[Zurück]

G. Gosh, K. Misra, W. Linert, S. Moi:
"Interaction Of Glutathione with Cis-(2- Aminomethylpyridine)diaqua platinum(II) Perchlorate In Aqueous Medium: Their Kinetics And Mechanism";
Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry, 43 (2013), 6; S. 714 - 721.

The kinetic interact ion of glutathione with cis-[Pt(pic)(OH2)2](ClO4)2 (pic=2- Aminomethylpyridine) has been studied spectrophotometrically as a funct ion of cis- [Pt(pic)(OH2)2]2+, glutathione concentration and temperature at pH 4.0, where the complex exists predominant ly as the diaqua species and glutathione as a zwitter ion. The substitution react ion shows two dist inct consecut ive steps: the first is the ligand assisted anat ion and the second is the chelat ion step. The associat ion equilibr ium constant (KE) for the outer sphere complex format ion has been evaluated with rate constants k1 (≈10-3) for the first step. The activat ion parameters for both the steps were evaluated using Eyring equat ion. The low ΔH1# = (52.37 ± 2.10 kJmol-1) and large negat ive value of ΔS1 ≠ = (-112.35±2.98 JK-1mol-1) as well as ΔH2 # = (37.29 ±1.84 kJmol-1) and ΔS2 # = (-130.12 ± 3.16 JK-1mol-1) indicate an associat ive mode of act ivat ion for both the aqua ligand subst itution processes. Key words: Kinet ics and mechanism, glutathione, 2-Aminomethylpyridine, associative mechanism.

Kinetics and mechanism, glutathione, 2-Aminomethylpyridine, associative mechanism

http://dx.doi.org/10.1080/15533174.2012.754760