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Zeitschriftenartikel:

P Hinsmann, L. Arce, P. Svasek, M. Lämmerhofer, B. Lendl:
"Separation and on-line distinction of enantiomers - A non-aqueous capillary electrophoresis Fourier transform infrared spectroscopy study";
Applied Spectroscopy, 58 (2004), S. 662 - 667.



Kurzfassung englisch:
We report on the separation and on-line distinction of (R,S)-3-5-dinitrobenzoyl leucine (DNB-Leu) enantiomers with non-aqueous capillary electrophoresis (CE) and Fourier transform infrared spectroscopic (FT-IR) detection using O-(tert-butyl carbamoyl) quinine (tBuCQN) as chiral selector (CS). Due to intermolecular interactions - particularly ionic interactions, hydrogen bonding and p-p-interactions - the enantiomers undergo enantioselective complex and ion-pair formation, respectively with the CS enabling CE separation and direct identification with FT-IR detection. Especially the S-enantiomer of the analyte shows significant changes in the mid-IR region upon complexation allowing for a clear spectral distinction between both enantiomers. In that way FT-IR spectroscopy represents a novel attractive detection method for CE enantiomeric separations providing stereochemical information on the interactions between the chiral selector and the enantiomers, which is hardly accessible by other CE detection methods.


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