[Zurück]

M. Schön, M. Schnürch, M.D. Mihovilovic:
"Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production";
Molecular Diversity, 15 (2011), S. 639 - 643.

Dehydration of fructose and glucose in dipolar,
aprotic solvents leads to formation of 5-hydroxymethylfurfural.
Conditions for continuous flow reactions using a
cartridge-based reactor system and a stop-flow microwave
reactor were established showing very good product yields
and selectivity without the limitation of a batch process such
as upscaling and precise temperaturemonitoring and control.
A maximum product HPLC yield of 90.3% under cartridgebased
heating and 85.6% under microwave heating could be
achieved using mild and quick reaction conditions. Formation
of levulinic acid as a by-product could not be detected
under the optimized reaction conditions.

Flow chemistry · Carbohydrate dehydration · 5-Hydroxymethylfurfural · Cartridge-based reactors · Stopped-flow microwave

http://dx.doi.org/10.1007/s11030-010-9295-9