Talks and Poster Presentations (with Proceedings-Entry):
T. Weber, S. Wassertheurer, A. Schmidt-Trucksäss, E. - R. Sala, P. Jankowski, M.L. Muiesan, C. Giannattasio, I. Wilkinson, J Kellermair, B. Hametner, J. M. Pascual, R. Zweiker, D. Czarnecka, A. Paini, M. Salvetti, A. Maloberti, P. Fitscha, K. Mortensen, E. Wagner, C. McEniery, C. Ablasser:
"Circadian variations in the cardiovascular system";
Talk: Artery Conference 2017,
- 2017-10-14; in: "Artery Conference 2017",
J. Cockroft, S. Laurent, C. Vlachopoulos (ed.);
Teddington, Middlessex, U.K.
Background: Comprehensive information on 24-hour profiles of pulsatile as well as steady-state hemodynamics in humans is not available yet.
Methods: In 693 healthy individuals (352 men) fee from antihypertensive drugs, we performed 24-hour blood pressure (BP) monitoring with a validated oscillometric brachial cuff (mobilograph, i.e.m. Stolberg, Germany). Brachial waveforms were acquired and processed with ARCSolver algorithms to derive information on central pressures, wave reflections, stroke volume and systemic vascular resistance. Nighttime/daytime difference(ND/) was defined as nighttime (01.00-06.00) minus daytime (09.00-21.00) values / daytime values. Patients were categorized as young (Y:15-40 years; n=187), middle-aged (M. 41-70 years; n=446), and old (O: 71-94 years; n=60).
Results: Averaged 24-hour brachial BP was 123/78 (Y), 127/82 (M), and 126 / 74 (O) mm HG. N/D for brachial SBP was 13 % (Y), - 12% (M), and - 5 %(O). N/D for heart rate was - 20% (Y), - 17 % (M), and - 15 % (O). N/D for central SBP was less pronounced: - 4% (Y), - 6% (M), and -0% (O).
Brachial pulse pressur (PP) dislplayed small circadian variations, whereas central PP was higher at nighttime: N/D was 25% (Y), 14% (M), and 17 % (O). Consequently, PP amplification was higher at daytime (N/D was - 21% (Y), - 16 % (M), and -12 % (O), and was related to heart rate, age, and gender.
Measures of ware reflections were higher at nighttime, with N/D related to age, geart rate, mean pressure, systemic vascular resistance and stroke volume.
Conclusion: The circadian profiles we provice may serve as reference for cardiovascular diseases and drug studies.
"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)
Created from the Publication Database of the Vienna University of Technology.