Publications in Scientific Journals:
M.F. Zia, A. Vasko, Z. Riedl, C. Hametner, G. Hajos, K. Mereiter, M.D. Mihovilovic:
"Biodihydroxylation of substituted quinolines and isoquinolines by recombinant whole-cell mediated biotransformations";
Tetrahedron,
72
(2016),
7348
- 7355.
English abstract:
The recombinant whole-cell mediated biooxygenation of various quinolines and isoquinolines was investigated employing three different dioxygenases of bacterial origin. Substrate screening focused on the biotransformation of cyano-substituted azaarenes, in particular. Efficiently accepted substrates were submitted to scale-up of the enzyme mediated reaction to preparative scale. The regio- and stereoselectivity of the obtained metabolites was established by NMR and X-ray diffraction after appropriate
derivatization.
Keywords:
Dioxygenases Biocatalysis Asymmetric synthesis Chemoenzymatic synthesis cis-Dihydrodiols
"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)
http://dx.doi.org/10.1016/j.tet.2016.06.077
Created from the Publication Database of the Vienna University of Technology.