Zeitschriftenartikel:
M. Seifried, C. Knoll, G. Giester, Jan Welch, D. Müller, P. Weinberger:
"Aryl and Heteroaryl N1-Tetrazoles through Ligand-Free Suzuki-Reaction under Aerobic, Aqueous Conditions";
European Journal of Organic Chemistry,
17
(2017),
S. 2416
- 2424.
Kurzfassung englisch:
Substituted 1-biaryl-1H-tetrazoles are classically obtained from the corresponding 1-aminobiaryls, limiting the selection of substrates. The development and substrate scope of a green, ligand-free Suzuki protocol in aqueous media under ambient atmosphere, leading to 1-biaryl- and heteroaryl-substituted 1H-tetrazoles in very good to excellent yields is presented. The combination of PdCl2/NEt3/H2O/EtOH was found to combine high yields and high purity for all substrates investigated. Comparative experiments investigating the reaction rate
showed that the tetrazole does not act as a ligand for the palladium
catalyst.
Schlagworte:
tetrazole; Suzuki-coupling; Iron(II); Spin Crossover
"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.1002/ejoc.201700105
Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.