P. Anitha, P. Viswanathamurthi, B. Misini, W. Linert:
"Synthesis, characterization, antioxidant, cytotoxic, and DNA cleavage studies of ruthenium(III) complexes containing N-substituted thiosemicarbazone/semicarbazone";
Monatshefte für Chemie,
The synthesis, characterization, and biological studies of ruthenium(III) complexes containing ONS/ONO tridentate ligands are reported. Reactions of 1,2-naphthoquinone N-substituted thiosemicarbazone/semicarbazone (HLn; n = 1-4) with [RuCl3(EPh3)3] (E = P or As) gave [RuCl2(EPh3)(Ln)], which were characterized by elemental analysis, FT-IR, UV-Vis, magnetic susceptibility measurement, ESR spectra, ESI-MS, electrochemical studies, and powder X-ray diffraction pattern. The free radical scavenging ability, assessed by antioxidant assays involving DPPH and hydroxyl radicals, showed that the complexes possess excellent radical scavenging properties. The in vitro cytotoxicity of the complexes against MCF-7 and A431 cell lines was assayed which showed that the ruthenium(III) complexes exhibited effective cytotoxic activity against selected cancer cells. Furthermore, the complexes were found to promote the cleavage of plasmid pBR322 DNA.
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