Zeitschriftenartikel:
D. Lumpi, C. Braunshier, C. Hametner, E. Horkel, B. Zachhuber, B. Lendl, J. Fröhlich:
"Convenient multigram synthesis of monodisperse oligo(ethylene glycols): effective reaction monitoring by infrared spectroscopy using an attenuated total reflection fibre optic probe";
Tetrahedron Letters,
50
(2009),
47;
S. 6469
- 6471.
Kurzfassung englisch:
A convenient approach for the synthesis of monodisperse oligo(ethylene glycols) up to 12 units is
described. A novel cleavage protocol replacing laborious hydrogenolysis is introduced to achieve a fast,
inexpensive and widely applicable procedure. In addition to the synthetic part, Fourier transform infrared
(FTIR) spectroscopy using a fibre optic attenuated total reflection (ATR) sensor was applied to monitor the
formation of sensitive key intermediates, resulting in optimized reaction times. By applying this in-line
technique, the possibility of real-time analysis under inert conditions was impressively demonstrated.
Schlagworte:
Monodisperse OEG PEG, Trityl cleavage, Oligo(ethylene glycols), In situ reaction monitoring, ATR-IR-sensor spectroscopy
"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.1016/j.tetlet.2009.09.010
Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.