[Zurück]

M. López Pastor, A. Domínguez-Vidal, M.J. Ayora-Cañada, T. Laurell, M. Valcárcel, B. Lendl:
"Containerless reaction monitoring in ionic liquids by means of Raman microspectroscopy";
Lab on a Chip, 7 (2007), S. 126 - 132.

Reaction monitoring by Raman microspectroscopy in levitated room temperature ionic liquid
(RTIL) droplets is reported. Due to their non-volatility, RTIL droplets are well-suited to act
as wall-less microreactors. The droplets were produced by a piezoelectric flow-through
microdispenser connected to an automated flow injection system and were levitated by an acoustic
trap. Taking advantage of the flow system versatility, the sequence of reagents was easily changed
to study a model organic reaction: the Knoevenagel condensation. The reaction was followed by
Raman microspectrometry and the obtained spectra were analysed using multivariate curve
resolution to retrieve the concentration profiles and pure spectra of reactants, intermediates and
products involved in the reaction. In addition, information about solvation interactions was
obtained by monitoring the desolvation process taking place when a volatile co-solvent
evaporated from the droplet.