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L. Rycek, A Atanasov, V. Ticli, V. Dirsch, H. Stuppner, M. Schnürch, M.D. Mihovilovic:
"Towards Synthesis Of Notoincisol A And Notoicisol B, Natural Products With Potential Anti-Inflammatory Effect";
Poster: 4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Hradec Kralove; 20.06.2014 - 22.06.2014; in: "Book of Abstracts", (2014), S. 65.

Regulation of the inflammation is desirable as inflammation is directly linked with many serious
diseases, as for instance diabetes, cardiovascular diseases or cancer.1,2 Since the involvement of PPAR
receptor in the inflammatory process was revealed, this transcriptional factor has become a potential
target for treatment of the inflammation.3 Besides regulation of inflammation, activation of PPAR
receptor leads to the increased sensitivity towards insulin and cell proliferation.4 Therefore, PPAR is
nowadays used in clinic to treat type II diabetes by its full agonists represented by thiazolidinediones
(TZD). TZD however possess many serious side effects. Some studies suggest that using partial agonist
could lead to retaining of desired effects and elimination of the side effects due to the inducing
alternative receptor configuration.5 Notoincisol A and Notoincisol B are natural polyacetylenes recently
isolated by our partners from Notopterygium incisum. They showed to be partial agonists of PPAR
receptor. In this contribution, we will focus on the development of synthesis of both natural products,
confirming their stereochemistry and in latter stage synthesis of derivatives for SAR study.

http://publik.tuwien.ac.at/files/PubDat_230081.pdf