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A.A. Soliman, O. Alajrawy, F. Attabi, W. Linert:
"New dinuclear palladium(II) complexes with formamidine and bridged pyrophosphate ligands";
New Journal of Chemistry, 40 (2016), S. 8342 - 8354.

A series of new dinuclear palladium(II) complexes of the type [(PdL1-3)2(μPPi)].xH2O (1-3); where L= formamidine ligands and PPi=inorganic pyrophosphate, have been synthesized and characterized by, elemental analyses, magnetic susceptibility, UV-Vis., infrared (IR) and mass spectroscopy, thermal analysis and theoretical calculations. IR spectra confirmed that the formamidine act as bidentate N2 ligands. The complexes are diamagnetic and the optimized structures indicated that the geometry is distorted square planar with O-Pd-O and N-Pd-N bond angles ranged 90.85Åã-94.22Åã and 87.66Å-91.43Å; respectively, which is acceptable for the heteroleptic complexes. The electronic energies (a.u.) of the complexes (-1246 to -1916) indicate that the complexes are stable. The energies of the HOMOs (-0.204 to -0.283) and LUMOs (-0.057 to -0.097) orbitals of the complexes were negative which indicate that the complexes are stable. The dipole moment of the complexes (4.14-14.08 Debye) indicates that the complexes are polarized and they are thermally stable as shown from their relatively higher overall activation energies (537-1002 kJmol-1). Complexes were screened against PC-3 (prostate carcinoma cell line), HCT-116 (colon carcinoma cell line) and MCF-7 (breast carcinoma cell line). The IC50 of complexes were evaluated and the results show that [(PdL1)2(μPPi)].H2O (1) has the best IC50 value.

ternary Pd(II) complexes, pyrophosphate, formamidine, antitumor complexes.

http://dx.doi.org/10.1039/C6NJ01262K