[Zurück]

S. Baudis, E. Zerobin, M. Lunzer, Z. Tomasikova, X.H. Qin, M. Markovic, P. Gruber, J. Stampfl, A. Ovsianikov, R. Liska:
"Microfabricated Biocompatible Hydrogels";
Vortrag: VSS 2017 - Vienna young Scientists Symposium, Wien; 01.06.2017 - 02.06.2017; in: "VSS 2017", (2017), ISBN: 978-3-9504017-5-2; S. 11.

Lithography-based additive manufacturing technologies
("3D printing") enable the generation of arbitrary, highly complex
3D structures with very high resolution. This was one of the main
aspects, which attracted the interest of modern medicine. The vision
is to be able to fill defects in tissues or whole organs with tailormade,
patient-specific, biocompatible polymeric constructs, which
promote the regeneration of the tissue or the organ. Hydrogels are an
ideal basis for soft tissue regeneration as the mechanical properties
match with these of natural tissue and nutrients as well as
metabolites can migrate through the constructs easily. The concept
is to mimic the extracellular matrix (ECM) by modification of the natural components with
crosslinkable groups and to encapsulate cells by spatially resolved photopolymerization using the 2-
photon-technology.
Hyaluronan (HA) is a major component of the ECM. The introduction of double bonds to the back
bone of HA enables the production of photocrosslinked, biocompatible hydrogels. Functionalization
with (meth)acrylates is not unfavourable due to inherent cytotoxicity. The low cytotoxicity of vinyl
esters in combination with the superior photo-reactivity as thiol-ene system makes vinyl
esterfunctionalized HA (HAVE, Figure 1) an interesting candidate for biomaterial constructs for
tissue engineering.

Lithography-based additive manufacturing technologies, 3D printing, modern medicine