel und Methoden zur Verkürzung der Prozessentwicklungszeit";
Vortrag: Planar Workshop "Future Technologies",
Eben am Achensee;
13.03.2013
- 14.03.2013.
C. Herwig, O. Garcia-Aponte:
"Technologizing ATMP Processes - Efficient methods to enhance NK functionality";
Vortrag: Advanced Therapies Congress & Expo 2021 (Online Conference),
London, UK (eingeladen);
19.05.2021
- 21.05.2021.
C. Herwig, J. Kager:
"Digital Twin Based Optimization of cell cultures";
Vortrag: EFCE Spotlight Talks (Online Conference),
Frankfurt am Main, Deutschland (eingeladen);
23.11.2020
- 04.12.2020.
C. Herwig, J. Kopp:
"Control Strategies for Continuous Bioprocessing and Along the Lifecycle";
Vortrag: BioProcess International Europe,
Wien (eingeladen);
02.04.2019
- 05.04.2019.
C. Herwig, J. Schrooten:
"Tackling novel challenges: focusing on elements which are different from other cell culture processes";
Vortrag: Advanced Therapies Congress & Expo 2021 (Online Conference),
London, UK (eingeladen);
19.05.2021
- 21.05.2021.
A. Hobro, M. Garcia Torreiro, C. Herwig, B. Lendl:
"FTIR spectroscopic studies of yeast physiology under nutrient limited conditions Alison";
Poster: International Conference on Advanced Vibrational Spectrosopcy, ICVAS 5,
Melbourne;
12.07.2009
- 17.07.2009.
Zusätzliche Informationen
A. Hofer, J. Fricke, C. Herwig:
"In depth characterization of the metabolic adaption of Penicillium chrysogenum to complex raw material nutrients and specific sugars";
Vortrag: 15#{th} International Pharmaceutical Microbiology and Biotechnology Conference,
London, UK (eingeladen);
21.06.2017
- 23.06.2017.
A. Hofer, P. Kroll, C. Herwig:
"Automated sampling and sample processing in CHO processes for process monitoring and media development";
Poster: Biotech 2017,
Wädenswill, Schweiz;
07.09.2017
- 08.09.2017.
J. Kager, V. Berezhinskiy, R. Zimmerleitner, M. Brandstetter, C. Herwig:
"Extension of a Particle Filter for Bioprocess State Estimation using Invasive and Non-Invasive IR Measurements";
Vortrag: ESCAPE 29 - 29th European Symposium on Computer Aided Process Engineering,
Eindhoven, Niederlande;
16.06.2019
- 19.06.2019.
J. Kager, C. Herwig:
"Model based control of a penicillin production process";
Poster: BIOPRO World Talent Campus 2018,
Sorø, Dänemark (eingeladen);
18.08.2018
- 22.08.2018.
J. Kager, I. Stelzer, C. Herwig:
"Improving Bioprocesses by Physiological Process Control";
Poster: Workshop on Methods for Accelerating Scalable Bioprocess Development,
Wien;
09.11.2016
- 11.11.2016.
J. Kager, S. Ulonska, P. Kroll, C. Herwig:
"Multi-parametric Control of Bioprocesses using Mechanistic Models";
Poster: ProcessNet-Jahrestagung und 32. DECHEMA-Jahrestagung der Biotechnologen 2016,
Aachen, Deutschland;
12.09.2016
- 15.09.2016.
D. Kamravamanesh, S. Pflügl, M. Lackner, C. Herwig:
"Poly-β-hydroxybutyrate production from carbondioxide in cyanobacteria";
Poster: The 6th Conference on Carbon Dioxide as Feedstock for Fuels, Chemistry and Polymers,
Köln, Deutschland;
15.03.2018
- 16.03.2018.
C. Koch, H. Goicoechea, A. Posch, C. Herwig, B. Lendl:
"ATR FT-IR in-line monitoring of precursor and product in a P. chrysogenum fermentation";
Poster: IRDG Christmas Meeting 2014,
London, UK;
18.12.2014.
Zusätzliche Informationen
C. Koch, B. Lorantfy, M. R. Plata Torres, M. Brandstetter, S. Radel, C. Herwig, B. Lendl:
"Ultrasound enhanced ATR FTIR spectroscopy - acquiring spectra of cells inline during fermentation";
Poster: IRDG Christmas Meeting 2012 (200th),
University College London, London, UK;
20.12.2012.
J. Kopp, C. Slouka, H. Sassi, F. Delvigne, C. Herwig:
"Population heterogeneities in long-term chemostat E. coli cultivations determined with online & at-line flow-cytometry analysis";
Poster: BASF International Summer Course 2019,
Ludwigshafen, Deutschland;
11.08.2019
- 17.08.2019.
B. Lorantfy, C. Herwig:
"Integrated bioprocess development with extreme halophiles for carotenoid production";
Vortrag: 17th International Symposium on Carotenoids,
Park City, USA;
29.06.2014
- 04.07.2014.
T. Mainka, C. Herwig, S. Pflügl:
"Bioprocess Development for Continuous Treatment of Industrial Waste Salt Water";
Poster: 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Online-Konferenz),
Frankfurt am Main, Deutschland;
21.09.2020
- 24.09.2020.
T. Mainka, C. Herwig, S. Pflügl:
"Bioprocess Development for Continuous Treatment of Industrial Waste Salt Water";
Vortrag: e-Konferenz: Industrial Water 2020 (Online Konferenz),
Frankfurt am Main, Deutschland;
17.11.2020
- 19.11.2020.
E. Martinez Porqueras, C. Herwig:
"Coupling of BioH2 and BioCO2 Production for BioCH4 Production";
Vortrag: 19th European Biomass Conference and Exhibition,
Berlin, Deutschland;
06.06.2011
- 10.06.2011.
J. Pauk, L. Veiter, K. Koczka, C. Herwig:
"An integrated approach for monitoring and control of refolding kinetics by combining PAT and modelling";
Vortrag: 16. Kolloquium Prozessanalytik (Online Konferenz),
Frankfurt am Main, Deutschland;
23.11.2020
- 25.11.2020.
A. Posch, M. Helmel, C. Koch, M. Marchetti-Deschmann, B. Lendl, G. Allmaier, C. Herwig:
"A comprehensive toolbox for morphological and physiological bioprocess characterisation of filamentous fungi";
Vortrag: ProcessNet-Jahrestagung und 30. DECHEMA-Jahrestagung der Biotechnologen,
Karlsruhe, Deutschland;
10.09.2012
- 13.09.2012.
V. Rajamanickam, O. Spadiut, C. Herwig:
"Implementation of monolith chromatography for purification of recombinant glycoproteins expressed in yeast";
Poster: Biopartitioning & Purification Conference 2015,
Wien;
07.06.2015
- 10.06.2015.
W. Reichelt, M. Brillmann, P. Thurrold, C. Herwig:
"Transient physiologic states: friend or foe?";
Poster: Himmelfahrtstagung Dechema - Scale-up and scale-down of bioprocesses,
Hamburg, Deutschland;
11.05.2015
- 13.05.2015.
W. Reichelt, P. Keil, P. Wechselberger, C. Herwig:
"Transient Physiologic States: Friend or Foe?";
Poster: Bioprocess Engineering Course 2014,
Brac, Kroatien;
21.09.2014
- 27.09.2014.
W. Reichelt, P. Thurrold, M. Brillmann, J. Fricke, C. Herwig:
"Transient Physiologic States: Friend or Foe?";
Poster: SGS Industrial Bioprocess Development Academy,
Ludwigshafen, Deutschland;
15.04.2015
- 17.04.2015.
P. Sagmeister, C. Herwig:
"Bioreactor Mass & Energy Balances; Scaling Strategies & Benefits";
Vortrag: SYNPOL 1st Annual Course on "Industrial Fermentation Processes: Basics and Successful Industrial Scale-up Stories",
Valencia, Spanien (eingeladen);
08.11.2013.
A. Seifert, S. Rittmann, C. Herwig:
"Biomethane Production from Gaseous Substrates Using Methanogenic Archea";
Poster: 19th European Biomass Conference and Exhibition,
Berlin, Deutschland;
06.06.2011
- 10.06.2011.
A. Seifert, S. Rittmann, C. Herwig:
"Influence of gas/liquid mass transfer on the volumetric production rate and product quality during biological methanogenesis";
Vortrag: ProcessNet-Jahrestagung und 30. DECHEMA-Jahrestagung der Biotechnologen,
Karlsruhe, Deutschland;
10.09.2012
- 13.09.2012.
P. Sinner, C. Herwig, J. Kager:
"Time scale analysis and optimization of a continuous microbial bioprocess";
Poster: ESCAPE 30 - 30th European Symposium on Computer Aided Process Engineering (Online Conference),
Mailand, Italien;
30.08.2020
- 02.09.2020.
C. Slouka, J. Kopp, S. Hutwimmer, M. Strahammer, C. Herwig:
"Custom made inclusion bodies: Triggering QAs using classical process parameters like pH and T";
Poster: BASF International Summer Course 2017,
Ludwigshafen, Deutschland;
09/2017.
C. Slouka, D. Wurm, P. Kroll, C. Herwig:
"Kontinuierliche Upstream-Bioprozessführung mittels Modellen und regelbaren Promotoren";
Hauptvortrag: ProcessNet-Jahrestagung und 33. DECHEMA-Jahrestagung der Biotechnologen 2018,
Aachen, Deutschland (eingeladen);
10.09.2018
- 13.09.2018.
I. Stelzer, J. Kager, C. Herwig:
"Comparison of Particle Filter and Extended Kalman Filter Algorithms for Monitoring of Bioprocesses";
Poster: Symposium on Computer Aided Process Engineering - ESCAPE 27,
Barcelona, Spanien;
01.10.2017
- 05.10.2017.
E. Ullmann, T. Tan, T. Gundinger, C. Herwig, C. Divne, O. Spadiut:
"A novel cytosolic NADH: Quinone oxidreductase from Methanothermobacter marburgensis";
Poster: Biotrans 2015,
Wien;
26.07.2015
- 30.07.2015.
S. Ulonska, J. Kager, C. Herwig:
"Automatic controller failure detection with application in model based control of an E. coli fed-batch";
Vortrag: Escape28 - 28th European Symposium on Computer Aided Process Engineering,
Graz;
10.06.2018
- 13.06.2018.
S. Ulonska, P. Kroll, J. Fricke, C. Clemens, R. Voges, M. Müller, C. Herwig:
"Applying novel offline and real-time methods to an enhanced mechanistic cell culture mode";
Poster: 4th BioProScale Symposium,
Berlin, Deutschland;
06.04.2016
- 08.04.2016.
S. Ulonska, P. Kroll, C. Herwig:
"Good Modelling Practice";
Poster: Workshop on Advanced Methods in Bioprocess Development,
Wien;
10.06.2015
- 11.06.2015.
P. Wechselberger, C. Herwig:
"On-line Characterisation of Bioprocesses Enabling Continuous Improvement";
Poster: 23.VH Hefetagung,
Wien;
26.04.2010
- 27.04.2010.
K. Wieland, C. Koch, J. Kuligowski, J. Ofner, D. Ehgartner, C. Herwig, B. Lendl:
"Using PLS-DA to evaluate the quality of spore inoculum to optimize biotechnological process control";
Poster: CAC 2016 Chemometrics in Analytical Chemistry,
Barcelona;
06.06.2016
- 10.06.2016.
D. Wurm, B. Eggenreich, C. Herwig, O. Spadiut:
"Controlled Refolding of Inclusion Body Protein to Boost Product Yields";
Poster: BioProduction Congress 2017,
Dublin, Irland;
17.10.2017
- 18.10.2017.
D. Wurm, B. Lorantfy, M. Weissgram, C. Herwig:
"Halophilic Biomaterials - biomaterial characterizations with stepwise quantitative screening approaches";
Poster: Biomaterials - Made in Bioreactors (Dechema),
Radebeul, Deutschland;
26.05.2014
- 28.05.2014.
D. Zalai, P. Wechselberger, A. Putics, C. Herwig:
"Quality by design in cell culture development: enhanced process knowledge for physiological control strategies";
Vortrag: 10th European Congress of Chemical Engineering,
Nizza, Frankreich;
27.09.2015
- 01.10.2015.
Patente
S. Bernacchi, C. Herwig:
"Kulturstatusbestimmung";
Patent: Österreich,
Nr. At 697/2015;
eingereicht: 29.10.2015.
H. Heckroth, C. Herwig, D. Kamravamanesh:
"Biodegradation of Aniline from Hypersaline Environments Using Halophilic Microorganisms";
Patent: Europa,
Nr. Ep 2018/050431;
eingereicht: 10.01.2017.
H. Heckroth, C. Herwig, D. Kamravamanesh:
"Biodegradation of Aniline from Hypersaline Environments Using Halophilic Microorganisms";
Patent: International,
Nr. Wo 2018/130510 A1;
eingereicht: 09.01.2018.
H. Heckroth, C. Herwig, D. Kamravamanesh, P. Ruschitzka:
"Formate Catalysis from Hypersaline Environments by a Halotolerant Halomonas sp.";
Patent: Europa,
Nr. Ep 16185666 A 1;
eingereicht: 25.08.2016.
H. Heckroth, C. Herwig, D. Kamravamanesh, P. Ruschitzka:
"Formate Catalysis from Hypersaline Environments by a Halotolerant Halomonas sp.";
Patent: International,
Nr. Wo 2018/037081 A1;
eingereicht: 24.08.2017.
H. Heckroth, R. Weber, C. Herwig, N. Mahler:
"Continuous method for reducing the amount of organic compounds in wastewater";
Patent: Europa,
Nr. Ep 3 502 063 A1;
eingereicht: 19.12.2017.
C. Herwig, B. Lorantfy, E. Martinez Porqueras:
"Wertstoffproduktion mittels halophiler Mikroorganismen";
Patent: Europa,
Nr. Ep 2 712 919 B1;
eingereicht: 26.09.2013,
erteilt: 08.11.2017.
C. Herwig, S. Rittmann, B. Lorantfy, M. Jazini, G. Henssen:
"Method for the reduction of total organic carbon in hypersaline water";
Patent: International,
Nr. Wo 2013/124375 A2;
eingereicht: 21.02.2013.
C. Herwig, S. Rittmann, B. Lorantfy, M. Jazini, G. Henssen, W. Pohl:
"Method for the reduction of total organic carbon in hypersaline water";
Patent: Europa,
Nr. Ep 2 631 219 A1;
eingereicht: 22.02.2012,
erteilt: 28.08.2013.
C. Herwig, A. Seifert:
"Selektive Abtrennung von Wasser mittels Membranverfahren in einem anaeroben Bioprozess";
Patent: Europa,
Nr. Ep 2 919 893 B1;
eingereicht: 12.11.2013,
erteilt: 31.05.2017.
D. Kamravamanesh, C. Herwig, S. Pflügl, M. Lackner:
"Verfahren zum Mutieren von Cyanobakterien";
Patent: Österreich,
Nr. A 68/2018;
eingereicht: 13.03.2018.
A. Krajete, C. Herwig, S. Rittmann, A. Seifert, S. Bernacchi:
"Method and system for producing methane using methanogenic microorganisms and applying specific nitrogen concentrations in the liquid phase";
Patent: International,
Nr. Wo 2014/128300;
eingereicht: 24.02.2014,
erteilt: 28.08.2014.
N. Mahler, C. Herwig:
"Recycling of alkali sulfate rich waste water by biological pre-treatment with an extreme halophilic organism";
Patent: Deutschland,
Nr. EP18160929;
eingereicht: 09.03.2018.
E. Martinez Porqueras, B. Lorantfy, C. Herwig:
"Einsatz halophiler Mikroorganismen für die Produktion von Wertstoffen";
Patent: Österreich,
Nr. At 50413/2012;
eingereicht: 27.09.2012.
W. Reichelt, C. Herwig, J. Kager, P. Sagmeister, M. Funke:
"Improved fermentation process";
Patent: Europa,
Nr. EP16158294.5;
eingereicht: 02.03.2016.
W. Reichelt, C. Herwig, J. Kager, P. Sagmeister, M. Funke:
"Improved Fermentation Process";
Patent: International,
Nr. Wo 2017/149065;
eingereicht: 02.03.2017.
A. Seifert, C. Herwig:
"Selektive Abtrennung von Wasser bei gleichzeitiger Biomasse- und Medienkomponentenretention";
Patent: Österreich,
Nr. At 50508/2012;
eingereicht: 14.11.2012,
erteilt: 15.04.2014.
M. Weissgram, C. Herwig:
"Herstellung von 2,3 Butandiol";
Patent: Österreich,
Nr. At 50079/2016;
eingereicht: 08.02.2016.
Dissertationen (eigene und begutachtete)
S. Bernacchi:
"An axenic autotrophic and hydrogenotrophic methanogenic culture converting CO2 and H2 to CH4 within a biological methane production (CO2-BMP) process proposed as a model platform for studying gas converting bioprocesses";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, C. Paulik, C. Pfeifer;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Rigorosum: 20.04.2018.
D. Borchert:
"Data Science Methods to Decrease Experimental Efforts in Quality by Design Tasks";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, O. Spadiut, P. Filzmoser, N. Kockmann;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2020;
Rigorosum: 15.09.2020.
M. Brunner:
"A scale-down approach to assess scale-up induced process variability in mammalian cell culture";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, P. Neubauer, G. Striedner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Rigorosum: 31.08.2017.
S. Capone:
"Different approaches to make Pichia pastoris a more verstile expression platform - process, strain and product engineering";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, D. Mattanovich;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Rigorosum: 11.12.2015.
C. Dietzsch:
"Protein expression in Pichia pastoris - A novel strategy for fast bioprocess development";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, D. Haltrich;
Institut für Verfahrenstechnik,Umwelttechnik und Techn. Biowissenschaften,
2012;
Rigorosum: 23.03.2012.
D. Ehgartner:
"A Comprehensive Analytical and Process-Technological Toolbox for Improved Penicillin Production";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, R. Krull, D. Mattanovich;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Rigorosum: 24.07.2017.
A. Golabgir:
"Knowledge-oriented Bioprocess Development: from Information Mining to Model-based Monitoring and Control";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, K. Gernaey;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2016;
Rigorosum: 19.02.2016.
M. Helmel:
"Analysis of fungi (Penicillium chrysogenum and mildew) by intact cell mass spectrometry and proteomics";
Betreuer/in(nen), Begutachter/in(nen): G. Allmaier, E. Razzazi-Fazeli, C. Herwig;
Institut für Chemische Technologien und Analytik,
2014;
Rigorosum: 28.05.2014.
A. Hofer:
"A systematic approach to unravel the impact of complex raw material on biopharmaceutical processes";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, J. Lohninger, W. van Gulik;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Rigorosum: 18.04.2018.
M. Jazini:
"Multiple dynamic process modes for development and characterization of bioprocesses";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, P. Neubauer;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2013;
Rigorosum: 06.09.2013.
J. Kager:
"The Deployment of Mechanistic Models for Advanced Bioprocess Monitoring and Control";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, F. van der Berg, S. Jakubek;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Rigorosum: 07.06.2019.
D. Kamravamanesh:
"A quantitative, time-resolved approachto bioprocess understanding for the economic production of polyhydroxyalkanoate";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, C. Paulik, A. Witte;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Rigorosum: 14.03.2019.
C. Koch:
"Advances in Bioprocess Monitoring by Mid-Infrared Spectroscopy";
Betreuer/in(nen), Begutachter/in(nen): B. Lendl, C. Herwig, R. Kessler;
Chemische Technologien und Analytik,
2015;
Rigorosum: 03.12.2015.
Zusätzliche Informationen
V. Konakovsky:
"Robust and Predictable Mammalian Cell Culture Bioprocesses";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, G. Striedner, N Borth;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Rigorosum: 17.01.2017.
J. Kopp:
"Processing tools and methods to enable continuous biomanufacturing for recombinat protein production with E.coli";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, C. Peterbauer, F. Delvigne;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2020;
Rigorosum: 25.08.2020.
P. Kroll:
"Model-based methods as tools for targeted process design";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, R. Pörtner, N Borth;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Rigorosum: 27.11.2017.
B. Lorantfy:
"Quantitative Bioprocess Development with Extreme Halophilic Microorganisms for Waste to Value Applications";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, C. Posten;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2014;
Rigorosum: 05.09.2014.
N. Mahler:
"A scalable platform bioprocess for the utilization of extreme halophilic organisms in circular economy";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, A. Steinbüchel, A. Witte;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Rigorosum: 20.04.2018.
E. Martinez Porqueras:
"Characterization of biological systems for biofuels production based on physiological key parameters";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, C. Syldatk;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2014;
Rigorosum: 16.05.2014.
K. Novak:
"Development of a two-step bioprocess for CO2 fixation from industrial flue gas and production of a fuel chemical";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, S. Pflügl, D. Mattanovich, B. Blombach;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2021;
Rigorosum: 08.01.2021.
K. Paul:
"Process models for CHO bioprocess optimization and scale-up";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, P. Neubauer, G. Striedner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2020;
Rigorosum: 10.09.2020.
A. Posch:
"Science-based bioprocess design for filamentous fungi - Novel tools for efficient morphological and physiological bioprocess characterization";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, W. Burgstaller;
Institut für Verfahrenstechnik,Umwelttechnik und Technische Biowissenschaften,
2013;
Rigorosum: 11.01.2013.
W. Reichelt:
"Increased information to effort ratio through physiological bioprocess development";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, P. Neubauer;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2016;
Rigorosum: 23.08.2016.
S. Rittmann:
"Bioprocess development and quantitative analysis of biomethane production and dark fermentative biohydrogen production";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, R. Thauer;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2013;
Rigorosum: 05.04.2013.
P. Sagmeister:
"Platform Oriented Process Design Using Novel Combinatory Methods";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, A. Rathore;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2014;
Rigorosum: 12.12.2014.
A. Seifert:
"Quantitative Process Development for Biological Methane Production from Gaseous Substrates using Methanogenic Archaea";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, K. Friehs;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2013;
Rigorosum: 06.06.2013.
P. Sinner:
"Model-guided analysis and design of Corynebacterium glutamicum bioprocesses utilizing spent sulfite liquor";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, K. Gernaey, S. Papadokonstantakis;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2021;
Rigorosum: 10.08.2021.
C. Slouka:
"Custom made Inclusion Bodies: Effects on Quality Attributes by Variation of Critical Process Parameters and Control Strategies";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, B. Lendl, E. Garcia-Fruitos;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Rigorosum: 14.12.2018.
V. Steinwandter:
"Data Science Essentials for Digital Biopharma";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, O. Spadiut, L. Urbas, J. Lohninger;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Rigorosum: 18.06.2019.
S. Ulonska:
"Workflows as enablers for the use of mechanistic models in bioprocess technology";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, F. Rattay, F. Delvigne;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Rigorosum: 19.04.2018.
L. Veiter:
"Morphological PAT tools for filamentous bioprocesses - monitoring and control enhanced for fungal morphology";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, R. Krull, C. Peterbauer;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Rigorosum: 28.11.2019.
P. Wechselberger:
"Real-time Characterization of Bioprocesses";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, A. Lübbert;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2012;
Rigorosum: 26.06.2012.
M. Weissgram:
"Elucidating The Potential Of Bioprocesses On Spent Industrial Pulping Streams";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, M. Sauer;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2016;
Rigorosum: 12.01.2016.
T. Zahel:
"Data Science Workflows for Biopharmaceutical Manufacturing Process Validation Stage 1";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, P. Filzmoser, G. Cornelissen;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Rigorosum: 14.02.2018.
D. Zalai:
"A Quality by Design Approach for Enhanced Process Understanding in Biopharmaceutical Process Development";
Betreuer/in(nen), Begutachter/in(nen): C. Herwig, T. Noll;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Rigorosum: 18.12.2015.
Diplom- und Master-Arbeiten (eigene und betreute)
V. Berezhinskiy:
"Comparison of different model-based observers for monitoring substrate and product concentrations in a Penicillium chrysogenum Fed-batch process";
Betreuer/in(nen): C. Herwig, J. Kager;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 03.04.2019.
M. Birnstingl:
"Improving the refolding process of rhBMP-2 and development of a novel control strategy for refolding processes";
Betreuer/in(nen): C. Herwig, P. Sagmeister;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Abschlussprüfung: 27.04.2015.
K. Blutsch:
"Methods for monitoring CHAPS-assisted refolding and diafiltration of recombinant protein";
Betreuer/in(nen): C. Herwig, A. Meitz;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Abschlussprüfung: 29.05.2015.
G. Bonifert:
"Glyco-engineered horseradish peroxidase for targeted cancer treatment";
Betreuer/in(nen): O. Spadiut, C. Herwig;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Abschlussprüfung: 29.06.2015.
K. Denk:
"Process development for the integrated and CO2-neutral production of Bio-ethanol and Bio-methane";
Betreuer/in(nen): C. Herwig;
Inst. für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften,
2011.
P. Deringer:
"Construction of a Corrosion-Resistant 15 L-Pilot-Bioreactor for the Cultivation of Extremely Halophilic Microorganisms";
Betreuer/in(nen): C. Herwig, N. Mahler;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2016;
Abschlussprüfung: 23.06.2016.
P. Doppler:
"Large‐Scale pH Heterogeneities and Accumulated CO2 ‐ Investigating their Impact on CHO Cells with Small‐Scale Systems";
Betreuer/in(nen): C. Herwig, K. Brunner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 28.09.2017.
M. Frank:
"Development of a µ-control strategy for filamentous fungi based on viable biomass measurement";
Betreuer/in(nen): C. Herwig, D. Ehgartner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 09.01.2017.
R. Friedberg:
"Metabolic profiling of NK92 cells during dynamic small scale culturing";
Betreuer/in(nen): C. Herwig, B. Kozma;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2021;
Abschlussprüfung: 07.04.2021.
F. Fuhrmann:
"Application of Model-based Redesign of Experiments for Reactor Characterization";
Betreuer/in(nen): C. Herwig, P. Kroll;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Abschlussprüfung: 20.06.2018.
M. Garcia-Torreiro:
"Methodology to provoke biomass composition changes and its quantification using on-line measurement techniques";
Betreuer/in(nen): C. Herwig, D. Rial;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2009;
Abschlussprüfung: 29.05.2009.
Y. Gruber:
"Data analysis for increased process understanding in fermentation development";
Betreuer/in(nen): C. Neusüß, C. Herwig;
Inst. für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften,
2010.
T. Gundinger:
"An integrated comparative approach to produce horseradish peroxidase in Escherichia coli";
Betreuer/in(nen): O. Spadiut, C. Herwig;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Abschlussprüfung: 14.09.2015.
J. Gutmann:
"Quantitative analysis of bacteriocin in microbial cultivation supernatants";
Betreuer/in(nen): C. Herwig, P. Sinner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2020;
Abschlussprüfung: 23.10.2020.
T. Hartmann:
"Infuence oft he growth rate on the specific penicillin production rate during fermentation with the filamentous fungus Penicillin chrysogenum";
Betreuer/in(nen): C. Herwig, D. Ehgartner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 24.04.2019.
S. Hauer:
"Investigation of the Effect of Complex Raw Materials using Metabolic Flux Balancing - A Case Study on Penicillin Fermentation";
Betreuer/in(nen): C. Herwig;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2020;
Abschlussprüfung: 10.07.2020.
J. Kager:
"Physiological Bioprocess Control: Constant specific substrate uptake rate in an antibody producing E. coli expression platform";
Betreuer/in(nen): C. Herwig, W. Reichelt;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Abschlussprüfung: 05.10.2015.
A. Kaineder:
"High throughout inclusion body sizing and closed loop physiological process control";
Betreuer/in(nen): C. Herwig;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 31.01.2019.
A. Khorosheva:
"Extraction process for isolation of Spirulina derived components applicable as innovative healthcare products";
Betreuer/in(nen): C. Herwig, S. Pflügl;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2021;
Abschlussprüfung: 05.07.2021.
S. Kittler:
"Optimization of a cascaded continuous cultivation mode using a Design of Experiment approach";
Betreuer/in(nen): C. Herwig, J. Kopp;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 06.11.2019.
S. Kofler:
"Feed optimization of a cell culture fed-batch process using a mechanistic model";
Betreuer/in(nen): C. Herwig;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2020;
Abschlussprüfung: 20.04.2020.
A. Kolkmann:
"Verbesserung der kontinuierlichen Produktion von Einschlusskörpern in E. coli BL21 (DE3)";
Betreuer/in(nen): J. Büchs, C. Herwig;
Lehrstuhl für Bioverfahrenstechnik, RWTH Aachen University & Technische Universität Wien,
2018;
Abschlussprüfung: 04.10.2018.
J. Kopp:
"Challenging the metabolic burden of E. coli Bl21(De3)[Npro] and Bl21(De3)[pet30a]";
Betreuer/in(nen): C. Herwig, C. Slouka;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 12.09.2017.
F. Kovacs:
"Quantification of Arbuscular Mycorrhizal Fungi (AMF) Biomass in Hairy Root Production Systems";
Betreuer/in(nen): C. Herwig;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 07.11.2019.
M. Krampl:
"Using several rounds of mutations to improve sustainable Poly-β-hydroxybutyrate production in cyanobacteria";
Betreuer/in(nen): C. Herwig, S. Pflügl, M. Plesko;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018.
B. Kreppel:
"Establishing of an equivalent process platform for P. pastoris fermentation in different scales";
Betreuer/in(nen): C. Herwig;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Abschlussprüfung: 23.05.2018.
K. Lagoda:
"Bioprocess Control utilising Alternative Specific Rates";
Betreuer/in(nen): C. Herwig, J. Kager, D. Wibbing;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2021;
Abschlussprüfung: 25.01.2021.
L. Lederbauer:
"Characterizing influences of specific miRNAs on phenotypic properties of mammalian cells";
Betreuer/in(nen): C. Herwig;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 11.04.2017.
L. Marschall:
"Expression Tuning in E. coli: Discussion of state-of-the art technologies and multivariate investigation oft he pBAD mixed feed system";
Betreuer/in(nen): C. Herwig, P. Sagmeister;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2016;
Abschlussprüfung: 17.11.2016.
L. Mayer:
"Development of a platform methodology to purify recombinant glycoproteins from yeast";
Betreuer/in(nen): C. Herwig, O. Spadiut;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 26.01.2017.
B. Mitic:
"Development of a two-compartment system to model pH-inhomogeneities occurring in large-scale bioreactors";
Betreuer/in(nen): C. Herwig, K. Paul;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 19.07.2019.
R. Morales Medina:
"On-line Gas Chromatography Application in Escherichia Coli Cultures for Acetate Measurements";
Betreuer/in(nen): C. Herwig, P. Wechselberger;
Inst. für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften,
2010.
J. Moser:
"Development of an intracellular pH measuring method and subsequent application in a CHO batch fermentation process";
Betreuer/in(nen): C. Herwig, M. Brunner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2016;
Abschlussprüfung: 13.07.2016.
F. Niederberger:
"Characterization of an acetogenic industrial flue gas fermentation process with Acetobacterium woodii";
Betreuer/in(nen): C. Herwig, S. Pflügl;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 24.10.2017.
A. Pansy:
"Investigation of the influence of large scale occurring pH heterogeneities on CHO cells";
Betreuer/in(nen): C. Herwig, M. Brunner, K. Paul;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Abschlussprüfung: 15.02.2018.
A. Pekarsky:
"Influence of heterogeneities on bioprocess performance - An empirical study on scale - up predictions";
Betreuer/in(nen): C. Herwig, J. Fricke;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 11.05.2017.
F. Pilz:
"Online biomass estimation via a robust soft sensor";
Betreuer/in(nen): C. Herwig, P. Kroll;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 30.01.2019.
P. Ruschitzka:
"Process intensification by industrial brine treatment with extreme halophiles in laboratory scale";
Betreuer/in(nen): C. Herwig, B. Lorantfy;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Abschlussprüfung: 29.01.2015.
P. Sagmeister:
"Quality by Design for Process Understanding";
Betreuer/in(nen): C. Herwig, P. Wechselberger;
Inst. für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften,
2011.
G. Scherfler:
"Generation of Optimal Sampling Schedules for an Escherichia coli Fed-batch Process with a Modular Automated Sampling System";
Betreuer/in(nen): C. Herwig, S. Daume;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 27.11.2019.
K. Schiller:
"Model-assisted optimization of a recombinant Corynebacterium glutamicum bioprocess";
Betreuer/in(nen): C. Herwig, D. Mattanovich, P. Sinner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2020;
Abschlussprüfung: 20.11.2020.
C. Schimek:
"Tunable recombinant protein production with E. coli in a mixed feed environment";
Betreuer/in(nen): C. Herwig, B. Lendl;
Verfahrenstechnik, Umwelttechnik und technische Biowissenschaften,
2013;
Abschlussprüfung: 06.09.2013.
A. Schröder:
"A novel tool to determine spore inoculum quality in filamentous bioprocesses using multiparametric flow cytometry";
Betreuer/in(nen): C. Herwig, D. Ehgartner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 27.02.2017.
J. Schulze:
"Quantitative Comparison of Recombinant Pichia pastoris MutS Strains by Specific Parameters Deriving from Dynamic Process Conditions";
Betreuer/in(nen): T. Bley, C. Herwig, C. Dietzsch;
TU - Dresden,
2011.
N. Seidl:
"Investigation of physiological response of CHOcell to pH shifts during a batch fermentation process";
Betreuer/in(nen): C. Herwig, M. Brunner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2017;
Abschlussprüfung: 17.11.2017.
A. Seifert:
"Transient fermentation experiments to analyze mixed substrate dynamics in Pichia pastoris";
Betreuer/in(nen): C. Herwig;
Inst. für Verfahrenstechnik, Umwelttechnik und Techn. Biowissenschaften,
2011.
B. Seyer:
"Impact of process parameters on morphology,physiology and process performance oft he filamentous funfus Penicillium chrysogenum";
Betreuer/in(nen): C. Herwig, D. Ehgartner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2015;
Abschlussprüfung: 15.06.2015.
L. Sidarenka:
"Monitoring of Corynebacterium glutamicum cultivations by means of a genetically encoded fluorescence sensor";
Betreuer/in(nen): C. Herwig, P. Sinner;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2019;
Abschlussprüfung: 09.12.2019.
A. Tuveri:
"Model Based Control of Penicillium Chrysogenum Fed-Batch Process";
Betreuer/in(nen): C. Herwig, J. Kager, S. Tronci;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Abschlussprüfung: 25.09.2018.
E. Ullmann:
"Investigating the NADH enzyme library of the extremophile Methanothermobacter marburgensis as a potential tool for synthetic biology";
Betreuer/in(nen): C. Herwig, O. Spadiut;
Institut für Verfahrenstechnik,Umwelttechnik und Technische Biowissenschaften,
2013;
Abschlussprüfung: 18.06.2013.
D. Waldschitz:
"Model development and comparison of mechanistic models for E. coli to allow for model predictive control";
Betreuer/in(nen): C. Herwig, S. Ulonska;
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften,
2018;
Abschlussprüfung: 03.09.2018.
Wissenschaftliche Berichte
C. Herwig:
"Analyse der Auswirkung der Signalqualität auf die Prozessperformance";
Bericht für Innovatis AG;
2009;
20 S.
C. Herwig:
"Jahresberichte der AKs - AK Prozessanalytik";
Bericht für Gesellschaft Deutscher Chemiker;
Berichts-Nr. Mitteilungsblatt 1/2018,
2018;
4 S.
M. Jazini, S. Rittmann, C. Herwig:
"Qualitative study on biological TOC reduction in brine";
Bericht für UHDE;
2012;
35 S.
M. Jazini, P. Wechselberger, P. Sagmeister, C. Herwig:
"Mathematical formulation of the module of oxidative metabolism";
Bericht für Siemens;
2012;
24 S.
M. Jazini, P. Wechselberger, P. Sagmeister, C. Herwig:
"Studie Softsensoren für Bioreaktoren auf Basis von Bilanzgleichungen (Final Project Report)";
Bericht für Siemens;
2012;
51 S.
J. Kager, J. Fricke, U. Becken, C. Herwig:
"A Generic Biomass Soft Sensor and Its Application in Bioprocess Development";
Bericht für Eppendorf AG;
Berichts-Nr. 357,
2017;
8 S.
J. Kager, C. Herwig, R. Holzer:
"imPACts Industrial Methods for Process Analytical Chemistry - From Measurement Technologies to Information Systems - "All-in-One: ein neuer Blick auf biochemische Prozesse"!";
Bericht für imPACts;
2017;
2 S.
J. Kager, P. Sinner, H. Müller, C. Herwig:
"Real-time estimation of fungal biomass based on off gas analysis";
Bericht für BlueSens GmbH;
2019;
4 S.
K. Kandra, P. Kroll, M. Brunner, P. Wechselberger, C. Herwig:
"Online Monitoring of CHO Cell Culture";
Bericht für Hamilton Company;
2014;
2 S.
C. Koch, A. Posch, B. Lendl, C. Herwig:
"Proof of Concept US-FTIR for Filamentous Fungi";
Bericht für Sandoz AG;
2012.
A. Schneider, C. Herwig, J. Cardoso de Menezes, F. Schneider, M. de Grutter, M. Dittmer, M. Voss, V. Rosha:
"Implementing Knowledge Management in Bioprocesses : A QbD Driven Approach Turning Data into Knowledge in Reference to the CMC A-Mab Case Study";
Bericht für ISPE;
2012;
24 S.
O. Spadiut, C. Herwig:
"Analyse Proteinstabilität durch Pufferkomponenten";
Bericht für ILK Dresden;
2010.
O. Spadiut, C. Herwig:
"Erzeugung und gegenwärtige Abfüllungs- und Einfriertechnologie von Proteinlösungen aus biotechnologischer Erzeugung";
Bericht für ILK Dresden;
2010;
14 S.
O. Spadiut, C. Herwig:
"Schädigungsmechanismen von Proteinen";
Bericht für ILK Dresden;
2010;
10 S.
