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Talks and Poster Presentations (with Proceedings-Entry):

S. Helfert, C. Dworak, E. Sevcsik, H. Peterlik, D. Ret, M. Sauer, R. Liska:
"Synthesis and Characterization of Polymer Linker Systems for Cell Studies";
Talk: Bypos Workshop 2017, Zemplínská Sírava, Slovakia; 2017-06-12 - 2017-06-16; in: "Bypos Workshop Book 2017", (2017), 29.



English abstract:
The generation and design of polymer brushes became very attractive in the field of biomedical applications. Their ability to control a number of important architectural features makes them a powerful tool in the creation of particular biointerfaces and applications in nanotechnologies on a variety of substrates.1 In this study, a strategy for a polymer linker system on SiO2 substrates was established, designed for the coupling to biomolecules. For the implementation of this polymer brush system, surface-induced reversible addition fragmentation chain transfer (RAFT) polymerization was chosen, delivering gentle polymerization conditions, absence of toxic catalysts, a variety of possible end-group modifications, uniform chain lengths and defined molecular weights. Poly-(N-acryloylmorpholine) and poly-(N-(3-methoxypropyl)acrylamide) were generated via RAFT polymerization with a MW of approximately 20 kDa. Their morphology and behavior in aqueous solutions was investigated via light scattering methods (SLS, DLS) and small angle X-ray scattering (SAXS) to predict their arrangement in a polymer brush system. The results of these measurements showed worm-like aggregation in aqueous environments. Further investigations were performed on end-group formation of these RAFT polymers and showed good results for radical induced end-group formation. Different approaches for the immobilization of a RAFT reagent on SiO2 surfaces were performed, using aminopropyl triethoxysilane (APTES), for grafting of polymers from the substrate and were analyzed via contact angle and ellipsometry.

Keywords:
polymer brushes, biomedical applications, nanotechnologies, polymer linker system on SiO2 substrates

Created from the Publication Database of the Vienna University of Technology.