[Zurück]

B. Devcic-Kuhar, S. Pfaffenberger, L. Gherardini, M. Gröschl, E. Benes, J. Wojta, M. Gottsauner-Wolf:
"Ultrasound enhanced thrombolysis";
in: "Proc. 1st Congress of Alps Adria Acoustics Association / 3rd Congress of Slovenian Acoustical Society", M. Cudina (Hrg.); Slovenian Acoustical Society, Portoroz/Slowenien, 2003, (eingeladen), ISBN: 961-6238-73-6, S. 75 - 88.

Thrombotic occlusion of the coronary artery results in myocardial infarction, one of the major
causes of death in the western world. Also, acute peripheral occlusions leading to limb
ischemia are a severe clinical problem requiring immediate thrombolytic therapy. The most
powerful blood clot dissolver yet known is the fibrin-selective recombinant tissue
plasminogen activator (rt-PA). However, penetration of rt-PA from the surrounding blood
into the thrombus is a very slow process and a rate-limiting step in reestablishment of blood
flow and maintenance of viability of the affected region, but it can be enforced by taking
place in an ultrasound field (sonothrombolysis). In our four-years research on
sonothrombolysis, we studied the effects on thrombolysis enhancement of ultrasound of
therapeutic quality, which is commonly and safely used in physical therapy. We also
developed a new method of visual detection of fibrinolytic reactants within the blood clot.
This method enabled us to localize fibrinolytic components in the thrombus and to study the
effect of ultrasound on their spatial distribution. We have shown for the first time that
ultrasound facilitates the access of rt-PA to the deeper layers of the clot, thus leading to
significantly faster clot dissolution.

http://aleph.ub.tuwien.ac.at/F?base=tuw01&func=find-c&ccl_term=AC04405878