[Zurück]

S. Baudis, H. Bergmeister, K. Ehrmann, C. Dworak, C. Grasl, R. Liska:
"Enhancement of Mechanical Properties of Biogradable Thermoplastic Polyurethane Polymers for Their Application as Artificial Blood Vessel";
Poster: Danube Vltava Sava Polymer Meeting 2017, Wien; 05.09.2017 - 08.09.2017; in: "Danube Vltava Sava Polymer Meeting 2017", Book of Abstracts.com, (2017), ISBN: 978-3-9504017-6-9; S. PO-7.

Cardiovascular diseases are some of the most common causes of premature death
worldwide [1]. Usually surgical intervention is necessary for the treatment of the
disease, of which available options for action are limited: The use of autografts is
restricted which is mainly accounted for by accessibility. State of the art artificial grafts
lack long-term patency, especially with respect to small diameter vessels. Furthermore,
such substitutive materials are more likely to cause infection [2].
This project aims to overcome these deficiencies. Biodegradable thermoplastic
polyurethane linear block polymers of the first generation bearing an aliphatic
diisocyanate could be processed to small diameter vascular grafts via electrospinning
[3], [4]. Despite this novel material´s sufficient performance during in vivo studies,
ameliorations of mechanical properties are desirable. Current research focuses on the
substitution of applied diisocyanates with alicyclic options (Fig. 1). Enhanced
mechanical properties could be observed by DMTA, DSC and tensile testing in some
TPUs synthesized with alicyclic diisocyanates, giving comparable results to the nondegradable
benchmark Pellethane. The concept continues to stimulate native tissue
regeneration during biodegradation of the artificial graft and therefore avoids the
problem of non-patency.

small diameter vessels, Biodegradable thermoplastic polyurethane linear block polymers, substitution of applied diisocyanates with alicyclic options, to stimulate native tissue regeneration during biodegradation of the artificial graft