[Zurück]

A.A. Soliman, O. Alajrawy, F. Attabi, M. Shaaban, W. Linert:
"New formamidine ligands and their mixed ligand palladium(II) oxalate complexes: Synthesis, characterization, DFT calculations and in vitro cytotoxicity";
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 152 (2016), S. 358 - 369.

A series of new ternary palladium(II) complexes of the type [Pd(L1-4)ox].xH2O where L= formamidine ligands and ox=oxalate, were synthesized and characterized by elemental analyses, magnetic susceptibility, UV-Vis, infrared (IR) and mass spectroscopy and thermal analysis. The spectroscopic data indicated that the formamidine ligands act as bidentate N2 donors and the oxalate as O2 ligand. The complexes (1-4) are diamagnetic and the optimization of their structures indicated that the geometry is distorted square planer with O-Pd-O and N-Pd-N bond angles ranged 82.70°-83.87° and 88.21°-95.02°; respectively which is acceptable for the heteroleptic complexes. The dipole moment of the complexes (13.97-18.77 Debye) indicating that the complexes are more polarized than the ligands (1.93-4.96 Debye). The complexes are thermally stable as shown from their relatively higher overall activation energies (441- 688 kJmol-1). The ligands and the complexes are proved to have good cytotoxicity with IC50 (μM) in the range of (0.011-0.168) against MCF-7, (0.012-0.150) against HCT-116, (0.042-0.094) against PC-3 and (0.006-0.222) against HepG-2 cell lines, which open the field for further application as antitumor compounds.

ternary Pd(II) complexes, oxalate, formamidine, antitumor complexes.

http://dx.doi.org/10.1016/j.saa.2015.07.076