[Zurück]

M. Rothbauer, H Zirath, P. Ertl:
"Recent advances in microfluidic technologies for cell-to-cell interaction studies";
Lab on a Chip, 18 (2018), S. 249 - 270.

Microfluidic cell cultures are ideally positioned to become the next generation in vitro diagnostic tools for biomedical research, where key biological processes
such as cell signalling and dynamic cell-to-cell interactions can be reliably analysed under reproducible physiological cell culture conditions. In the last decade
a large number of microfluidic cell analysis systems have been developed for a variety of applications including drug target optimization, drug screening and
toxicological testing. More recently, advanced in vitro microfluidic cell culture systems have emerged that are capable of recapitulating the complex threedimensional
architectures of tissues and organs, thus representing valid biological models to investigate mechanism and function of human tissue structures
as well as to study the onset and progression of diseases such as cancer. In this review, we present the most important developments in single-cell, 2D and 3D
microfluidic cell culture systems for studying cell-to-cell interactions published over the last 6 years, with focus on cancer research and immunotherapy,
vascular models and neuroscience. Additionally, the current technolgical development of microdevices with more advanced physiological cell
microenvironments interconnecting multiple organ models, so-called body-, human- and multi-organ-on-a-chip, are reviewed.

http://dx.doi.org/10.1039/C7LC00815E

http://publik.tuwien.ac.at/files/publik_262469.pdf