[Zurück]

A. Doaa:
"Physicochemical Studies of Some Transition Metal Ions With 2-Aminothiophene-3-carboxylic Acid Derivatives";
Betreuer/in(nen), Begutachter/in(nen): W. Linert, M.M. Beckheit, N. Navar; Department of Chemistry Mansoura University/ Kairo / Egypt, 2011; Rigorosum: 31.10.2011.

Hydrazones had provoked wide interest for their significant biological
and pharmaceutical activities such as antibacterial, antiviral, antimalarial,
antileprotic and antineoplastic as well as anticancer activity. The current
interest in hydrazones is due to the presence of various donor atoms, which
exhibit diverse bonding modes leading to different structural motifs. Also,
these ligands and their complexes have displayed biological activity.
A literature survey includes transition metal complexes of some
hydrazones derived from biacetylmonoxime, salisaldehyde, thiophene
carboxaldehyde and isatin. The literature survey also includes the metal ions
uptake studies using chitosan and modified chitosan.
The ligands used in this study are biacetylmonoxime 2-amino-4,5-
pentamethylene-thiophene-3-carbohydrazone (H2BMTC), salicaldehyde 2-
amino-4,5-pentamethylene-thiophene-3-carbohydrazone (H2SATC),
thiophene carboxaldehyde 2-amino-4,5-pentamethylene-thiophene-3-
carbohydrazone (HTCTC) and isatin 2-amino-4,5-pentamethylenethiophene-
3-carbohydrazone (H2ISTC).
The procedures of preparation of the ligands (H2BMTC, H2SATC,
HTCTC and H2ISTC) and their metal complexes were described. Physical,
elemental analyses, molar conductivities, spectral (1H NMR, IR, UV-Vis and
mass) studies, magnetic measurements and thermogravimetric analysis have
been used to characterize the isolated solid complexes. In order to assess the
influences of the structural properties of the ligands and the type of the metal
on thermal behavior of the complexes, the order (n) and the heat of
activation (Ea) of the various decomposition stages are determined from the
TG and DTG using the Coats-Redfern and Horowitz-Metzger methods. This
section includes also the determination of the thermodynamic parameters of
activation (ΔH, ΔS and ΔG) which can be calculated by Erying equation.
SUMMARY______________________________________________________________
(252)
Antimicrobial activity of the investigated ligands and their metal
complexes were tested.
The study also includes metal uptake of some metal ions using
modified chitosan resin using our hydrazide (2-amino-4,5-pentamethylenethiophene-
3-carboxylic acid hydrazide) and modified magnetic chitosan
resin using bis Schiff base derived from condensation of 2-amino-4,5-
pentamethylene-thiophene-3-carboxylic acid hydrazide and glyoxal. The
procedures of preparation of modified chitosan resin using 2-amino-4,5-
pentamethylene-thiophene-3-carboxylic acid hydrazide and modified
magnetic chitosan resin using bis Schiff base derived from condensation of
2-amino-4,5-pentamethylene-thiophene-3-carboxylic acid hydrazide and
glyoxal were reported. The resins were characterized on the basis of IR
spectral studies, electron scanning microscope and powder X-ray diffraction
analysis. The adsorption properties of the resins toward some metal ions
were evaluated. Various factors affecting the uptake behavior such as pH,
temperature, contact time and initial concentration of the metal ions were
investigated.