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Vorträge und Posterpräsentationen (mit Tagungsband-Eintrag):

L. Wimmer, A. Schöffmann, Th. Schwarz, M. Schnürch, S. Khom, T. Erker, S. Hering, M.D. Mihovilovic:
"Synthesis Of Piperine Analogs As Gabaa Receptor Ligands";
Vortrag: 4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Hradec Kralove; 20.06.2014 - 22.06.2014; in: "Book of Abstracts", (2014), S. 30.



Kurzfassung englisch:
Black pepper is traditionally used in Asian folk medicine as antiepileptic, antianxiety, sedative, and
sleep inducing preparation. One of the ingredients of piper nigrum, its natural pungent alkaloid piperine,
was recently identified as a positive allosteric modulator of the major inhibitory neurotransmitter
receptors GABAA in the brain.1 Drugs enhancing chloride currents through GABAA receptors play an
important role in the treatment of general anxiety, panic disorders, sleep disturbances, and epilepsy.2,3
The present study is dedicated to the optimization of the piperine scaffold in terms of ligand potency
and receptor subtype selectivity. Compounds were tested for GABAA receptor activity using a twoelectrode
voltage clamp assay on Xenopus laevis oocytes.


Elektronische Version der Publikation:
http://publik.tuwien.ac.at/files/PubDat_230077.pdf


Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.