R El-Zahry, B. Lendl:
"Structure elucidation and degradation kinetic study of Ofloxacin using surface enhanced Raman spectroscopy";
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 193 (2018), S. 63 - 70.

Kurzfassung englisch:
OFX, (±) 9-fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-
acid (Fig. 1). OFX is a fluorinated quinolone antibacterial agent used in
the treatment of a wide range of infections. It is a member of the third
generation of quinolone synthetic antibiotics with a broad spectrum of
activity against Gram-positive and Gram-negative bacteria through inhibition
of their DNA gyrase [1,2]. The current analytical procedures
used for quantitative determination of OFX are UV/VIS spectrophotometry
[3-5] in pharmaceuticals, chemiluminescence methods [6,7],
spectrofluorimetric methods [8-11], HPLC with UV and fluorescence
detection in more complicated samples [12-15] although electrochemical
analysis methods are used for this purpose [16-19].
Flow injectionmethods are described in the quantitative determination
of OFL using chemiluminescence detection [20,21]. Owing to their
pharmacologically importance, the attention to the stability of
fluoroquinolones has been concerned by many scientists. According to
ICH, the stability testing has been established.
After careful survey in the literature review of the analysis of OFX,
there is limited number of research articles discussing the stability indicating
study of OFX using HPLC methods.

"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)

Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.