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M. Schuster, C. Turecek, M. Rumpler, F. Varga, R. Liska, J. Stampfl:
"Development of Photopolymerizable Biopolymers for Rapid Prototyping of Cellular Bone Replacement Materials";
Poster: EuroMat 2005, Prag, Tschechien; 09-05-2005 - 09-06-2005; in: "Euromat 2005 European Congress on Advanced Materials and Processes http.//www.Euromat2005.fems.org", (2005), 1 pages.

The most important characteristics of bone replacement materials are
biocompatibility and bioresorbability. To achieve these characteristics
the material must support the attachment, multiplication and
differentiation of osteogenic cells. These properties are related to
the functional groups in the monomers present e.g.
oligoethyleneglycole, urethane-, hydroxy-, carboxy- or phosphonic
groups.

In this investigation, reactivity and biocompatibility of different
types of commercially available mono- and polyfunctional monomers and
photoinitiators were determined. Additionally, series of
multifunctional methacrylates based on hydrolyzed gelatine and
blockcopolymers of lactic acid were prepared. Biocompatibility tests
were performed using MC3T3-E1 osteoblast like cells. The main goals of
these investigations were to obtain liquid and/or excellently soluble
derivatives.

The results show that some of the synthesized resins were biocompatible
and applicable to the fabrication of scaffolds by thermal polymerization in
water-soluble mould materials prepared by 3D-photoshaping using rapid
prototyping to obtain arbitrary structures. Additionally, direct
photoprinting of scaffolds using rapid prototyping will be presented.

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