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B. Devcic-Kuhar:
"Mechanisms and Effects of Ultrasound-Enforced Transport of Drugs through Biological Barriers";
Vortrag: 2nd Congress of Alps-Adria Acoustics Association, Opatija / Croatia (eingeladen); 23.06.2005 - 24.06.2005; in: "Proc. 2nd Congress of Alps-Adria Acoustics Association", (2005), ISBN: 953-95097-0-x; S. 4 - 13.

Most pharmacological compounds that are used in drug therapy, on their way to the target sites, meet biological interface barriers such as cell membrane or fibrin network. Very often, only small portions of administered drugs overcome these barriers. Ultrasound has the ability to change the permeability of biological barriers and to accelerate transport of drugs, genes, and other therapeutic compounds through them. Permeability of cell membranes increases due to a temporary and reversible creation of pores in the bi-layer membrane structure, an effect which makes the entrance of pharmacological compounds into the cells much easier. The size of the created pores has not been determined, up to now. Ultrasound also facilitates the access of thrombolytic agent to the deeper layers of the clot, thus leading to significantly faster clot dissolution. Understanding of the basic mechanisms involved in the phenomenon of increased permeability of biological interfaces is a prerequisite to the controlled ultrasound-mediated drug delivery. Our work is aimed to give more insight into the ultrasound-triggered effects on cell membrane and fibrin network on a sub-microscopic level and to establish the link between the observed effects of ultrasound and the ultrasound mechanisms that cause these effects.

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