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F. Paschke, C. Rabong, C. Schuster:
"Red light as a 12-oxo-leukotriene B 4 antagonist: an explanation for the efficacy of intensive red light in the therapy of peripheral inflammatory diseases";
Biomedical Engineering-Biomedizinische Technik, 59 (2014), 6; 487 - 493.

To explain the successful treatment of various
inflammatory diseases by using intensive red light,
a non-linear theory is presented for the interaction of
electric dipoles with light involving frequency doubling.
It is applied to analyze the influence of light on organic
molecules with permanent electric dipoles. The molecule
5-hydroxy-12-oxo-(5 S ,6 Z ,8 E ,10 E ,14 Z )-6,8,10,14-eicosatetraenoic
acid, 12-oxo-leukotriene B 4 (12-Oxo-LTB 4 , an
intermediate in the lipoxygenase-catalyzed path of arachidonic
acid metabolism), is suspected to play a major
role in the healing process, as, first, it plays a key role in
the metabolism of leukotriene B 4 (LTB 4 ), which in many
diseases acts as a source of inflammatory reactions; second,
its dipole resonance is located at a wavelength of 316
nm, which can be excited by a 632 nm source through frequency
doubling. From the structure of 12-Oxo-LTB 4 and
the knowledge of the partial charges of its 54 atoms, the
equivalent values for dipole charges and dipole moment
are derived. The power balance demonstrates that intensive
red light with a power density of 0.4 W/cm 2 transfers
sufficient energy to 12-Oxo-LTB 4 to render it biologically
inactive. Hence, by generating a reactive high-energy leukotriene
pathway intermediate, the law of mass action
steers the chemical equilibrium to interrupt the inflammatory
cascade.

To explain the successful treatment of various
inflammatory diseases by using intensive red light,
a non-linear theory is presented for the interaction of
electric dipoles with light involving frequency doubling.
It is applied to analyze the influence of light on organic
molecules with permanent electric dipoles. The molecule
5-hydroxy-12-oxo-(5 S ,6 Z ,8 E ,10 E ,14 Z )-6,8,10,14-eicosatetraenoic
acid, 12-oxo-leukotriene B 4 (12-Oxo-LTB 4 , an
intermediate in the lipoxygenase-catalyzed path of arachidonic
acid metabolism), is suspected to play a major
role in the healing process, as, first, it plays a key role in
the metabolism of leukotriene B 4 (LTB 4 ), which in many
diseases acts as a source of inflammatory reactions; second,
its dipole resonance is located at a wavelength of 316
nm, which can be excited by a 632 nm source through frequency
doubling. From the structure of 12-Oxo-LTB 4 and
the knowledge of the partial charges of its 54 atoms, the
equivalent values for dipole charges and dipole moment
are derived. The power balance demonstrates that intensive
red light with a power density of 0.4 W/cm 2 transfers
sufficient energy to 12-Oxo-LTB 4 to render it biologically
inactive. Hence, by generating a reactive high-energy leukotriene
pathway intermediate, the law of mass action
steers the chemical equilibrium to interrupt the inflammatory
cascade.

inflammation; intensive red light; leukotriene; non-linearity; phototherapy

http://dx.doi.org/10.1515/bmt-2014-0014