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Zeitschriftenartikel:

M. Schön, D. Dreier, M. Schnürch, M.D. Mihovilovic:
"Library synthesis of cardiomyogenesis inducing compounds using an efficient two-​step-​one-​flow process";
Monatshefte für Chemie, 147 (2016), 3; S. 523 - 532.



Kurzfassung englisch:
Within this work we telescoped a batch laboratory scale synthesis towards a two-step-one-flow process to synthesize cardiomyogenesis inducing compounds (4,6-diaminopyrimidines) in continuous manner. Special attention was put on a quick and robust screening protocol and subsequent UHPLC analysis. Finally, the robustness of the method was proven by the multi-gram synthesis of VUT-MK142 using a laboratory scale continuous flow reactor, enabling to deliver enough material for extensive biological testing.

Schlagworte:
cardiomyogenesis inducing compounds, synthesis, continuous flow


"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.1007/s00706-015-1605-6


Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.