M. Koley, L. Wimmer, M. Schnürch, M.D. Mihovilovic:
"Pd(0) Catalyzed Cu(I) Thiophene-2-carboxylate Mediated Cross-Coupling of Heteroaromatic Thioethers and Boronic Acids - First Liebeskind-Srogl Reaction in Water";
Journal of Heterocyclic Chemistry,
The first example of a Liebeskind-Srogl cross-coupling reaction in water as sole reaction solvent is reported. 2-(Methylthio)pyridine and 2-(methylthio)benzothiazole were reacted in the presence of a Pd(0)catalyst and copper(I) thiophene-2-carboxylate with a series of arylboronic acids. These cross coupling reactions in water proceeded well with electron-rich boronic acids and gave comparable yields to literature examples using organic solvents. Electron-poor boronic acids gave somewhat lower yields in aqueous medium.
Erstellt aus der Publikationsdatenbank der Technischen Universitšt Wien.