[Zurück]

M. Oliver, J. Hernando-Garcia, A. Ababneh, H. Seidel, U. Schmid, J. Andrés, P. Pobedinskas, K. Haenen, J.L. Sànchez-Rojas:
"Resonantly excited AlN-based microcantilevers for immunosensing";
Microsystem Technologies - Micro- and Nanosystems - Information Storage and Processing Systems, 18 (2012), S. 1089 - 1094.

The purpose of this work is to study the performance
of resonantly driven microcantilevers excited with a
piezoelectric aluminium nitride thin film as a mass sensor for
the detection of interactions in the field of immunosensing.
Two cantilevers with different width (i.e. 300 and 200 lm),
but constant length and thickness of 300 and 20 lm were
considered. The figures of merit of these structures, such as
the mass sensitivity and the limit of mass detection, were
determined. According to the results obtained, a cantilever
being 300 9 200 lm2 in size and a high frequency mode
was the best combination to detect antibody/antigen interactions.
The previous combination was applied to detect the
affinity between rabbit immunoglobulin G (IgG) and the
complementary anti-rabbit IgG produced in goat. The binding
was registered as a shift of the resonance frequency of the
mode under investigation and the correlation between the
added mass and the measured shift is analysed.

The purpose of this work is to study the performance
of resonantly driven microcantilevers excited with a
piezoelectric aluminium nitride thin film as a mass sensor for
the detection of interactions in the field of immunosensing.
Two cantilevers with different width (i.e. 300 and 200 lm),
but constant length and thickness of 300 and 20 lm were
considered. The figures of merit of these structures, such as
the mass sensitivity and the limit of mass detection, were
determined. According to the results obtained, a cantilever
being 300 9 200 lm2 in size and a high frequency mode
was the best combination to detect antibody/antigen interactions.
The previous combination was applied to detect the
affinity between rabbit immunoglobulin G (IgG) and the
complementary anti-rabbit IgG produced in goat. The binding
was registered as a shift of the resonance frequency of the
mode under investigation and the correlation between the
added mass and the measured shift is analysed.

http://dx.doi.org/10.1007/s00542-012-1444-x