Zeitschriftenartikel:
M. Christakakou, M. Schön, M. Schnürch, M.D. Mihovilovic:
"Arylation of pyridines via Suzuki-Miyaura cross-coupling and pyridine directed C-H activation using a continuous-flow approach";
Synlett,
2013
(2013),
24;
S. 2411
- 2418.
Kurzfassung englisch:
Suzuki-Miyaura cross-coupling reactions between heteroaryl
bromides and arylboronic acids were performed employing
a continuous-flow approach using a simple flow reactor designed
in-house. Pd(PPh3)4 was used as catalyst, and arylboronic acids containing both electron-withdrawing and electron-donating groups were applied. The coupling process required 23 minutes of residence
time to be completed and generally good yields were obtained.
Subsequent arylation of 2-phenyl pyridine was carried out via a C-H activation strategy using substituted bromobenzene compounds
and a ruthenium(II) catalyst. To the best of our knowledge in this work we present for the first time the possibility of performing intermolecular C-H activation in a continuous-flow system.
Schlagworte:
heterocycles, cross coupling, flow chemistry, C-H activation, catalysis
"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.1055/s-0033-1339870
Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.