[Zurück]

M. Schnürch:
"Exploiting the C-H bond in metal-catalyzed C-C bond-forming reactions";
ARKIVOC, 2015 (2015), S. 212 - 243.

This account summarizes our work in the field of direct C-H bond functionalization. We have explored methods in the area of directing group assisted C(sp2)-H and C(sp3)-H activation and investigated arylation as well as deuteration reactions. In these transformations either ruthenium or palladium catalysts were applied. In case of C(sp2)-H activation, we developed a protocol for the synthesis of ortho arylated anilines and disclosed the first method for a direct arylation in a continuous flow reactor. Additionally, we applied a direct arylation in the synthesis of compounds which can accelerate cell differentiation. In the field of C(sp3)-H activation we
developed a protocol for the selective mono-arylation of piperidine and three different arylation protocols for acyclic amines employing either aryl chlorides, aryl bromides, aryl iodides, or arylboronic acid esters as the aryl donor.

C-H activation

http://dx.doi.org/10.3998/ark.5550190.p008.906

http://publik.tuwien.ac.at/files/PubDat_241511.pdf