[Zurück]

F. Sauter, U. Jordis, J. Fröhlich, K. Gewald, F. Grohmann, E. Ahmed:
"Synthesis of fully aromatic pyrido[4',3':4,5]thieno[2,3-d]pyrimidine derivatives";
ACH - Models in Chemistry, 131 (3-4) (1994), S. 489 - 498.

Reaction of N-protected 4-piperidones with sulfur and cyanacetamide gave thieno[2,3-c]pyridine derivs. which were cyclized to tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidines. Subsequently, the pyrido moiety of these products was aromatized. The products thus obtained were used to prep. pyrido[4',3':4,5]thieno[2,3-d]pyrimidine-4-amines, e.g. I.
AN 1995:256137