Publications in Scientific Journals:

N. Iqbal, F. Rudroff, A. Brige, J. van Beeumen, M.D. Mihovilovic:
"Asymmetric Bioreduction of Activated Carbon-Carbon Double Bonds Using Shewanella Yellow Enzyme (SYE-4) as Novel Enoate Reductase";
Tetrahedron, 68 (2012), 37; 7619 - 7623.

English abstract:
Shewanella yellow enzyme (SYE-4), a novel recombinant enoate reductase, was screened against a variety of different substrates bearing an activated double bond, such as unsaturated cyclic ketones, diesters, and substituted imides. Dimethyl- and ethyl esters of 2-methylmaleic acid were selectively reduced to (R)-configured succinic acid derivatives and various N-substituted maleimides furnished the desired (R)-products in up to >99% enantiomeric excess. Naturally occurring (+)-carvone was selectively reduced to (-)-cis-dihydrocarvone and (-)-carvone was converted to the diastereomeric product, respectively. Overall SYE-4 proved to be a useful biocatalyst for the selective reduction of activated C=C double bonds and complements the pool of synthetic valuable enoate reductases. (C) 2012 Elsevier Ltd. All rights reserved.

Enoate reductase; Shewanella yellow enzyme; Bioreduction; Biocatalysis

"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)

Created from the Publication Database of the Vienna University of Technology.