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Zeitschriftenartikel:

L. Czollner, W. Frantsits, B. Küenburg, U. Hedenig, J. Fröhlich, U. Jordis:
"New kilogram-synthesis of the Anti-Alzheimer drug (-)-galanthamine";
Tetrahedron Letters, 39 (15) (1998), S. 2087 - 2088.



Kurzfassung englisch:
A concise, scalable synthesis of (-)-galanthamine, a drug being used for the treatment of Alzheimer's disease, is described. The yield of the crit. phenolic coupling step of I was optimized to 45-50%. For the redn. of the aryl bromide, air-activated LiAlH4 was used and racemic narwedine was converted to (-)-narwedine by a second order asym. transformation.
AN 1998:233586

Erstellt aus der Publikationsdatenbank der Technischen Universitšt Wien.