[Zurück]

U. Jordis, B. Küenburg:
"Chiral bridged piperazines: synthesis of (1S,4S)-2,5-diazabicyclo[2.2.2]octane";
in: "Electronic Conference on Heterocyclic Chemistry-Proceedings", herausgegeben von: Electronic Conference on Heterocyclic Chemistry (ECHET96); Electronic Conference on Heterocyclic Chemistry (ECHET96), 1997, ISBN: 0-85404-894-4.

In the course of the synthesis of quinolone carboxylic acids as potential antibacterials we were interested in conformationally fixed, bridged piperazines. In addition to the formally methylene bridged piperazines (1R,4R)- and (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes, [2] we developed a synthesis of the formally ethylene bridged piperazine, the title compound (8), starting from N-Cbz-glycine succinimide ester and L-homoserine lactone.

http://aleph.ub.tuwien.ac.at/F?base=tuw01&func=find-c&ccl_term=AC05937036

http://www.ch.ic.ac.uk/ectoc/echet96/