W. Freinbichler, M.A Colivicchi, C. Stefanini, L. Bianchi, C. Ballini, B. Misini, P. Weinberger, W. Linert, D. Vareslija, K. Tipton, L. Della Corte:
"Highly reactive oxygen species: detection, formation, and possible functions";
Cellular and Molecular Life Sciences,
The so-called reactive oxygen species (ROS) are defined as oxygen-containing species that are more reactive than O2 itself, which include hydrogen peroxide and superoxide. Although these are quite stable, they may be converted in the presence of transition metal ions, such as Fe(II), to the highly reactive oxygen species (hROS). hROS may exist as free hydroxyl radicals (HO), as bound (``crypto´´) radicals or as Fe(IV)-oxo (ferryl) species and the somewhat less reactive, non-radical species, singlet oxygen. This review outlines the processes by which hROS may be formed, their damaging potential, and the evidence that they might have signaling functions. Since our understanding of the formation and actions of hROS depends on reliable procedures for their detection, partic- ular attention is given to procedures for hROS detection and quantitation and their applicability to in vivo studies.
Ferrous iron (Fe(II)) Fenton reaction Hydroxyl radical Microdialysis Radical traps Singlet oxygen
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