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L. Alzubaidi, W. Mohl, F. Rattay:
"Automatic computation for pressure controlled intermittent coronary sinus occlusion";
Poster: World Congress in Computer Science, Computer Engineering and Applied Computing, Las Vegas, Nevada; 2010-07-12 - 2010-07-15; in: "Proc. World Congress in Computer Science, Computer Engineering and Applied Computing", (2010).

Pressure controlled intermittent coronary sinus
occlusion (PICSO) has been found to substantially salvage
ischemic myocardium. By elevating venous pressure two
mechanisms are involved namely the distention of venous
vessels inducing mechanotransduction as well as a
redistribution of venous flow towards ischemic areas.
Mechanotransduction in endothelial cells inducing changes in
the ischemic heart inducing myocardial salvage as well as
myocardial recovery is blunted by possible consequences of
myocardial perfusion deficits by limiting coronary inflow.
To limit these severe side effects we have evaluated a new
mathematical model to describe the Increase (Inflation) and
decrease (deflation) in coronary Sinus pressure (CSP)
following pressure controlled intermittent coronary sinus
occlusion (PICSO) and release. The model is evaluated and
compared on the basis of dogs, pigs and sheep. The model
consists of two parts with three parameter double exponential
function for each, and it was fitted by using the non-linear
least squares algorithms. The new model was used in
implementation of automatic computing module which is
responsible to compute the following quantities for Inflation
and Deflation:
1. Systolic and diastolic plateau.
2. Rise-Time of systolic and diastolic plateau.
3. The mean integral of the CSP (Area under the curve).
4. Number of heart beats impact in inflation and deflation
periods.
5. Driving the slope of CSP
Corresponding quantities for various coronary sinus balloon
inflation and deflation cycles were computed with ranging
from cycles being as short as 5sec/3sec (inflation/deflation
ratio) to cycles as long as 12sec/8sec