[Back]


Publications in Scientific Journals:

S. Pfaffenberger, B. Devcic-Kuhar, C. Kollmann, S.P. Kastl, C. Kaun, W.S. Speidl, T.W. Weiss, S. Demyanets, R. Ullrich, H. Sochor, C. Wöber, J. Zeitlhofer, K. Huber, M. Gröschl, E. Benes, G. Maurer, J. Wojta, M. Gottsauner-Wolf:
"Can a Commercial Diagnostic Ultrasound Device Accelerate Thrombolysis ?: An In Vitro Skull Model";
Stroke, 36 (2005), 124 - 128.



English abstract:
Background and Purpose: Recently 3 clinical trials revealed encouraging results in recanalization and clinical outcome in acute stroke patients when 2 MHz transcranial Doppler monitoring was applied. This study investigated whether a 1.8-MHz commercial diagnostic ultrasound device has the potential to facilitate thrombolysis using an in vitro stroke model.
Methods: Duplex-Doppler, continuous wave-Doppler and pulsed wave(PW)-Doppler were compared on their impact on recombinant tissue plasminogen activator (rt-PA)-mediated thrombolysis. Blood clots were transtemporally sonicated in a human stroke model. Furthermore, ultrasound attenuation of 5 temporal bones of different thicknesses was determined.
Results: In comparison only significantly PW-Doppler accelerated rt-PA-mediated thrombolysis significantly. Without temporal bone, PW-Doppler plus rt-PA showed a significant enhancement in relative clot weight loss of 23.7% when compared to clots treated with rt-PA only (33.9%5.5% versus 27.4%5.2%; P<0.0005). Ultrasound attenuation measurements revealed decreases of the output intensity of 86.8% (8.8dB) up to 99.2% (21.2dB) depending on temporal bone thicknesses (1.91 to 5.01mm).
Conclusion: Without temporal bone, PW-Doppler significantly enhanced thrombolysis.. However, because of a high attenuation of ultrasound by temporal bone, no thrombolytic effect was observed in our in vitro model, although Doppler imaging through the same temporal bone was still possible.


Online library catalogue of the TU Vienna:
http://aleph.ub.tuwien.ac.at/F?base=tuw01&func=find-c&ccl_term=AC05937965


Created from the Publication Database of the Vienna University of Technology.