Publications in Scientific Journals:

M. Schön, D. Dreier, M. Schnürch, M.D. Mihovilovic:
"Library synthesis of cardiomyogenesis inducing compounds using an efficient two-​step-​one-​flow process";
Monatshefte für Chemie, 147 (2016), 3; 523 - 532.

English abstract:
Within this work we telescoped a batch laboratory scale synthesis towards a two-step-one-flow process to synthesize cardiomyogenesis inducing compounds (4,6-diaminopyrimidines) in continuous manner. Special attention was put on a quick and robust screening protocol and subsequent UHPLC analysis. Finally, the robustness of the method was proven by the multi-gram synthesis of VUT-MK142 using a laboratory scale continuous flow reactor, enabling to deliver enough material for extensive biological testing.

cardiomyogenesis inducing compounds, synthesis, continuous flow

"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)

Created from the Publication Database of the Vienna University of Technology.