M. Christakakou, M. Schön, M. Schnürch, M.D. Mihovilovic:
"Arylation of pyridines via Suzuki-Miyaura cross-coupling and pyridine directed C-H activation using a continuous-flow approach";
Suzuki-Miyaura cross-coupling reactions between heteroaryl
bromides and arylboronic acids were performed employing
a continuous-flow approach using a simple flow reactor designed
in-house. Pd(PPh3)4 was used as catalyst, and arylboronic acids containing both electron-withdrawing and electron-donating groups were applied. The coupling process required 23 minutes of residence
time to be completed and generally good yields were obtained.
Subsequent arylation of 2-phenyl pyridine was carried out via a C-H activation strategy using substituted bromobenzene compounds
and a ruthenium(II) catalyst. To the best of our knowledge in this work we present for the first time the possibility of performing intermolecular C-H activation in a continuous-flow system.
heterocycles, cross coupling, flow chemistry, C-H activation, catalysis
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