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D. Cintulova, L. Wimmer, H. Sitte, M.D. Mihovilovic:
"Synthesis and biological evaluation of Mephedrone metabolites";
Vortrag: 7th Merting of The Paul Ehrlich MedChem-Euro PhD Network, Wien; 25.08.2017 - 27.08.2017.

The endogenous monoamines dopamine, serotonin and norepinephrine are
essential neurotransmitters in the mammalian system. They have been the focus of
considerable research because their interaction at monoamine transporters has profound
effects upon many pharmacological outcomes1. One diverse class of chemical compounds
- the amphetamines, acts as inhibitors of monoamine transporter system and thus elicits
strong psychostimulant effect which renders them liable for recreational abuse2.
One frequently occurring recreational drug of this group is mephedrone - a
derivative of naturally occurring alkaloids - cathinones. Mephedrone has been linked to
a number of fatalities and seizure incidents across Europe. Despite its short time in blood
plasma this compound has a long lasting effect in humans3.
Within this contribution we present the enantioselective synthesis of Phase I
mephedrone metabolites to better understand the mode of action of mephedrone itself and
to investigate the activity of single enantiomers of its metabolites.

mephedrone, metabolites, derivatives. monoamine transporters