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B. Ostachowicz, M. Lankosz, B. Tomik, D. Adamek, P. Wobrauschek, C. Streli, P. Kregsamer:
"Analysis of some chosen elements of cerebrospinal fluid and serum in amyotrophic lateral sclerosis patients by total reflection X-ray fluorescence";
Spectrochimica Acta Part B, 61 (2006), 1210 - 1213.

Trace elements play an important role in the human central nervous system. Significant variations of the concentration of trace elements in
body fluids may occur in neurodegenerative diseases. In the present work an investigation of the elemental composition of the serum, and the
cerebrospinal fluid in amyotrophic lateral sclerosis patients and a control group was performed.
For the analysis of the body fluids Total reflection X-ray Fluorescence (TXRF) spectrometry was used. The samples were taken during routine
diagnostic procedures. Na, Mg, Cl, K, Ca, Cu, Zn, and Br were determined in both fluids. In order to validate the results of analysis a serum
standard reference material was measured. A t-test was applied to check if the mean concentrations of the elements are different for ALS and the
control group. For the serum samples higher values for Br were found in the ALS group, for the cerebrospinal fluid lower values of Na, Mg and Zn as well as higher Ca values were found in the ALS group compared to the control group.
© 2006 Elsevier B.V. All rights reserved.

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