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T. Weber, S. Wassertheurer, M. Rammer, E. Maurer, B. Hametner, C. Mayer, J. Kropf, B. Eber:
"Validation of a Brachial Cuff-Based Method for Estimating Central Systolic Blood Pressure";
Hypertension, 11 (2011), 825 - 832.

Abstract-The prognostic value of central systolic blood pressure has been established recently. At present, its noninvasive
assessment is limited by the need of dedicated equipment and trained operators. Moreover, ambulatory and home blood
pressure monitoring of central pressures are not feasible. An algorithm enabling conventional automated oscillometric
blood pressure monitors to assess central systolic pressure could be of value. We compared central systolic pressure,
calculated with a transfer-function like method (ARCSolver algorithm), using waveforms recorded with a regular
oscillometric cuff suitable for ambulatory measurements, with simultaneous high-fidelity invasive recordings, and with
noninvasive estimations using a validated device, operating with radial tonometry and a generalized transfer function.
Both studies revealed a good agreement between the oscillometric cuff-based central systolic pressure and the
comparator. In the invasive study, composed of 30 patients, mean difference between oscillometric cuff/ARCSolverbased
and invasive central systolic pressures was 3.0 mm Hg (SD: 6.0 mm Hg) with invasive calibration of brachial
waveforms and 3.0 mm Hg (SD: 9.5 mm Hg) with noninvasive calibration of brachial waveforms. Results were
similar when the reference method (radial tonometry/transfer function) was compared with invasive measurements. In
the noninvasive study, composed of 111 patients, mean difference between oscillometric cuff/ARCSolver- derived and
radial tonometry/transfer function- derived central systolic pressures was 0.5 mm Hg (SD: 4.7 mm Hg). In conclusion,
a novel transfer function-like algorithm, using brachial cuff-based waveform recordings, is suited to provide a realistic
estimation of central systolic pressure. (Hypertension. 2011;58:825-832.)

http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.176313