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A. Celarek, T. Kraus, E. Tschegg, S. Fischerauer, S. Tschegg, P. Uggowitzer, A. Weinberg:
"PHB, crystalline and amorphous magnesium alloys: Promising candidates for bioresorbable osteosynthesis implants?";
Materials Science & Engineering C - Materials for Biological Applications, 32 (2012), 1503 - 1510.

In this study various biodegradable materials were tested for their suitability for use in osteosynthesis implants,in particular as elastically stable intramedullary nails for fracture treatment in paediatric orthopaedics.
The materials investigated comprise polyhydroxybutyrate (PHB), which belongs to the polyester family and is produced by microorganisms, with additions of ZrO2 and a bone graft substitute; two crystalline magnesium alloys with significantly different degradation rates ZX50 (MgZnCa, fast) and WZ21 (MgYZnCa, slow);and MgZnCa bulk metallic glasses (BMG). Push-out tests were conducted after various implantation times in rat femur meta-diaphysis to evaluate the shear forces between the implant material and the bone. The most promising materials are WZ21 and BMG, which exhibit high shear forces and push-out energies. The degradation rate of ZX50 is too fast and thus the alloy does not maintain its mechanical stability long enough during the fracture-healing period. PHB exhibits insufficient mechanical properties: it degrades very slowly and the respective low shear forces and push-out energy levels are unsatisfactory.

Polyhydroxybutyric acid, PHB, Magnesium, Biodegradation, Shear, Bone healing

http://dx.doi.org/10.1016/j.msec.2012.04.032