Publications in Scientific Journals:
M.F. Zia, A. Vasko, Z. Riedl, C. Hametner, G. Hajos, K. Mereiter, M.D. Mihovilovic:
"Biodihydroxylation of substituted quinolines and isoquinolines by recombinant whole-cell mediated biotransformations";
The recombinant whole-cell mediated biooxygenation of various quinolines and isoquinolines was investigated employing three different dioxygenases of bacterial origin. Substrate screening focused on the biotransformation of cyano-substituted azaarenes, in particular. Efficiently accepted substrates were submitted to scale-up of the enzyme mediated reaction to preparative scale. The regio- and stereoselectivity of the obtained metabolites was established by NMR and X-ray diffraction after appropriate
Dioxygenases Biocatalysis Asymmetric synthesis Chemoenzymatic synthesis cis-Dihydrodiols
"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)
Created from the Publication Database of the Vienna University of Technology.