Talks and Poster Presentations (with Proceedings-Entry):
C. Mayer, B. Hametner, K Whitelegg, T. Weber, S. Wassertheurer:
"Sex-specific pulse wave velocity cut-offs improve survival analysis in patients with suspected coronary artery disease";
Talk: Artery Conference 2017,
- 2017-10-14; in: "Artery Conference 2017",
J. Cockroft, S. Laurent, C. Vlachopoulos (ed.);
Objectives: there is evidence for sex and age influences on pluse wave velocity (PWV). Guidelines suggest a sex-independet cut-off for PWV. It is not obvious that an age- and blood-pressure-independent cut-off is suitable in different populations [1,2].
Thus, the aim is to investigate the suitability of sex-independent cut-offs for risk prediction in a high-risk cohort.
Methods: PWV was measured invasively (iv.PWV; catheter pullback) and non-ivaseively (non- invPWV; ARCSolver PWV) for patients with suspected CAD at the hospital in Wels- Grieskirchen (Austria). Patients were grouped in for subgroups based on sex and PWV cut-offs (guidlines and sex-specific ones). A combination of myocardial infarction, death, stroke and cardiovascular revascularization served as primary endpoint. Kaplan-Meier curves, logrank test and hazard-ratios were used for survival analysis and receiver-oprating-characteristics (ROC) to determine sex-specific cut-offs.
results: 604 male (61 (11 SD) years) and 324 female (65 (11 SD) years) with a median follow-up of 1576 days and 215 events were included. Logrank test revealed significant differences beween Kaplan-Meier curves (p<0.001), but dichotomized PWV remained just discrimminative in women, but not men, for invasive and non- invasive recordings. ROC analysis revealed sex-specific cut-offs of 8.5 m/s (men) of 9.6 m/s (women) for invasive and 8.9 m/s (men) or 10.0 m/s (women) for non- ivasive recordings. When using these cut-offs, PWV turned out to be discriminative in both sexes (Table).
"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)
Created from the Publication Database of the Vienna University of Technology.