[Zurück]

D. Dreier, M. Holy, K. Jäntsch, H. Sitte, M.D. Mihovilovic:
"Synthesis of Photoswitchable Inhibitors for CNS Applications";
Poster: 7th Paul Ehrlich MedChem EuroPhD Network Symposium, Vienna; 25.08.2017 - 27.08.2017; in: "7th Paul Ehrlich MedChem EuroPhD Network Symposium", (2017), S. 41.

Recent advances in the field of photo pharmacology [1] enabled photo control
over a variety of proteins (e.g. ion channels). Photo switchable molecules can be switched
between two isomers by irradiation with light. Ideally, the biological activity of the two
isomers is largely different.
Within this contribution we investigate the feasibility to apply this concept to key
proteins of CNS networks. We present the synthesis of novel photo switchable analogs
based on well-studied ligands. Photo switchable small molecules might alter the
functionality of targeted proteins to be light dependent. These photo-sensitive proteins
would allow to study them in greater detail and thereby provide a deeper understanding
of their functionality.
Azobenzene and Hemithioindigo [2] based photo switches (Figure 1) were
utilized as two potential substance classes to achieve our goals. These two compound
classes exhibit a wide range of thermal half-life times and different activation
wavelengths. In addition, we report on preliminary biological data obtained from cell
based assays.

http://publik.tuwien.ac.at/files/publik_264673.pdf