Zeitschriftenartikel:
N. Holmes, G. Akien, R. Savage, C. Stanetty, I. Baxendale, J. Blacker, B. Taylor, R. Woodward, R. Meadows, R. Bourne:
"Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors";
Reaction Chemistry & Engineering,
1
(2016),
1;
S. 96
- 100.
Kurzfassung deutsch:
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. The amidation of methyl nicotinate with aqueous MeNH2 was optimised using design of experiments and a self-optimisation algorithm approach to produce >93% yield.
Kurzfassung englisch:
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. The amidation of methyl nicotinate with aqueous MeNH2 was optimised using design of experiments and a self-optimisation algorithm approach to produce >93% yield.
"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.1039/c5re00083a
Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.