Publications in Scientific Journals:
L. Czollner, W. Frantsits, B. Küenburg, U. Hedenig, J. Fröhlich, U. Jordis:
"New kilogram-synthesis of the Anti-Alzheimer drug (-)-galanthamine";
Tetrahedron Letters,
39 (15)
(1998),
2087
- 2088.
English abstract:
A concise, scalable synthesis of (-)-galanthamine, a drug being used for the treatment of Alzheimer's disease, is described. The yield of the crit. phenolic coupling step of I was optimized to 45-50%. For the redn. of the aryl bromide, air-activated LiAlH4 was used and racemic narwedine was converted to (-)-narwedine by a second order asym. transformation.
AN 1998:233586
Created from the Publication Database of the Vienna University of Technology.