Publications in Scientific Journals:
M. Schön, D. Dreier, M. Schnürch, M.D. Mihovilovic:
"Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process";
Monatshefte für Chemie,
147
(2016),
3;
523
- 532.
English abstract:
Within this work we telescoped a batch laboratory scale synthesis towards a two-step-one-flow process to synthesize cardiomyogenesis inducing compounds (4,6-diaminopyrimidines) in continuous manner. Special attention was put on a quick and robust screening protocol and subsequent UHPLC analysis. Finally, the robustness of the method was proven by the multi-gram synthesis of VUT-MK142 using a laboratory scale continuous flow reactor, enabling to deliver enough material for extensive biological testing.
Keywords:
cardiomyogenesis inducing compounds, synthesis, continuous flow
"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)
http://dx.doi.org/10.1007/s00706-015-1605-6
Created from the Publication Database of the Vienna University of Technology.