[Zurück]

S. Helfert, C. Dworak, E. Sevcsik, H. Peterlik, M. Sauer, D. Ret, R. Liska:
"Design and Synthesis of Tailor-made Nanostructured Polymer Biointerfaces";
Vortrag: Danube Vltava Sava Polymer Meeting 2017, Wien; 05.09.2017 - 08.09.2017; in: "Danube Vltava Sava Polymer Meeting 2017", Book of Abstracts.com, (2017), ISBN: 978-3-9504017-6-9; S. OP-11.

The design and synthesis of polymer brush systems became very attractive for applications in the biomedical field. Control of their architectural features and chemical environment offers possibilities for the creation of particular biointerfaces or applications in nanotechnologies on a variety of substrates [1].
In this study, we were interested in the establishment of such polymer brush biointerfaces by the usage of surface-induced reversible addition fragmentation chain transfer polymerization (RAFT) on various materials. Via covalent coupling of a RAFT-reagent to the surface, polymer brushes can be generated in a "grafting from" attempt, benefitting from the general advantages of RAFT polymerization (gentle polymerization conditions, absence of toxic catalysts, uniform chain lengths and defined molecular weights and a variety of possible end group modifications). Different acrylamides and vinyl esters were applied for the generation of their appropriate RAFT polymers and their morphology and behavior in aqueous environment were studied via light and X-ray scattering methods to predict their arrangement in a polymer brush system. Further studies were performed on proper end-group modification methods to provide a coupling to specific biomolecules. Investigations on the immobilization of the appropriate RAFT reagent to different substrate surfaces (SiO2, different polymers) were performed by usage of various coupling methods and characterization methods. To introduce spatial resolution of the polymerization and chain length of the particular polymer brushes on a substrates surface, experiments on one photon and two photon induced RAFT polymerization were performed.

synthesis of polymer brush systems, biomedical field, biointerfaces or applications in nanotechnologies on a variety of substrates, polymer brush biointerfaces by the usage of surface-induced reversible addition fragmentation chain transfer polymerizatio